Serpin A12 (Vaspin) as a Serine Protease Inhibitor

Maghsoudi, Armin Salek; Hassani, Shokoufeh; Mirnia, Kayvan; Abdollahi, Mohammad

doi:10.1007/978-3-030-81303-1_7-1

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…For instance, a plasma serpin, Homo sapiens serpinA1, has been found to bind with proteins such as apolipoprotein and glucose-regulated proteins to maintain metabolic homeostasis, and a deficiency in serpinA1 can result in a series of metabolic diseases such as atheroma and diabetes mellitus ( Mashiba et al 2001 ; Pagetta et al 2003 ; Finotti and Pagetta 2004 ; O’Brien et al 2020 , 2022 ; Rabekova et al 2021 ). Moreover, Homo sapiens serpinA12 has been proven to regulate blood glucose metabolism levels by inhibiting human kallikrein 7, which cleaves human insulin, via a classical serpin mechanism ( Heiker et al 2013 ; Salek Maghsoudi et al 2022 ). Gene duplication is an important process in the origin of new traits, providing the original genetic material for evolution and various biological functions of offspring ( Pottier et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis

Wu,

Yuan,

et al. 2023

Molecular Biology and Evolution

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Parasitoids introduce various virulence factors when parasitism occurs, and some taxa generate teratocytes to manipulate the host immune system and metabolic homeostasis for the survival and development of their progeny. Host-parasitoid interactions are extremely diverse and complex, yet the evolutionary dynamics are still poorly understood. A category of serpin genes, named CvT-serpins, was discovered to be specifically expressed and secreted by the teratocytes of Cotesia vestalis, an endoparasitoid of the diamondback moth Plutella xylostella. Genomic and phylogenetic analysis indicated that the C. vestalis serpin genes are duplicated and most of them are clustered into 1 monophyletic clade. Intense positive selection was detected at the residues around the P1–P1′ cleavage sites of the Cv-serpin reactive center loop domain. Functional analyses revealed that, in addition to the conserved function of melanization inhibition (CvT-serpins 1, 16, 18, and 21), CvT-serpins exhibited novel functions, i.e. bacteriostasis (CvT-serpins 3 and 5) and nutrient metabolism regulation (CvT-serpins 8 and 10). When the host-parasitoid system is challenged with foreign bacteria, CvT-serpins act as an immune regulator to reprogram the host immune system through sustained inhibition of host melanization while simultaneously functioning as immune effectors to compensate for this suppression. In addition, we provided evidence that CvT-serpin8 and 10 participate in the regulation of host trehalose and lipid levels by affecting genes involved in these metabolic pathways. These findings illustrate an exquisite tactic by which parasitoids win out in the parasite–host evolutionary arms race by manipulating host immune and nutrition homeostasis via adaptive gene evolution and neofunctionalization.

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Section: Introductionmentioning

confidence: 99%

Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis

Wu,

Yuan,

et al. 2023

Molecular Biology and Evolution

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Analysis of the management and therapeutic performance of diabetes mellitus employing special target

Sun,

Lin

2023

World J Diabetes

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Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantly by hyperglycemia. The most common causes contributing to the pathophysiology of diabetes are insufficient insulin secretion, resistance to insulin’s tissue-acting effects, or a combination of both. Over the last 30 years, the global prevalence of diabetes increased from 4% to 6.4%. If no better treatment or cure is found, this amount might climb to 430 million in the coming years. The major factors of the disease’s deterioration include age, obesity, and a sedentary lifestyle. Finding new therapies to manage diabetes safely and effectively without jeopardizing patient compliance has always been essential. Among the medications available to manage DM on this journey are glucagon-like peptide-1 agonists, thiazolidinediones, sulphonyl urease, glinides, biguanides, and insulin-targeting receptors discovered more than 10 years ago. Despite the extensive preliminary studies, a few clinical observations suggest this process is still in its early stages. The present review focuses on targets that contribute to insulin regulation and may be employed as targets in treating diabetes since they may be more efficient and secure than current and traditional treatments.

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Serpin A12 (Vaspin) as a Serine Protease Inhibitor

Cited by 2 publications

References 83 publications

Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis

Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis

Analysis of the management and therapeutic performance of diabetes mellitus employing special target

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