Serotonin Transporter Binding in Bipolar Disorder Assessed using [11C]DASB and Positron Emission Tomography

Cannon, Dara M.; Ichise, Masanori; Fromm, Stephen J.; Nugent, Allison C.; Rollis, Denise; Gandhi, Shilpa K.; Klaver, Jacqueline M.; Charney, Dennis S.; Manji, Husseini K.; Drevets, Wayne C.

doi:10.1016/j.biopsych.2006.05.005

Cited by 180 publications

(116 citation statements)

References 80 publications

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“…DRN neurons provide a tonic firing pattern related to expected and received reward values, whereas SN/VTA neurons exhibit phasic responses related to reward-prediction errors. The PRN also plays a critical role in affective regulatory functions [47][48][49][50]. Patients with bipolar disorders exhibit reduced serotonergic functioning in the PRN [47,48], and both the anatomical and functional connectivity of the PRN with other affective networks predicts the affective states and emotional reactivity of healthy persons [49].…”

Section: Discussionmentioning

confidence: 99%

Brainstem Activity Predicts Attachment-Related Anxiety

Kikuchi¹,

Matsutani²,

Mori³

et al. 2018

Neuropsychiatry

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Objective: Attachment security serves as a critical resource for individuals to preserve relationship quality. However, insecure attachment interrupts it and seriously influences mental/physical health. Therefore, it is important to clarify the correlations between brain activity and attachment-related anxiety and its avoidance. Methods:We investigated these correlations in healthy male subjects by using functional magnetic resonance imaging (fMRI) while they were viewing their partner.Results: The brain regions that were significantly activated for the partner vs. unknown females were the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), dorsal raphe nucleus (DRN), pontine raphe nucleus (PRN), and locus coeruleus (LC) in a whole-brain analysis. A region of interest (ROI) analysis showed that the DRN, periaqueductal grey (PAG), hypothalamus, anterior insula (AIC), substantia nigra/ventral tegmental area (SN/VTA), ACC, PCC and intraparietal sulcus (IPS) were significantly activated. Furthermore, activity in the DRN, SN/VTA, and LC negatively correlated with attachment-related anxiety.Conclusions: There were individual differences in the correlations between the brainstem activity and attachment-related anxiety, although brain activity in our subjects was more similar to that observed in long-term intense romantic love and maternal love compared to that in early-stage romantic love. These brainstem regions are the primary sites of neurotransmitters which modulate basic functions of survival, and also play key roles for maintenance of secure relationships with a partner. This finding might be useful to assessment of the risk of breakdowns by factors of the attachment style.

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Section: Discussionmentioning

confidence: 99%

Brainstem Activity Predicts Attachment-Related Anxiety

Kikuchi¹,

Matsutani²,

Mori³

et al. 2018

Neuropsychiatry

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“…Investigators from USA analyzed the serotonin transporter (5-HTT) binding potential (BP) using positron-emission tomography (PET) and [ 11 C] DASB, a radioligand with high sensitivity and specificity for 5-HTT. They reported higher 5-HTT binding potential in OCD-BD subjects as compared to non-OCD-BD in the insula, in the posterior cingular cortex, in the subgenual anterior cingulate cortex, and in the dorsal cingulate cortex (77).…”

Section: Included Studiesmentioning

confidence: 96%

Diagnostic validity of comorbid bipolar disorder and obsessive–compulsive disorder: a systematic review

Amerio

Odone

Liapis

et al. 2014

Acta Psychiatr Scand

107

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Diagnostic validity of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review Amerio A, Odone A, Liapis CC, Ghaemi SN. Diagnostic validity of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review.Objective: At least 50% of bipolar disorder (BD) patients have an additional diagnosis, one of the most difficult to manage being obsessive-compulsive disorder (OCD). Defining the nosology of BD-OCD comorbidity has important clinical implications, given that treatments for OCD can worsen BD outcomes. Method: A systematic review was conducted on: i) BD-OCD comorbidity lifetime prevalence and ii) on standard diagnostic validators: phenomenology, course of illness, heredity, biological markers, and treatment response. Relevant papers published through March 30th 2013 were identified searching the electronic databases MEDLINE, Embase, PsycINFO, and the Cochrane Library. Results: Sixty-four articles met inclusion criteria. Lifetime comorbidity prevalence was 11-21% in BD patients and 6-10% in OCD patients. Compared to non-comorbid subjects, BD-OCD has a more episodic course of OC symptoms (up to 75% vs. 3%), typically with worsening during depression (78%) and improvement during mania/hypomania (64%), as well as a higher total mean number of depressive episodes (8.9 AE 4.2 vs. 4.1 AE 2.7) and perhaps more antidepressant-induced mania/hypomania (39% vs. 9%). Conclusion: In this first systematic review of BD-OCD comorbidity, it appears that OC symptoms are usually secondary to BD, rather than representing a separate disease. • The evidence so far on BD-OCD nosology-mainly based on the course of illness-supports the view that the majority of cases of comorbid BD-OCD are in fact cases of BD. OC symptoms usually are secondary manifestations of depressive or manic mood episodes.• BD-OCD patients may respond for both groups of symptoms with adequate doses of mood stabilizers and atypical antipsychotics. Because of the risk of worsening BD via SRI-induced mania/hypomania, antidepressants should only be used in a minority of refractory OCD. Considerations• Course of illness is the only diagnostic validator that clearly supports the OCD-BD construct as a subtype of BD. Findings on the phenomenology, heredity, biological markers, and treatment were fragmented and heterogeneous and mainly suggested increased severity of illness or functioning without helping us to answer the nosological question.• The use of retrospective assessment scales with unclear sensitivity in discriminating true ego-dystonic obsessions from depressive ruminations may have biased results toward an overestimation of obsession's prevalence. In addition, small sample sizes, mainly from out-patients units, may have limited the generalizability of the results to a whole community.

