Serotonin is essential for eye regeneration in planaria <i>Schmidtea mediterranea</i>

Sarkar, Arunabha; Mukundan, Namita; Sowndarya, Sai; Dubey, Vinay Kumar; Babu, Rosana; Lakshmanan, Vairavan; Rangiah, Kannan; Panicker, Mitradas M.; Palakodeti, Dasaradhi; Subramanian, Sabarinath Peruvemba; Subramanian, Ramaswamy

doi:10.1002/1873-3468.13607

Cited by 12 publications

(8 citation statements)

References 45 publications

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“…Serotonin transporters (SERT) terminate signaling by taking up extracellular serotonin. A homolog of the Drosophila peripheral tryptophan hydroxylase (TPH), henna , is highly expressed in both testes and ovaries, relative to the neuronally expressed tph1 (Currie and Pearson, 2013; März et al, 2013; Sarkar et al, 2019). Planarian gonads also express vmat and sert homologs, suggesting the ability to release and recycle serotonin.…”

Section: Discussionmentioning

confidence: 99%

Somatic regulation of female germ cell regeneration and development in planarians

Khan

Newmark

2021

Preprint

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SummaryFemale germ cells develop into oocytes, with the capacity for totipotency. In most animals, these remarkable cells are specified during development and cannot be regenerated. By contrast, planarians, known for their regenerative prowess, can regenerate germ cells. To uncover mechanisms required for female germ cell development and regeneration, we generated gonad-specific transcriptomes and identified genes whose expression defines progressive stages of female germ cell development. Strikingly, early female germ cells share molecular signatures with the pluripotent stem cells driving planarian regeneration. We uncovered spatial heterogeneity within somatic ovarian cells and found that a regionally enriched FoxL homolog is required for oocyte differentiation, but not specification, suggestive of functionally distinct somatic compartments. Unexpectedly, a neurotransmitter-biosynthetic enzyme, AADC, is also expressed in somatic gonadal cells, and plays opposing roles in female and male germ cell development. Thus, somatic gonadal cells deploy conserved factors to regulate germ cell development and regeneration in planarians.

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Section: Discussionmentioning

confidence: 99%

Somatic regulation of female germ cell regeneration and development in planarians

Khan

Newmark

2021

Preprint

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“…In invertebrates, such as sea urchins, mollusks, starfish, planaria and Drosophila, 5-HT is expressed early in the development and is ascribed various pre-nervous roles [8,11,[79][80][81][82]. In mammals, 5-HT is expressed at different time points in development, for e.g.…”

Section: Adhesion and Migration In Embryonic Developmentmentioning

confidence: 99%

“…While 5-HT is not known to be supplied via dietary intake or cannot cross the blood-brain barrier, dietary supplementation with tryptophan or 5-hydroxytryptophan an intermediate precursor of 5-HT can raise the blood 5-HT, and since both of these molecules can cross the blood-brain barrier it can increase 5-HT in the brain as well [7]. Moreover, 5-HT is expressed very early in the development in various invertebrates and vertebrates even before the formation of the nervous system and is reported to play a developmental role [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling

Jayakumar

Panicker

2021

Cell Adhesion & Migration

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Serotonin is well known as a neurotransmitter. Its roles in neuronal processes such as learning, memory or cognition are well established, and also in disorders such as depression, schizophrenia, bipolar disorder, and dementia. However, its effects on adhesion and cytoskeletal remodelling which are strongly affected by 5-HT receptors, are not as well studied with some exceptions for e. g. platelet aggregation. Neuronal function is strongly dependent on cell-cell contacts and adhesion-related processes. Therefore the role played by serotonin in psychiatric illness, as well as in the positive and negative effects of neuropsychiatric drugs through cell-related adhesion can be of great significance. In this review, we explore the role of serotonin in some of these aspects based on recent findings.

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“…Serotonin inducing contractions of the isolated muscle fibres in planarian Procerodes littoralis was further verified [63]. Serotonin also stimulated the development of metacestodes of E. multilocularis [64], regulating RNA synthesis in flatworms [65] and was essential for eye regeneration in planarians S. mediterranea [66] and Girardia tigrina [67], as well as accelerated growth of planarian regenerative blastema in [68]. (Kreshchenko, personal report).…”

Section: Introductionmentioning

confidence: 98%

Serotonin Signalling in Flatworms: An Immunocytochemical Localisation of 5-HT7 Type of Serotonin Receptors in Opisthorchis felineus and Hymenolepis diminuta

2021

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The study is dedicated to the investigation of serotonin (5-hydroxytryptamine, 5-HT) and 5-HT7 type serotonin receptor of localisation in larvae of two parasitic flatworms Opisthorchis felineus (Rivolta, 1884) Blanchard, 1895 and Hymenolepis diminuta Rudolphi, 1819, performed using the immunocytochemical method and confocal laser scanning microscopy (CLSM). Using whole mount preparations and specific antibodies, a microscopic analysis of the spatial distribution of 5-HT7-immunoreactivity(-IR) was revealed in worm tissue. In metacercariae of O. felineus 5-HT7-IR was observed in the main nerve cords and in the head commissure connecting the head ganglia. The presence of 5-HT7-IR was also found in several structures located on the oral sucker. 5-HT7-IR was evident in the round glandular cells scattered throughout the larva body. In cysticercoids of H. diminuta immunostaining to 5-НТ7 was found in flame cells of the excretory system. Weak staining to 5-HT7 was observed along the longitudinal and transverse muscle fibres comprising the body wall and musculature of suckers, in thin longitudinal nerve cords and a connective commissure of the central nervous system. Available publications on serotonin action in flatworms and serotonin receptors identification were reviewed. Own results and the published data indicate that the muscular structures of flatworms are deeply supplied by 5-HT7-IR elements. It suggests that the 5-HT7 type receptor can mediate the serotonin action in the investigated species and is an important component of the flatworm motor control system. The study of the neurochemical basis of parasitic flatworms can play an important role in the solution of fundamental problems in early development of the nervous system and the evolution of neuronal signalling components.

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Serotonin is essential for eye regeneration in planaria Schmidtea mediterranea

Cited by 12 publications

References 45 publications

Somatic regulation of female germ cell regeneration and development in planarians

Somatic regulation of female germ cell regeneration and development in planarians

The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling

Serotonin Signalling in Flatworms: An Immunocytochemical Localisation of 5-HT7 Type of Serotonin Receptors in Opisthorchis felineus and Hymenolepis diminuta

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