Serotonin Antagonist Increases Longevity in Mice With Hereditary Muscular Dystrophy.

Abstract

5792,3,4 were observed only when large momts of radioactive C057 BI2 were added. Since the p k s consist of mixtures of proteins, identification of the specific proteins binding Co5' B12 cannot be delineated. Summary. A method was described for the separation of vit B12 binders in normal serum on a 15 X 4 cm DEAEcellulose column by stepwise elution with 0.005 M pH 8.0, 0.0175 M pH 6.3, 0.04 M pH 5.9, 0.1 M pH 5.8 and 0.4 M pH 5.2 sodium phosphate buffers.Two radioactive peaks appeared when 300 ppg C057 B12 per ml of serum had been added in vitro. With the addition of 2,000 ppg/ml of C057 BI2 to the serum, 5 radioactive peaks appeared.The occurrence of hereditary muscular dystrophy in an inbred strain of mice was first reported by Michelson et aZ( 1 ) , and in-