Serotypes of Streptococcus pneumoniae Isolates from Children with Invasive Pneumococcal Disease in Turkey: Baseline Evaluation of the Introduction of the Pneumococcal Conjugate Vaccine Nationwide

Ceyhan, Mehmet; Gürler, Nezahat; Yaman, Akgün; Öztürk, Candan; Öksüz, Lütfiye; Özkan, Şengül; Keser, Melike; Salman, Nuran; Alhan, Emre; Eşel, Duygu; Gültekin, Meral; Camcioğlu, Yıldız; Gül, Mustafa; Sorguç, Yelda; Aydemir, Şöhret; Günaydın, Murat; Yakupoğulları, Yusuf; Kizirgil, Ahmet

doi:10.1128/cvi.00526-10

Cited by 16 publications

(18 citation statements)

References 23 publications

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“…Serotype 19F was also prevailing serotype in prevaccine era for children from neighbouring countries such as Turkey and Greece. 15,16 In many European countries, the most common serotype in children with IPD was reported to be serotype 14. 9,17,18 The coverage of PCV7 (64.2%) in the Bulgarian population below 5 years is similar to many European countries before the introduction of mass vaccination.…”

Section: Discussionmentioning

confidence: 99%

Serotype distribution and antimicrobial resistance of invasiveStreptococcus pneumoniaeisolates in Bulgaria before the introduction of pneumococcal conjugate vaccine

Setchanova

Alexandrova

Mitov

et al. 2012

Journal of Chemotherapy

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The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced as a mandatory vaccine in Bulgaria in April 2010. We report on the serotype distribution and the antimicrobial resistance of 222 invasive Streptococcus pneumoniae isolates collected from all age groups before the introduction of PCV10. PCV7, PCV10, and PCV13 covered 43.7, 59.9, and 78.8% of all invasive pneumococcal strains, and 64.2, 79.1, and 89.6% of isolates involving children less than 5 years of age. Penicillin resistance was found in 30.1% of the isolates responsible for meningitis and in 5.0% of isolates responsible for other invasive infections. Overall, erythromycin resistance was found in 19.4% of all invasive strains. The erm(B) was the most prevalent pneumococcal macrolide resistance genotype (63.2%) and dual mechanisms of both genes the erm(B) and mef(E) were detected in 15.8% of 19 erythromycin resistant isolates during the period 2006-2010. The prevalence and spread of serotypes 19F, 6B, and 19A during the last period may have contributed to the high predominance of erm(B) genotype in comparison of mef genotype, which was predominant in our country among erythromycin-resistant isolates before 2005. Continuing surveillance is required after the recent introduction of PCV10 in order to observe future developments of any serotype changes in the Bulgarian population, as well as surveillance of antimicrobial susceptibility of invasive S. pneumoniae isolates.

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Section: Discussionmentioning

confidence: 99%

Serotype distribution and antimicrobial resistance of invasiveStreptococcus pneumoniaeisolates in Bulgaria before the introduction of pneumococcal conjugate vaccine

Setchanova

Alexandrova

Mitov

et al. 2012

Journal of Chemotherapy

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“…In adults, serotypes 3 and 19A were most frequent in 2011–12, with 7F and 6B increasing in incidence in 2013 47 . In Turkey, PCV7 was introduced in 2008 and the most common IPD serotypes in children ≤ 2 years in 2008–10 were 19F and 6B 52 . In 2011–12, before the switch to PCV13, the serotype distribution had changed, with serotypes 3, 6A and 19A being the most prevalent 62 …”

Section: Pneumococcal Disease In Central and Eastern European Countriesmentioning

