Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, <i>Procambarus clarkii.</i>

Fossat, Pascal; Bacqué-Cazenave, Julien; Deurwaerdère, Philippe De; Cattaert, Daniel; Delbecque, Jean‐Paul

doi:10.1242/jeb.120550

Cited by 63 publications

(73 citation statements)

References 43 publications

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“…Similarly with our observations after physical stress, taking into account that this specific anxiolytic drug has no effect on isolated or unstressed crayfish7, the suppression of social ALB in losers confirms that it is homologous to human anxiety. Also consistent with our previous observations with physical stress16, social ALB was clearly correlated with the intensity of stress that was suffered by the losers, i.e., stress caused by the aggressive acts of the winners. Figure 3 shows that the ALB intensity in the losers was correlated with the approaches and attacks of the winners throughout the entire pairing period (Fig.…”

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confidence: 91%

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Social harassment induces anxiety-like behaviour in crayfish

Bacqué-Cazenave

Cattaert

Delbecque

et al. 2017

Sci Rep

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Social interactions leading to dominance hierarchies often elicit psychological disorders in mammals including harassment and anxiety. Here, we demonstrate that this sequence also occurs in an invertebrate, the crayfish Procambarus clarkii. When placed in the restricted space of an aquarium, crayfish dyads generally fight until one of the opponents suddenly escapes, thereafter clearly expressing a submissive behaviour. Nevertheless, the winner frequently keeps on displaying excessive aggressive acts, having deleterious consequences in losers and interpreted as harassment behaviour. We indeed observed that, contrary to winners, losers expressed anxiety-like behaviour (ALB) in correlation with the stress intensity they suffered during the harassment period mainly. Injections of an anxiolytic abolished ALB, confirming its homology with anxiety. A serotonin (5-HT) antagonist had the same effect, suggesting a role for 5-HT, whose brain concentrations increased much more in losers than in winners. Our findings suggest that the bases of harassment and of its anxiogenic consequences have emerged very early during evolution, and emphasize crayfish as an unexpected but potentially fruitful model for the study of these social disorders.

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confidence: 91%

“…We estimated the ALB level of the winning and losing male crayfish after a 20-min pairing by measuring their light avoidance behaviour in a dark/light plus maze716. The results in Fig.…”

mentioning

confidence: 99%

Social harassment induces anxiety-like behaviour in crayfish

Bacqué-Cazenave

Cattaert

Delbecque

et al. 2017

Sci Rep

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“…entering a brightly lit arm of a plus maze [16,20]. Serotonin also appears to be involved in the activation of the CHH stress response and subsequent release of glucose and increased lactate.…”

Section: Discussionmentioning

confidence: 99%

Electric shock causes physiological stress responses in shore crabs, consistent with prediction of pain

Elwood

Adams

2015

Biol. Lett.

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Animal pain is defined by a series of expectations or criteria, one of which is that there should be a physiological stress response associated with noxious stimuli. While crustacean stress responses have been demonstrated they are typically preceded by escape behaviour and thus the physiological change might be attributed to the behaviour rather than a pain experience. We found higher levels of stress as measured by lactate in shore crabs exposed to brief electric shock than non-shocked controls. However, shocked crabs showed more vigorous behaviour than controls. We then matched crabs with the same level of behaviour and still found that shocked crabs had stronger stress response compared with controls. The finding of the stress response, coupled with previous findings of long-term motivational change and avoidance learning, fulfils the criteria expected of a pain experience.

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“…When serotonin reception is blocked, individuals fail to respond to predator odours (Il-Han et al, 2010). Similarly, increased serotonin in crayfish (Procambarus clarkii) and sea hares (Aplysia californica) has been found to lead to increased responses and sensitivity to acute stressors such as an electrical shock (Fossat et al, 2015;Marinesco and Carew, 2002).…”

Section: Endocrine Responsesmentioning

confidence: 99%

Mechanisms underlying the control of responses to predator odours in aquatic prey

Mitchell

Bairos‐Novak

Ferrari

2017

Journal of Experimental Biology

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In aquatic systems, chemical cues are a major source of information through which animals are able to assess the current state of their environment to gain information about local predation risk. Prey use chemicals released by predators (including cues from a predator's diet) and other prey (such as alarm cues and disturbance cues) to mediate a range of behavioural, morphological and life-history antipredator defences. Despite the wealth of knowledge on the ecology of antipredator defences, we know surprisingly little about the physiological mechanisms that control the expression of these defensive traits. Here, we summarise the current literature on the mechanisms known to specifically mediate responses to predator odours, including dietary cues. Interestingly, these studies suggest that independent pathways may control predator-specific responses, highlighting the need for greater focus on predator-derived cues when looking at the mechanistic control of responses. Thus, we urge researchers to tease apart the effects of predator-specific cues (i.e. chemicals representing a predator's identity) from those of dietmediated cues (i.e. chemicals released from a predator's diet), which are known to mediate different ecological endpoints. Finally, we suggest some key areas of research that would greatly benefit from a more mechanistic approach.

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Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

Cited by 63 publications

References 43 publications

Social harassment induces anxiety-like behaviour in crayfish

Social harassment induces anxiety-like behaviour in crayfish

Electric shock causes physiological stress responses in shore crabs, consistent with prediction of pain

Mechanisms underlying the control of responses to predator odours in aquatic prey

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