Serotonin in protozoa

Janakidevi, K.; Dewey, Virginia C.; Kidder, George W.

doi:10.1016/0003-9861(66)90259-1

Cited by 68 publications

(26 citation statements)

References 5 publications

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“…Later, serotonin was also discovered in both Crithidia and Tetrahymena by Janakidevi et al (4). Furthermore, Blum et al (5) suggested that clofibrate, a hypolipidemic agent, inhibited glyconeogenesis or activated glycogenolysis in Tetrahymena.…”

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confidence: 99%

Effect of Compounds Affecting the Adrenergic Mechanism on Cell Growth and Division of Tetrahymena Pyriformis W

Iwata

Kariya

Fujimoto

1969

Japanese Journal of Pharmacology

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Janakidevi et al. (1) showed that the ciliated protozoan, Tetrahymena pyriformis, could biosynthesize both of adrenaline and noradrenaline, while the flagellated protozoan, Crithidia fasciculata, biosynthesized only adrenaline. Accordingly, Blum et al. (2) studied the effect of reserpine on the protozoan and found that it inhibited growth and decreased the catecholamine content. Furthermore, Blum (3) investigated the effects of drugs which interacted with the action of catecholamine in mammals, on the glycogen content and growth of Tetrahymena, and suggested a relationship between glycogen synthesis and the control system for adrenergic metabolism in Tetrahymena.Later, serotonin was also discovered in both Crithidia and Tetrahymena by Janakidevi et al. (4). Furthermore, Blum et al. (5) suggested that clofibrate, a hypolipidemic agent, inhibited glyconeogenesis or activated glycogenolysis in Tetrahymena. And recently, Blum (6) reported that adrenergic control system of Tetrahymena influenced a peroxisomal enzyme which acted the first step of glyconeogenesis from acetyl-CoA.In an earlier publication from our laboratory (7), we recognized that the growth of Tetrahymena was promoted by dibenamine or ergotamine. The present paper is on the effect of the compounds used in previous experiments, on growth during 72 hours, and on the cell growth and division in one life cycle of the protozoan. MATERIALS AND METHODS Culture method of Tetrahymena for 72 hoursTetrahymena pyriformis W was cultured in a medium composed of 2% polypepton and 0.1 % yeast extract at pH 7.2, 26°C, for 72 hours after addition of the drugs. All procedures were carried out aseptically. The growth was estimated with a photocolorimeter (Spec tronic 20, Shimadzu Seisakusho, Kyoto) at 650 m,u and the cells were counted in a Coulter counter (Model B, Coulter Co., Hialeath) which was set at an aperture current-' of 8 and amplification-' of 2.2. Experiment on the cell size distribution for one life cycle Tetrahymena was cultured in the medium for 5 days at 26°C, prior to the following experiments. The size distribution of the protozoan in which one life cycle normally took

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confidence: 99%

Effect of Compounds Affecting the Adrenergic Mechanism on Cell Growth and Division of Tetrahymena Pyriformis W

Iwata

Kariya

Fujimoto

1969

Japanese Journal of Pharmacology

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“…In an earlier communication, Janakidevi et al (1) reported that catecholamine (CA) was isolated from Tetrahymena pyriformis and the cell was also able to biosynthesize adrenaline. On the basis of these findings, Blum et al (2) started the studies on the influences of reserpine on CA content and on the growth of Tetra hymena.…”

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Variance of the Growth of Tetrahymena by the Compounds Which Affect on the Adrenergic Mechanism

1967

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In an earlier communication, Janakidevi et al. (1) reported that catecholamine (CA) was isolated from Tetrahymena pyriformis and the cell was also able to biosynthesize adrenaline. On the basis of these findings, Blum et al. (2) started the studies on the influences of reserpine on CA content and on the growth of Tetra hymena. They found that the content of CA was reduced and the growth was inhibited by the addition of re serpine.In the course of our studies on the possible physiological roles of tetrahymanol, whose structure has been established by Tsuda et al. (3), and its related substances in Tetrahymena, we have examined the influences of the compounds, which affect on the adrenergic mechanism in mammals, on the morphological changes and on the growth rate of this protozoa.The following chemicals were used in these experiments; ergotamine tartrate, dibenamine-HC1 and chlor promazine-HC1 as prototypes of a-adrenergic blocking agents, dichloroisoproterenol-HC1 (DCI) and propra nolol as R-adrenergic blocking agents, phenylethylhydrazine dihydrogen sulfate (Nardil) and R-phenylisopro pylhydrazine-HC1 (Catron) as monoamine oxidase inhibitors, reserpine phosphate as CA releaser and pyro gallol as inhibitor of catechol-O-methyl transferase. Tetrahymena pyriformis W cells were cultured in the medium composed of 2% polypepton and 0.1 % yeast extract at pH 7.2, for 72 hours at 26°C after the addition of the compounds tested. All procedures were car

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“…Epidermal growth factor (EGF) production was stimulated by histamine and serotonin [85]. Serotonin related molecules (tryptophane, 5-hydroxytryptophane) immediately after treatments diminish the serotonin content of the cells and histamine increase it [86,87]. The Tetrahymena hormone receptors are rather sensitive.…”

Section: Interhormone Relationshipsmentioning

confidence: 99%

Biogenic amines at a low level of evolution: Production, functions and regulation in the unicellular Tetrahymena

Csaba

2015

Acta Microbiologica et Immunologica Hungarica

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The unicellular eukaryote Tetrahymena synthesize, store and secrete biogenic amines (histamine, serotonin, epinephrine, dopamine, melatonin) and also can take up amines from the milieu. It also has (G-protein-coupled) receptors (binding sites) for these amines as well, as second messengers. The factors infuencing the mentioned processes are shown. For certain amines the genes and the coded enzymes are demonstrated. The amines infl uence phagocytosis, cell division, ciliary regeneration, glucose metabolism and chemotaxis. There are interhormone actions between the amines, and between the amines and other hormones produced by Tetrahymena. The critical review discusses the role of amines in the early stages of evolution and compares this to their functions in mammals. It tries to give answer how and why biogenic amines were selected to hormones, and why new functions formed for them in higher ranked animals, preserving also the ancient ones.

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Serotonin in protozoa

Cited by 68 publications

References 5 publications

Effect of Compounds Affecting the Adrenergic Mechanism on Cell Growth and Division of Tetrahymena Pyriformis W

Effect of Compounds Affecting the Adrenergic Mechanism on Cell Growth and Division of Tetrahymena Pyriformis W

Variance of the Growth of Tetrahymena by the Compounds Which Affect on the Adrenergic Mechanism

Biogenic amines at a low level of evolution: Production, functions and regulation in the unicellular Tetrahymena

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