confidence: 99%

Surveillance of pneumococcal diseases in Central and Eastern Europe

Ceyhan

Dagan

Sayıner

et al. 2016

Human Vaccines & Immunotherapeutics

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Pneumococcal infection is a major cause of morbidity and mortality worldwide. The burden of disease associated with S. pneumoniae is largely preventable through routine vaccination. Pneumococcal conjugate vaccines (e.g. PCV7, PCV13) provide protection from invasive pneumococcal disease as well as non-invasive infection (pneumonia, acute otitis media), and decrease vaccine-type nasopharyngeal colonisation, thus reducing transmission to unvaccinated individuals. PCVs have also been shown to reduce the incidence of antibiotic-resistant pneumococcal disease. Surveillance for pneumococcal disease is important to understand local epidemiology, serotype distribution and antibiotic resistance rates. Surveillance systems also help to inform policy development, including vaccine recommendations, and monitor the impact of pneumococcal vaccination. National pneumococcal surveillance systems exist in a number of countries in Central and Eastern Europe (such as Croatia, Czech Republic, Hungary, Poland, Romania and Slovakia), and some have introduced PCVs (Czech Republic, Hungary, Kazakhstan, Russia, Slovakia and Turkey). Those countries without established programs (such as Kazakhstan, Russia and Ukraine) may be able to learn from the experiences of those with national surveillance systems. The serotype distributions and impact of PCV13 on pediatric pneumococcal diseases are relatively similar in different parts of the world, suggesting that approaches to vaccination used elsewhere are also likely to be effective in Central and Eastern Europe. This article briefly reviews the epidemiology of pneumococcal disease, presents the latest surveillance data from Central and Eastern Europe, and discusses any similarities and differences in these data as well the potential implications for vaccination policies in the region.

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“…Ülkemizde konjuge pnömokok aşılarının ulusal aşılama programında uygulanmaya başlamasından önce yapılan çeşitli çalışmalarda, en sık izole edilen serotipler 1, 3, 5, 6A, 6B, 8, 9, 19A, 19F ve 23 olarak tespit edilmiştir 13,14 . Perçin ve arkadaşlarının 15 S.pneumoniae serotip 1, sıklıkla lober pnömoni ve parapnömonik ampiyemli olgulardan izole edilen invazif bir suştur 1,7 .…”

Section: Discussionunclassified

Invasive Pneumococcal Disease in Two Non-Vaccinated Pediatric Cases: Pleural Empyema and Bacteremia

Gülhan²,

Tezer³

et al. 2015

Mikrobiyol Bul

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ÖZGram-pozitif bir diplokok olan Streptococcus pneumoniae bakteriyemi, sepsis ve menenjit gibi ağır seyirli enfeksiyonlar ile seyreden invazif pnömokokal hastalıklar (İPH)'ın etkenidir. S.pneumoniae ve İPH'nin tüm dünyada önemli bir hastalık yükü oluşturması, ciddi mortalite ve morbiditeler ile seyretmesi ve aşı ile önlenebilir hastalık grubunda yer alması nedeniyle, aşı çalışmalarının odağında yer almaktadır. S.pneumoniae'nın 90'dan fazla tanımlanmış serotipi varken, İPH etkeni olarak belirli serotipler saptanmaktadır. Komorbid ve kronik hastalığı olanlar, < 2 yaş veya > 65 yaş bireyler, primer ya da sekonder immün yetmezliği olanlar İPH açısından artmış risk altındadırlar. Günümüzde pnömokoklar için 23 bileşenli polisakkarit aşı ile birlikte 7, 10 ve 13 bileşenli konjuge pnömokok aşıları (KPA) mevcuttur. Serotipten bağımsız koruma sağlayacak protein bazlı aşılar ile 15 bileşenli konjuge pnömokok aşısının faz çalış-maları halen devam etmektedir. Türkiye'de Kasım 2008'de KPA-7 ve Nisan 2011'de KPA-13 ulusal aşı takviminde uygulamaya girmiştir. Burada sunulan ilk olgu, daha önce pnömokok aşısı yapılmamış, altta yatan herhangi bir risk faktörü olmayan ve S.pneumoniae serotip 1'e bağlı pnömoni ve plevral ampiyem Geliş Tarihi

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Serotypes of Streptococcus pneumoniae Isolates from Children with Invasive Pneumococcal Disease in Turkey: Baseline Evaluation of the Introduction of the Pneumococcal Conjugate Vaccine Nationwide

Cited by 16 publications

References 23 publications

Serotype distribution and antimicrobial resistance of invasiveStreptococcus pneumoniaeisolates in Bulgaria before the introduction of pneumococcal conjugate vaccine

Serotype distribution and antimicrobial resistance of invasiveStreptococcus pneumoniaeisolates in Bulgaria before the introduction of pneumococcal conjugate vaccine

Surveillance of pneumococcal diseases in Central and Eastern Europe

Invasive Pneumococcal Disease in Two Non-Vaccinated Pediatric Cases: Pleural Empyema and Bacteremia

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