Serotonin receptor subtypes influence prolactin secretion in the turkey

Chaiseha, Yupaporn; Kang, Seong Wook; Leclerc, B.; Kosonsiriluk, Sunantha; Sartsoongnoen, Natagarn; Halawani, Mohamed E. El

doi:10.1016/j.ygcen.2009.06.018

Cited by 13 publications

(6 citation statements)

References 35 publications

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“…However, PET ligands are generally unable to detect desensitization of a receptor, and thus it is impossible to determine the functional status of a receptor solely with a PET scan. The 5HT2A receptor is involved in both mediating the prolactin response (Chaiseha et al, 2010;Jorgensen, 2007) and facilitating DA release (Bubar and Cunningham, 2008); therefore an increase in the prolactin response as well as in DA overflow would be expected. However, both the prolactin response and cocaine-induced DA overflow decreased with no change in the amount of 5HT overflow, suggesting that these receptors may in fact be desensitized.…”

Section: Neurobiological Mechanismsmentioning

confidence: 99%

Neurobiological Changes Mediating the Effects of Chronic Fluoxetine on Cocaine Use

Mun

Nye

Kimmel

et al. 2012

Neuropsychopharmacol

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Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration. In order to better understand the role of serotonin (5HT) in cocaine abuse and treatment, we examined the effects of chronic treatment with the SSRI fluoxetine at clinically relevant serum concentrations on cocaine-related neurobiology and behavior. Rhesus macaques self-administering cocaine underwent a 6-week dosing regimen with fluoxetine designed to approximate serum concentrations observed in humans. Self-administration and reinstatement were monitored throughout the treatment and washout period. In vivo microdiaylsis was used to assess changes in dopaminergic and serotonergic neurochemistry. Positron emission tomography was used to assess changes in the 5HT transporter and 2A receptor binding potential (BP). Functional output of the 5HT system was assessed using prolactin levels. Cocaine-primed reinstatement and cocaine-elicited dopamine overflow were significantly suppressed following chronic fluoxetine treatment. 5HT2A receptor BP was increased in the frontal cortex following treatment while prolactin release was blunted, suggesting desensitization of the 5HT2A receptor. These effects persisted after a 6-week washout period. Measures of pre-synaptic serotonergic function and cocaine self-administration were unaffected. These data demonstrate that acute and chronic fluoxetine treatments exert different effects on cocaine-related behavior. Furthermore, chronic fluoxetine treatment causes alterations in 5HT2A receptors in the frontal cortex that may selectively disrupt cocaine-primed reinstatement. Fluoxetine may not be useful for treatment of ongoing cocaine abuse but may be useful in relapse prevention.

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Section: Neurobiological Mechanismsmentioning

confidence: 99%

Neurobiological Changes Mediating the Effects of Chronic Fluoxetine on Cocaine Use

Mun

Nye

Kimmel

et al. 2012

Neuropsychopharmacol

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“…Furthermore, the stimulatory effect of the VIP on PRL synthesis and release is mediated by receptors in the pituitary gland ( Rozenboim and El Halawani, 1993 , Chaiseha et al, 2010 ), and their abundance correlates with circulating PRL levels during the different reproductive stages in turkeys ( Youngren et al, 1996 , Chaiseha et al, 2004 ). Thus, it seems plausible that lack of differences in pituitary PRL mRNA expression between the control and PCPA-treated hens could be also partly attributable to pituitary VIP receptor–level stability during the reproductive cycle in native Polish crested chickens.…”

Section: Discussionmentioning

confidence: 99%

The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness

Gumułka¹,

Hrabia²,

Avital-Cohen³

et al. 2020

Poultry Science

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Brooding behavior, a common characteristic of native breeds of the domestic chicken, is marked by elevated prolactin ( PRL ) levels, which is necessary for incubation and connected with changes in hypothalamic–pituitary–gonadal axis activity. Evidence indicates the serotoninergic system is a potent modulator of PRL secretion. The objective of this study is to investigate whether blocking serotonin synthesis with parachlorophenylalanine ( PCPA ) prevents incubation behavior in native Polish crested chickens. In addition, we examined the effect of PCPA on the gene expression of the gonadal and lactotrophic axes. Birds were stimulated to broodiness by artificial eggs in nests. At 34 wk of age (April: spring period), the hens were divided into 2 groups (14 hens in each group): control and PCPA-treated (50 mg/kg BW) group. After 5 wk of treatment, the artificial eggs were removed from the nests. Egg production, incubation activity, and levels of plasma ovarian steroids progesterone ( P4 ), testosterone ( T ), estradiol ( E2 ), and PRL were examined. At the end of the experiment (45 wk of age, June: summer period), ovarian characteristics and mRNA gene expression of gonadal (gonadotropin-releasing hormone [ GnRH ] I, luteinizing hormone [ LH ] ß, follicle-stimulating hormone [ FSH ] ß) and lactotrophic (vasoactive intestinal peptide [ VIP ], PRL) axes were measured by quantitative real-time PCR. Incubation activity was observed in the hens of both groups but with lower frequency in PCPA-treated birds. Moreover, the PCPA group had a higher cumulative egg production than the controls. During the first six and 8 wk of the experiment, levels of P4 and E2, respectively, were similar in both groups, but all concentrations increased in the PCPA-treated hens after this period. In addition, increased GnRH-I, LHß, and FSHß and decreased VIP mRNA expression was observed in the PCPA group compared with the controls. There were no differences in PRL mRNA expression, the PRL level, and ovarian morphometry between the 2 groups. These results indicate that blockage of serotonin synthesis by PCPA does not effectively prevent incubation in native Polish crested chickens. However, treatment with PCPA increased gonadal axis activity and improved reproductive performance.

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“…Some studies have linked higher central (Leckman et al, 1994) and peripheral (Humble et al, 2013) oxytocin levels to OCD, whereas others have found no significant correlation with endogenous oxytocin levels (Altemus et al, 1999) or effect on OCD symptomology after exogenous administration of oxytocin (den Boer and Westenberg, 1992;Epperson et al, 1996). Interactions between oxytocin and the central and peripheral serotonergic systems (Jury et al, 2015), such as serotonergic-mediated modulation of prolactin secretion (Balsa et al, 1998;Chaiseha et al, 2010), might underlie these responses. However, plasma prolactin levels in patients with OCD after challenge with mCPP have been contradictory (den Boer and Westenberg, 1992;Leckman et al, 1994;Epperson et al, 1996;Altemus et al, 1999;Khanna et al, 2001;Humble et al, 2013), and further study as to the role of this neuropeptide in OCD is warranted.…”

Section: B Probing the Role Of Other Endogenous Processes In Obsessive-compulsive Disordermentioning

confidence: 99%

The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap

Szechtman

Harvey

Woody

et al. 2020

Pharmacological Reviews

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Servier and has received research funding from Servier and Lundbeck. Except for income from the primary employer and research funding to B.H.H. from the above-mentioned organizations and agencies, no financial support or compensation has been received from any individual or corporate entity over the past 3 years for research or professional services, and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest.

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Serotonin receptor subtypes influence prolactin secretion in the turkey

Cited by 13 publications

References 35 publications

Neurobiological Changes Mediating the Effects of Chronic Fluoxetine on Cocaine Use

Neurobiological Changes Mediating the Effects of Chronic Fluoxetine on Cocaine Use

The effect of parachlorophenylalanine treatment on the activity of gonadal and lactotrophic axes in native Polish crested chickens stimulated to broodiness

The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap

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