Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures

Pardo-Peña, Kenia; Medina‐Ceja, Laura; Morales‐Villagrán, Alberto

doi:10.1016/j.brainres.2014.07.049

Cited by 12 publications

(9 citation statements)

References 60 publications

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“…This monoamine is important in many behaviors, including sleep, appetite, memory, sexual behavior, neuroendocrine function, and mood (Sghendo and Mifsud, 2012). It also interferes in food behavior, promoting satiety and reducing body weight ( [Guimarães et al, 2006,Voigt andFink, 2015]) and seems to decrease brain excitability ([Pardo-Peña et al, 2014,Tarlaci, 2009). …”

Section: Introductionmentioning

confidence: 96%

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Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Monteiro

Barreto-Silva

Santos

et al. 2015

European Journal of Pharmacology

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The antidepressant fluoxetine and physical exercise exert similar effects on the serotoninergic system by increasing brain serotonin availability, and both show antagonistic action on cortical excitability. Here we provide the first assessment of the interaction of the two together on cortical spreading depression (CSD) in young adult rats. Wistar rats (40-60 days of life) received fluoxetine (10mg/kg/d, orogastrically) or an equivalent volume of water. Half of the animals from each condition were assigned to perform physical exercise in a treadmill, and the other half formed the sedentary (non-treadmill) control groups. Body parameters (Lee index and thoracic and abdominal circumferences) and the velocity of CSD propagation were investigated. Fluoxetine+exercise animals had less weight gain (78.68±3.19g) than either the fluoxetine-only (93.34±4.77g) or exercise-only group (97.04±3.48g), but body parameters did not differ among them. The velocity of CSD propagation was reduced in the fluoxetine-only and exercise-only groups compared to sedentary water controls (3.24±0.39mm/min). For the fluoxetine+exercise group, CSD velocity values were significantly lower (2.92±0.22mm/min) than for fluoxetine only (3.03±0.35mm/min); however, they were similar to values for the exercise-only group (2.96±0.23mm/min). These findings confirm the similar effects of fluoxetine and exercise and suggest a greater effect of physical exercise in reducing brain excitability.

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Section: Introductionmentioning

confidence: 96%

“…Citalopram can reduce the occurrence of spontaneous high-frequency oscillations that occur in epileptic seizures (Pardo-Peña et al, 2014). Escitalopram promotes a decreased frequency, duration, and intensity of episodes of migraine (Tarlaci, 2009).…”

Section: Introductionmentioning

confidence: 98%

Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Monteiro

Barreto-Silva

Santos

et al. 2015

European Journal of Pharmacology

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“…Citalopram exerts a significant modulatory effect on fast ripple activity in rats with spontaneous recurrent seizures and decreases that in patients with temporal lobe epilepsy [12]. It also reduces seizure frequency in rats with chronic epilepsy induced by kainic acid [13].…”

Section: To the Editormentioning

confidence: 98%

Citalopram as a good candidate for treatment of depression in patients with epilepsy

Payandemehr

Ghasemi

Dehpour

2015

Epilepsy & Behavior

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“…In addition to correlation analysis, some inference can be made from the observed effects of antidepressant drugs on experimental epilepsy. Most experimental studies have shown that SSRIs, native serotonin molecule, and norepinephrine reuptake inhibitors (NERIs) exert antiepileptic effects in animal models of TLE, including kindling, pilocarpine, and kainic acid models.…”

Section: Complex Relation Between Common Psychiatric Comorbidities Anmentioning

confidence: 99%

Bidirectional relations among common psychiatric and neurologic comorbidities and epilepsy: Do they have an impact on the course of the seizure disorder?

Kanner

Ribot

Mazarati³

2018

Epilepsia Open

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SummaryThe treatment of epilepsy is not limited to the achievement of a seizure‐free state. It must also incorporate the management of common psychiatric and neurologic comorbidities, affecting on average between 30 and 50% of patients with epilepsy, which have a significant impact on their lives at various levels, including quality of life and the prognosis of the seizure disorder. Mood and anxiety disorders are the most frequent psychiatric comorbidities, whereas stroke and migraine are among the more common neurologic comorbidities, migraine among the younger patients and stroke among the older patients. Not only do these psychiatric and neurologic comorbidities each have a bidirectional relation with epilepsy, but primary mood disorders have a bidirectional relation with these 2 neurologic disorders. Furthermore, depression and migraine have been each associated with a more severe epilepsy course, whereas depression has been associated with a more severe course of stroke and migraines. The purpose of this article is to review the clinical implications of the complex relations among epilepsy and these 3 comorbid disorders, and to identify any clinical and/or experimental evidence that may suggest that having more than one of these comorbid disorders may increase the risk of and course of epilepsy.

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Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures

Cited by 12 publications

References 60 publications

Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Citalopram as a good candidate for treatment of depression in patients with epilepsy

Bidirectional relations among common psychiatric and neurologic comorbidities and epilepsy: Do they have an impact on the course of the seizure disorder?

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