Serotonin, neural markers, and memory

Meneses, Alfredo

doi:10.3389/fphar.2015.00143

Cited by 75 publications

(43 citation statements)

References 226 publications

(334 reference statements)

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“…In addition, knowledge gained from neuroimaging studies (Binder and Desai, 2011), as well as knowledge of the neural markers associated with memory (Meneses, 2015), will likely play a key role in future models of memory mechanisms, but in this review, as stated above, we focus mainly on neuroanatomical, neurophysiological, and psychological mechanisms.…”

Section: Introductionmentioning

confidence: 99%

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

2017

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This review aims to classify and clarify, from a neuroanatomical, neurophysiological, and psychological perspective, different memory models that are currently widespread in the literature as well as to describe their origins. We believe it is important to consider previous developments without which one cannot adequately understand the kinds of models that are now current in the scientific literature. This article intends to provide a comprehensive and rigorous overview for understanding and ordering the latest scientific advances related to this subject. The main forms of memory presented include sensory memory, short-term memory, and long-term memory. Information from the world around us is first stored by sensory memory, thus enabling the storage and future use of such information. Short-term memory (or memory) refers to information processed in a short period of time. Long-term memory allows us to store information for long periods of time, including information that can be retrieved consciously (explicit memory) or unconsciously (implicit memory).

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Section: Introductionmentioning

confidence: 99%

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

2017

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“…Recent evidence suggests that the serotonin [5-hydroxytryptamine (5-HT)] system encompassing 14 subtypes of 5-HT receptors not only plays a key role in the regulation of mood, affect, learning, and memory (2,9,10), but is also implicated in social cognition (11,12). Psilocybin [4-phosphoryloxy-N,N-dimethyltryptamine (Psi)] is a serotonergic hallucinogen that induces an altered state of consciousness characterized by changes in sensory perception, emotion, thought, and the sense of self in a dose-dependent manner (13).…”

mentioning

confidence: 99%

Effects of serotonin 2A/1A receptor stimulation on social exclusion processing

Preller¹,

Pokorny²,

Höck

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

141

103

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Social ties are crucial for physical and mental health. However, psychiatric patients frequently encounter social rejection. Moreover, an increased reactivity to social exclusion influences the development, progression, and treatment of various psychiatric disorders. Nevertheless, the neuromodulatory substrates of rejection experiences are largely unknown. The preferential serotonin (5-HT) 2A/1A receptor agonist, psilocybin (Psi), reduces the processing of negative stimuli, but whether 5-HT2A/1A receptor stimulation modulates the processing of negative social interactions remains unclear. Therefore, this double-blind, randomized, counterbalanced, cross-over study assessed the neural response to social exclusion after the acute administration of Psi (0.215 mg/kg) or placebo (Pla) in 21 healthy volunteers by using functional magnetic resonance imaging (fMRI) and resting-state magnetic resonance spectroscopy (MRS). Participants reported a reduced feeling of social exclusion after Psi vs. Pla administration, and the neural response to social exclusion was decreased in the dorsal anterior cingulate cortex (dACC) and the middle frontal gyrus, key regions for social pain processing. The reduced neural response in the dACC was significantly correlated with Psi-induced changes in selfprocessing and decreased aspartate (Asp) content. In conclusion, 5-HT2A/1A receptor stimulation with psilocybin seems to reduce social pain processing in association with changes in self-experience. These findings may be relevant to the normalization of negative social interaction processing in psychiatric disorders characterized by increased rejection sensitivity. The current results also emphasize the importance of 5-HT2A/1A receptor subtypes and the Asp system in the control of social functioning, and as prospective targets in the treatment of sociocognitive impairments in psychiatric illnesses.social cognition | serotonin | psilocybin | functional magnetic resonance imaging | magnetic resonance spectroscopy

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“…Furthermore, 5HT 1A -knockout mice exhibit increased stress responses (Klemenhagen et al 2006). Additionally, numerous studies using agonists and/or antagonists of 5-HT 1A/1B , 5-HT 2A/2C , 5-HT 3 , 5-HT 4 , 5-HT 6 , and 5-HT 7 receptors have illustrated their promnesic and/or antiamnesic effects (Meneses 2015). Therefore, it seems likely that diverse 5-HT receptors are involved in the pathophysiological mechanisms of PTSD.…”

Section: Discussionmentioning

confidence: 98%

Contribution of Hippocampal 5-HT3 Receptors in Hippocampal Autophagy and Extinction of Conditioned Fear Responses after a Single Prolonged Stress Exposure in Rats

Yang

Cui

et al. 2016

Cell Mol Neurobiol

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One of the hypotheses about the pathogenesis of posttraumatic stress disorder (PTSD) is the dysfunction of serotonin (5-HT) neurotransmission. While certain 5-HT receptor subtypes are likely critical for the symptoms of PTSD, few studies have examined the role of 5-HT receptor in the development of PTSD, even though 5-HT receptor is critical for contextual fear extinction and anxiety-like behavior. Therefore, we hypothesized that stimulation of 5-HT receptor in the dorsal hippocampus (DH) could prevent hippocampal autophagy and the development of PTSD-like behavior in animals. To this end, we infused SR57227, selective 5-HT agonist, into the DH after a single prolonged stress (SPS) treatment in rats. Three weeks later, we evaluated the effects of this pharmacological treatment on anxiety-related behaviors and extinction of contextual fear memory. We also accessed hippocampal autophagy and the expression of 5-HT subunit, Beclin-1, LC3-I, and LC3-II in the DH. We found that SPS treatment did not alter anxiety-related behaviors but prolonged the extinction of contextual fear memory, and such a behavioral phenomenon was correlated with increased hippocampal autophagy, decreased 5-HT expression, and increased expression of Beclin-1 and LC3-II/LC3-I ratio in the DH. Furthermore, intraDH infusions of SR57227 dose-dependently promoted the extinction of contextual fear memory, prevented hippocampal autophagy, and decreased expression of Beclin-1 and LC3-II/LC3-I ratio in the DH. These results indicated that 5-HT receptor in the hippocampus may play a critical role in the pathogenesis of hippocampal autophagy, and is likely involved in the pathophysiology of PTSD.

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Serotonin, neural markers, and memory

Cited by 75 publications

References 226 publications

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins

Effects of serotonin 2A/1A receptor stimulation on social exclusion processing

Contribution of Hippocampal 5-HT3 Receptors in Hippocampal Autophagy and Extinction of Conditioned Fear Responses after a Single Prolonged Stress Exposure in Rats

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