Serotonin and systemic sclerosis. An emerging player in pathogenesis

Sagonas, Ioannis; Daoussis, Dimitrios

doi:10.1016/j.jbspin.2021.105309

Cited by 7 publications

(3 citation statements)

References 81 publications

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“…It is widely accepted that TGFβ promotes fibrosis in the skin and the lung by inducing fibroblast proliferation, extracellular matrix degradation and the upregulation of profibrotic genes such as those encoding collagen A1, collagen A2 and fibrillin, which have demonstrated roles in the pathogenesis of SLE and systemic sclerosis 158 , 159 . Other platelet-derived molecules, such as thymic stromal lymphopoietin and serotonin, are associated with the progression of skin fibrosis in systemic sclerosis 112 , 160 . Platelet-derived β-thromboglobulin and CXCL4 have been associated with fibrosis in experimental models, and they are found at increased levels in the lungs of patients with systemic sclerosis who have lung fibrosis 161 .…”

Section: Role Of Platelets In End Organ Damagementioning

confidence: 99%

The role of platelets in immune-mediated inflammatory diseases

et al. 2023

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Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death. Platelets have long been known for their role in primary haemostasis, but they are now also considered to be components of the immune system and to have a central role in the pathogenesis of IMIDs. In patients with IMIDs, platelets are activated by disease-specific factors, and their activation often reflects disease activity. Here we summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of IMIDs. Activated platelets produce soluble factors and directly interact with immune cells, thereby promoting an inflammatory phenotype. Furthermore, platelets participate in tissue injury and promote abnormal tissue healing, leading to fibrosis. Targeting platelet activation and targeting the interaction of platelets with the immune system are novel and promising therapeutic strategies in IMIDs.

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Section: Role Of Platelets In End Organ Damagementioning

confidence: 99%

The role of platelets in immune-mediated inflammatory diseases

et al. 2023

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“…Serotonin is formed during malolactic and alcoholic fermentation by the action of yeast and lactic acid bacteria, and it is derived from the decarboxylation of L-tryptophan [66]. According to Sagonas et al [67], serotonin is a crucial mediator in fibrosis and vasculopathy, helping in diseases like systemic sclerosis.…”

Section: Melatonin and Serotoninmentioning

confidence: 99%

Beyond the Bottle: Exploring Health-Promoting Compounds in Wine and Wine-Related Products—Extraction, Detection, Quantification, Aroma Properties, and Terroir Effects

Marques,

Dinis,

Santos

et al. 2023

Foods

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Health-promoting compounds in wine and wine-related products are important due to their potential benefits to human health. Through an extensive literature review, this study explores the presence of these compounds in wine and wine-related products, examining their relationship with terroir and their impact on the aromatic and flavor properties that are perceived orally: sunlight exposure, rainfall patterns, and soil composition impact grapevines’ synthesis and accumulation of health-promoting compounds. Enzymes, pH, and the oral microbiome are crucial in sensory evaluation and perception of health promotion. Moreover, their analysis of health-promoting compounds in wine and wine-related products relies on considerations such as the specific target compound, selectivity, sensitivity, and the complexity of the matrix.

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“…The role of serotonin in SSc, mainly as a mediator of fibrosis and vasculopathy, has been recently reviewed [17].…”

Section: Introductionmentioning

confidence: 99%

Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women

Turska-Kozłowska,

Pedraz-Petrozzi,

Paluszkiewicz

et al. 2024

IJMS

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Systemic sclerosis (SSc), a predominantly female-affected systemic autoimmune disease, requires tailored treatment strategies contingent on organ involvement and symptom severity. Given SSc’s inflammatory nature, the involvement of the kynurenine pathway (KP) in its pathophysiology is underexplored. Our study aimed to investigate sex-related differences in KP activation among SSc patients and assess the impact of angiotensin-converting enzyme (ACE) inhibitors and estimated glomerular filtration rate (eGFR) on KP metabolite concentrations. We enrolled 48 SSc patients and 53 healthy controls, quantifying KP metabolites (tryptophan (TRP), kynurenine (KYN), and kynurenic acid (KYNA)) in serum via high-performance liquid chromatography. Separate multivariate analyses of covariance (MANCOVAs) for women and men were performed to ascertain mean differences between patients and healthy controls while correcting for age. For our secondary objective, we conducted a MANCOVA to explore disparities in ACE inhibitor users and non-users among patients, with BMI correction. Our findings revealed decreased TRP concentrations but increased KYNA/TRP ratio and KYN/TRP ratio in both male and female SSc patients compared to their respective controls. Unlike women, SSc males exhibited higher KYN concentrations and decreased KYNA/KYN ratio relative to their controls. Additionally, SSc patients using ACE inhibitors had higher serum KYNA levels than non-users. Notably, we established a significant correlation between eGFR and KYNA in SSc patients. These results indicate differential KP activation in male and female SSc patients, with males demonstrating heightened KP activation. While ACE inhibitors may influence the KP in SSc patients, further research is necessary to comprehensively understand their impact on symptoms and prognosis in the context of these KP alterations.

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Serotonin and systemic sclerosis. An emerging player in pathogenesis

Cited by 7 publications

References 81 publications

The role of platelets in immune-mediated inflammatory diseases

The role of platelets in immune-mediated inflammatory diseases

Beyond the Bottle: Exploring Health-Promoting Compounds in Wine and Wine-Related Products—Extraction, Detection, Quantification, Aroma Properties, and Terroir Effects

Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women

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