Serotonin transporter gene polymorphism (5-HTTLPR) and emotional response to auditory hallucinations in schizophrenia

Sanjuán, Julio; Rivero, Olga; Aguilar, Eduardo J.; González, J.; Moltó, María Dolores; Frutos, Rosa de; Lesch, Klaus‐Peter; Nájera, Carmén

doi:10.1017/s1461145705005559

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…While the 5-HTT long allele (L), associated with increased transcriptional activity of the gene—ie, responsible for increasing the recapture of serotonin in the synaptic cleft—has been associated with AVH intensity, 62 a second study demonstrated that the implication of the short allele (S) of the 5-HTT gene was specifically linked with increased emotional reactions and emotional distress in reaction to AVH. 63 …”

Section: Factors Associated With Hallucinations In Children and Adolementioning

confidence: 99%

From Phenomenology to Neurophysiological Understanding of Hallucinations in Children and Adolescents

Jardri

Bartels-Velthuis

Debbané

et al. 2014

Schizophrenia Bulletin

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Typically reported as vivid, multisensory experiences which may spontaneously resolve, hallucinations are present at high rates during childhood. The risk of associated psychopathology is a major cause of concern. On the one hand, the risk of developing further delusional ideation has been shown to be reduced by better theory of mind skills. On the other hand, ideas of reference, passivity phenomena, and misidentification syndrome have been shown to increase the risk of self-injury or heteroaggressive behaviors. Cognitive psychology and brain-imaging studies have advanced our knowledge of the mechanisms underlying these early-onset hallucinations. Notably, specific functional impairments have been associated with certain phenomenological characteristics of hallucinations in youths, including intrusiveness and the sense of reality. In this review, we provide an update of associated epidemiological and phenomenological factors (including sociocultural context, social adversity, and genetics, considered in relation to the psychosis continuum hypothesis), cognitive models, and neurophysiological findings concerning hallucinations in children and adolescents. Key issues that have interfered with progress are considered and recommendations for future studies are provided.

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Section: Factors Associated With Hallucinations In Children and Adolementioning

confidence: 99%

From Phenomenology to Neurophysiological Understanding of Hallucinations in Children and Adolescents

Jardri

Bartels-Velthuis

Debbané

et al. 2014

Schizophrenia Bulletin

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show abstract

“…Recientemente, hemos investigado si un polimorfismo funcional del gen SLC6A4 (5-HTTLPR) estaba asociado con las alucinaciones auditivas en pacientes psicóticos [6]. Este polimorfismo, situado en una región repetitiva que modula la actividad transcripcional, consta de una variante larga de 16 repeticiones (alelo l) y una variante corta de 14 repeticiones (alelo s), esta última con una menor actividad transcripcional [18].…”

Section: Palabrasunclassified

“…Este polimorfismo, situado en una región repetitiva que modula la actividad transcripcional, consta de una variante larga de 16 repeticiones (alelo l) y una variante corta de 14 repeticiones (alelo s), esta última con una menor actividad transcripcional [18]. En nuestro estudio preliminar [6], concluimos que los pacientes con al menos una copia del alelo s mostraban una mayor respuesta emocional frente a las AA. Estos resultados son coherentes con estudios previos de otros autores [19,20].…”

Section: Palabrasunclassified

“…El alelo s de baja expresión se ha descrito como una variante de riesgo para trastornos afectivos [25,41]. Además, nuestro hallazgo es también coherente con nuestro trabajo preliminar [6], donde se encontraron asociaciones significativas entre el alelo s del 5-HTTLPR y los parámetros de la escala PSYRATS de AA que evaluaban la respuesta emocional. Las aproximaciones de neuroimagen funcional también son de gran interés.…”

Section: Genotipo 5-httlprunclassified

“…El presente estudio es parte de una aproximación que integra hallazgos fenomenológicos [5], genéticos [6,7] y de neuroimagen [8], en un intento de comprender las bases neurobiológicas de las AA de los pacientes psicóticos. Curiosamente, la mayoría de los estudios sobre la genética de las alucinaciones se han realizado en pacientes neurológicos [9,10].…”

Section: Introductionunclassified

See 2 more Smart Citations

Variación en el gen del transportador de serotonina y alucinaciones auditivas en la psicosis

Rivero

Sanjuán²,

Aguilar³

et al. 2010

RevNeurol

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Candidate Genes Involved in the Expression of Psychotic Symptoms: A Focus on Hallucinations

Sanjuán

Moltó²,

Tolosa

2012

The Neuroscience of Hallucinations

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Serotonin transporter gene polymorphism (5-HTTLPR) and emotional response to auditory hallucinations in schizophrenia

Cited by 13 publications

References 9 publications

From Phenomenology to Neurophysiological Understanding of Hallucinations in Children and Adolescents

From Phenomenology to Neurophysiological Understanding of Hallucinations in Children and Adolescents

Variación en el gen del transportador de serotonina y alucinaciones auditivas en la psicosis

Candidate Genes Involved in the Expression of Psychotic Symptoms: A Focus on Hallucinations

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