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“…10 Positron emission tomography (PET) with [ 11 C]DASB and [ 18 F]altanserin has widely been used to investigate the availability of serotonin transporter (SERT) and serotonin receptor 5-HT 2A in both humans and animals. [11][12][13][14] This imaging method has proven to be helpful in elucidating the role of serotoninergic mechanisms in aging, 15 and neurologic and psychiatric pathologies such as Alzheimer's disease, 16 depression 17,18 obsessive-compulsive disorder, 19 bipolar disorder, 20 and schizophrenia. 21 Nevertheless, the role of serotoninergic neurotransmission in stroke evolution using PET imaging has scarcely been explored to date.…”

Section: Introductionmentioning

confidence: 99%

PET Imaging of Serotoninergic Neurotransmission with [¹¹C]DASB and [¹⁸F]altanserin after Focal Cerebral Ischemia in Rats

Martín

Szczupak

Gómez‐Vallejo

et al. 2013

J Cereb Blood Flow Metab

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The use of selective serotonin reuptake inhibitors has shown functional improvement after stroke. Despite this, the role of serotoninergic neurotransmission after cerebral ischemia evolution and its involvement in functional recovery processes are still largely unknown. For this purpose, we performed in parallel in vivo magnetic resonance imaging and positron emission tomography (PET) with [ 11 C]DASB and [ 18 F]altanserin at 1, 3, 7, 14, 21, and 28 days after middle cerebral artery occlusion (MCAO) in rats. In the ischemic territory, PET with [ 11 C]DASB and [ 18 F]altanserin showed a dramatic decline in serotonin transporter (SERT) and 5-HT 2A binding potential in the cortex and striatum after cerebral ischemia. Interestingly, a slight increase in [ 11 C]DASB binding was observed from days 7 to 21 followed by the uppermost binding at day 28 in the ipsilateral midbrain. In contrast, no changes were observed in the contralateral hemisphere by using both radiotracers. Likewise, both functional and behavior testing showed major impaired outcome at day 1 after ischemia onset followed by a recovery of the sensorimotor function and dexterity from day 21 to day 28 after cerebral ischemia. Taken together, these results might evidence that SERT changes in the midbrain could have a key role in the functional recovery process after cerebral ischemia.

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Serotonin Transporter Binding in Bipolar Disorder Assessed using [11C]DASB and Positron Emission Tomography

Cited by 180 publications

References 80 publications

Brainstem Activity Predicts Attachment-Related Anxiety

Brainstem Activity Predicts Attachment-Related Anxiety

Diagnostic validity of comorbid bipolar disorder and obsessive–compulsive disorder: a systematic review

PET Imaging of Serotoninergic Neurotransmission with [¹¹C]DASB and [¹⁸F]altanserin after Focal Cerebral Ischemia in Rats

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Serotonin Transporter Binding in Bipolar Disorder Assessed using [11C]DASB and Positron Emission Tomography

Cited by 180 publications

References 80 publications

Brainstem Activity Predicts Attachment-Related Anxiety

Brainstem Activity Predicts Attachment-Related Anxiety

Diagnostic validity of comorbid bipolar disorder and obsessive–compulsive disorder: a systematic review

PET Imaging of Serotoninergic Neurotransmission with [11C]DASB and [18F]altanserin after Focal Cerebral Ischemia in Rats

Contact Info

Product

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About

PET Imaging of Serotoninergic Neurotransmission with [¹¹C]DASB and [¹⁸F]altanserin after Focal Cerebral Ischemia in Rats