Serotonin immunoreactivity in the autonomic intrapulmonary ganglia of the fetal sheep

Balaguer, L.; Romano, Jacinta; Ruiz-Pesini, Pedro

doi:10.1016/0304-3940(91)90557-a

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…Therefore, our present study is the first to document precisely the developmental course of pulmonary endocrine cells in sheep lungs by the immunohistochemical quantitative analysis. Recent immunohistochemical studies of various kind of mammals showed that the pulmonary endocrine cells have various kinds of neuroendocrine markers such as serotonin [1,9,11,12,18,21,28], bombesin [1,6,12,23,24,28], gastrin-releasing peptide [1], cholecystokinin [27], calcitonin [1,12,23], calcitonin gene related peptide [1,28], leuenkephalin [1,12], NSE [1,8,18] and chromogranin [1].…”

Section: Resultsmentioning

confidence: 99%

“…These immunohistochemical studies revealed that serotonin, cholecystokinin and neuron-specific enolase (NSE) immunoreactivity were identified in both solitary endocrine cells and endocrine cell clusters (i.e., neuroepithelial bodies, NEBs) of the sheep lung. Balaguer et al [8,9] also showed that the earliest identifiable endocrine cells appeared at 5 weeks of gestation, which is close to the term of the embryonic period. They also reported that endocrine cells in the sheep airways were more numerous in distal conducting airways and fetal stages.…”

mentioning

confidence: 78%

“…Pulmonary endocrine cells are widely distributed throughout the airway mucosa and are thought to play an important role in lung development and maturation from intrauterine life to the postnatal period [1,6,8,9,11,16,18,27]. The principal role of pulmonary endocrine cells during intrauterine life is considered to involve the maintenance of active pulmonary vasoconstriction in the relatively hypoxic lung, as well as the rapid vasodilation upon the aeration of the lung at birth [12].…”

mentioning

confidence: 99%

“…Since then, several reports have been published on the structure and distribution of pulmonary endocrine cells of sheep [8][9][10]28]. These immunohistochemical studies revealed that serotonin, cholecystokinin and neuron-specific enolase (NSE) immunoreactivity were identified in both solitary endocrine cells and endocrine cell clusters (i.e., neuroepithelial bodies, NEBs) of the sheep lung.…”

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confidence: 99%

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Quantitative Study of Pulmonary Endocrine Cells in Fetal, Postnatal and Adult Sheep

Asabe

Jennings²,

Harrison³

et al. 2004

J. Vet. Med. Sci.

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ABSTRACT. Using light microscopic immunohistochemistry, neuron-specific enolase (NSE)-positive endocrine cells were quantitatively analyzed in the sheep lung during different stages of development from the canalicular stages to adulthood. In all stages, NSE-positive endocrine cells were usually located in the bronchi and bronchioles as solitary cells, although a few NSE-positive cell clusters, the socalled neuroepithelial bodies, were found in some places. The number of NSE-positive endocrine cells decreased with advanced stages of gestation. In the late alveolar stage, the number of NSE-positive endocrine cells reached its bottom during the fetal period. There was a gradual upturn after birth. The overall pattern of growth and differentiation of the endocrine cells is most likely species-related and depends on the state of airway development; the number of the endocrine cells of almost all animals, excluding the sheep, in relation to the size of the lung reaches a peak in the late fetal and early neonatal periods and decreases shortly thereafter. NSE-posit ive endocrine cells were also predominantly located in the large airways during the early stage of development (canalicular stage), and were found more frequently in the small peripheral airways towards the term. These results show the number of NSE-positive endocrine cells in t he sheep to be different from that seen in other species. KEY WORDS: endocrine cell, lung, sheep.

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Section: Resultsmentioning

confidence: 99%

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confidence: 78%

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confidence: 99%

mentioning

confidence: 99%

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Quantitative Study of Pulmonary Endocrine Cells in Fetal, Postnatal and Adult Sheep

Asabe

Jennings²,

Harrison³

et al. 2004

J. Vet. Med. Sci.

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“…Most peribronchial ganglia are located between large bronchi and the accompanying pulmonary arteries, and have close associations with bronchial capillaries [88,100]. It is clear that paraganglionic cells in the lung can contain dopamine [102] or serotonin [105], although the presence of serotonin immunoreactivity may be dependent upon developmental stage [105]. At the electron-microscopic level, synaptic contact can be observed between multiple types of efferent terminals, including cholinergic type synapses [102], and granule-containing cells [100].…”

Section: Intrapulmonary Peribronchial Ganglia ('Microparaganglia')mentioning

confidence: 99%

Pathways Underlying Afferent Signaling of Bronchopulmonary Immune Activation to the Central Nervous System

Hale

Rook

Lowry

2012

Chemical Immunology and Allergy

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Bronchopulmonary inflammation, such as that associated with asthma, activates afferent neural pathways. We recently demonstrated that localized inflammation in the lungs, induced by intratracheal administration of ovalbumin in ovalbumin-preimmunized mice (an animal model of asthma) results in activation of the dorsolateral part of the nucleus of the solitary tract, a major target of vagal afferent fibers innervating the lungs and airways. Activation of the nucleus of the solitary tract was evident in the absence of activation of the area postrema, a circumventricular organ, consistent with the hypothesis that localized inflammation in the bronchopulmonary system can signal to the central nervous system via specific neural pathways, in the absence of circulating proinflammatory mediators. The pattern of brain activation in ovalbumin-challenged mice differs from the pattern of activation in mice challenged with heat-killed Mycobacterium vaccae, suggesting that qualitative aspects of bronchopulmonary inflammation determine the overall pattern of brain activation. The mechanisms through which localized bronchopulmonary inflammation signals to the central nervous system is poorly understood, but appears to involve both vagal and spinal afferent pathways. In this chapter, we review our current understanding of the anatomical pathways through which localized inflammation in the bronchopulmonary system influences central nervous system function.

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Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction

Raeburn¹,

Giembycz²

1995

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Serotonin immunoreactivity in the autonomic intrapulmonary ganglia of the fetal sheep

Cited by 7 publications

References 11 publications

Quantitative Study of Pulmonary Endocrine Cells in Fetal, Postnatal and Adult Sheep

Quantitative Study of Pulmonary Endocrine Cells in Fetal, Postnatal and Adult Sheep

Pathways Underlying Afferent Signaling of Bronchopulmonary Immune Activation to the Central Nervous System

Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction

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