Serotonin: A new super effective functional monomer for molecular imprinting. The case of TNF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.svg"><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math> detection in real matrix by Surface Plasmon Resonance

Battaglia, Federica; Torrini, Francesca; Palladino, Pasquale; Scarano, Simona; Minunni, Maria

doi:10.1016/j.bios.2023.115713

Cited by 6 publications

(1 citation statement)

References 58 publications

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“…Analytes, when removed via physical or chemical methods, leave behind a memorial site in the matrix of polymer specific to a particular analyte. MIPs have some specific advantages such as low cost of preparation, high affinity to the template, robustness, and long-term stability. − Since a few decades, neurotransmitters, such as dopamine (DA), serotonin, norepinephrine, etc., have made these biopolymers accessible for the synthesis of molecularly imprinted biopolymers (MIBPs). − Our group has previously worked on the fabrication of a polydopamine-MIP (PDA-MIP)-based electrochemical sensor for the detection of 4-EPS . However, the incorporation of nanomaterials, in this case MoS 2 nanosheets, in MIP-based electrochemical sensors showed enhanced sensitivity, a broader range of detection, and improved stability of the fabricated electrodes.…”

Section: Introductionmentioning

confidence: 99%

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS₂ Nanosheet-Modified Molecularly Imprinted Biopolymer

Archana,

Kumar,

Solanki

2024

ACS Appl. Bio Mater.

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One of the gut-derived uremic toxins 4-ethylphenyl sulfate (4-EPS) exhibits significantly elevated plasma levels in chronic kidney diseases and autism, and its early quantification in bodily fluids is important. Therefore, the development of rapid and sensitive technologies for 4-EPS detection is of significant importance for clinical diagnosis. In the current work, the synthesis of a molecularly imprinted biopolymer (MIBP) carrying 4-EPS specific cavities only using the biopolymer polydopamine (PDA) and molybdenum disulfide (MoS 2 ) nanosheets has been reported. The fabricated electrode was prepared using screen-printed carbon electrodes on a polyvinyl chloride substrate. The synthesized material was characterized using several techniques, and electrochemical studies were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The DPV technique for the electrochemical sensing of 4-EPS using the fabricated sensor (PDA@MoS 2 -MIBP) determined a sensitivity of 0.012 μA/ng mL/cm 2 and a limit of detection of 30 ng/mL in a broad linear range of 1−2200 ng/mL. Also, the interferent study was performed to evaluate the selectivity of the fabricated sensor along with the control and stability study. Moreover, the performance of the sensor was evaluated in the spiked urine sample, and a comparison was made with the data obtained by ultraperformance liquid chromatography−tandem mass spectroscopy.

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Section: Introductionmentioning

confidence: 99%

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS₂ Nanosheet-Modified Molecularly Imprinted Biopolymer

Archana,

Kumar,

Solanki

2024

ACS Appl. Bio Mater.

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Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Tavakoli,

Hu,

Tipper

et al. 2024

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In recent years, the substantial increase in total joint replacements for treating degenerative joint disease has heightened concerns regarding implant loosening and failure. This is especially critical as more young patients are undergoing both initial and subsequent joint replacement procedures. These complications often necessitate additional revision surgeries. Unfortunately, current clinical practices lack effective methods for the early detection of implant failure, and there is a noticeable absence of strategies utilizing molecular markers to identify post‐surgery implant issues. This article critically assesses the potential of aggregation‐induced emission (AIE) biomarkers in detecting molecular markers relevant to implant failure. It begins by outlining the pathogenesis of implant loosening and identifying pertinent molecular markers. The study then delves into how AIE luminogens (AIEgens) can play a crucial role in detecting processes such as osteogenesis and osteoclastogenesis. Notably, it discusses the utilization of AIEgens in detecting key molecular markers, including TNF‐α, osteocalcin, and urinary N‐terminal telopeptide. The prospect of AIE biomarkers for the early detection of bone loss and implant failure presents a promising avenue for enhancing our understanding of skeletal health and improving clinical outcomes through timely intervention and personalized treatment approaches. Ongoing research and development in this area are crucial for translating AIE‐based technologies into practical tools for optimizing bone health management.

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Advances in the selection of functional monomers for molecularly imprinted polymers: A review

Niu,

Du,

et al. 2024

J of Separation Science

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Molecularly imprinted polymers, a type of special polymer materials, are widely used in biosensing and other fields due to their ability to specifically recognize target molecules, often called “artificial receptors.”. Nowadays, researchers are constantly exploring new design and synthesis methods for molecularly imprinted materials to improve the selectivity and sensitivity of molecularly imprinted materials. Among them, the selection of functional monomers has attracted great attention. This review comprehensively analyzes and discusses the selection methods of functional monomers. The most commonly used functional monomers among different types of templates are screened based on the structural properties of the template molecules, including the selection of functional monomers among ion‐imprinted polymers, protein‐imprinted polymers, and bacterial imprinted polymers. The rich binding sites and functional group types of multifunctional monomers are also highlighted to advance the development of molecular imprinting technology. The article further explores the current challenges and prospects in the selection of functional monomers and emphasizes multiplex experiments and computer simulations as important directions for future research. This review provides comprehensive information and constructive guidelines for researchers in selecting functional monomers in areas such as analytical chemistry and biosensors.

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Serotonin: A new super effective functional monomer for molecular imprinting. The case of TNF-α detection in real matrix by Surface Plasmon Resonance

Cited by 6 publications

References 58 publications

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS₂ Nanosheet-Modified Molecularly Imprinted Biopolymer

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS₂ Nanosheet-Modified Molecularly Imprinted Biopolymer

Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Advances in the selection of functional monomers for molecularly imprinted polymers: A review

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Serotonin: A new super effective functional monomer for molecular imprinting. The case of TNF-α detection in real matrix by Surface Plasmon Resonance

Cited by 6 publications

References 58 publications

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer

Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Advances in the selection of functional monomers for molecularly imprinted polymers: A review

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Product

Resources

About

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS₂ Nanosheet-Modified Molecularly Imprinted Biopolymer

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS₂ Nanosheet-Modified Molecularly Imprinted Biopolymer