Serrated pathway: a paradigm shift in CRC prevention

Dekker, Evelien; IJspeert, Joep E. G.

doi:10.1136/gutjnl-2017-314290

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…As SSLs have been established as precursors of colorectal cancer via the serrated neoplasia pathway, endoscopists should be trained to recognize and resect SSLs during colonoscopy. [24][25][26] In this study, the WASP classification showed a superior performance in reaching the PIVI thresholds with the incorporation of the optical diagnosis of SSLs. Using WASP classification showed a significant overall increase in the optical diagnosis of SSLs over time but a relatively lower sensitivity and longer learning curves compared with ADs (Supplementary Table 3).…”

Section: Discussionmentioning

confidence: 63%

Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program

Bae

Lee

Kang

et al. 2019

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 63%

Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program

Bae

Lee

Kang

et al. 2019

Clinical Gastroenterology and Hepatology

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“…Serrated lesions play a crucial role in the carcinogenesis of the colon 31 32. The risk of CRC in patients with serrated polyps is strongly associated with the size of the polyps.…”

Section: Discussionmentioning

confidence: 99%

Low detection rate of advanced neoplasia within 5 years after polypectomy of small serrated adenoma

Jin

Cao

Shah

et al. 2019

Postgraduate Medical Journal

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AimPatients with small serrated adenomas (SAs) (<10 mm) often undergo surveillance colonoscopy before the routine recommended time. We aimed to determine the appropriate surveillance intervals following polypectomy of small SAs for symptomatic patients.MethodWe retrospectively reviewed the data of 638 patients, including 122 cases and 516 controls. Subjects in the case group had small SAs at baseline colonoscopy, including sessile SA/polyps and traditional SAs, while subjects in the control group had negative findings. All patients underwent at least one surveillance colonoscopy during the following 5 years.ResultsThere was no significant difference in the incidence rate of advanced neoplasia between the two groups over a 5-year duration (3.6% vs 2.6%, p=0.455). Moreover, both groups also showed a low prevalence of SA formation over 1–5 years (3.6% vs 1.0%, p=0.145). Patients with baseline SA tended to undergo the first surveillance colonoscopy earlier than those without adenoma (≤1 year vs 1 to ≤3 years). Seventy-one (11.1%) of the total included subjects underwent inadequate initial colonoscopy, and 30 (42.3%) underwent early surveillance of adenoma formation within 1 year. Patients with a family history of colorectal cancer (OR 4.69, 95% CI 1.48 to 14.71, p=0.017) or inadequate baseline colonoscopy (OR 3.17, 95% CI 1.202 to 8.409, p=0.035) were at a higher risk of metachronous adenoma formation during the surveillance period.ConclusionPatients with small SAs at baseline gain little benefit from follow-up of colonoscopy within 5 years after complete polypectomy.

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“…The targeted treatment of tumors has attracted increasing attention and several targeted drugs are extensively used in the clinic (4) with demonstrated effectiveness (5). An increased understanding of the molecular mechanism underlying the pathogenesis of CRC may aid with the identification of effective therapeutic targets and novel biomarkers for the risk assessment and early diagnosis of CRC (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4

et al. 2020

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Recent studies have revealed that microRNAs (miRs) are involved in the pathogenesis of colorectal cancer (CRC); however, the roles of miR-590-5p in CRC are not completely understood. Therefore, the present study investigated the expression of miR-590-5p and programmed cell death 4 (PDCD4) in CRC tissues and healthy adjacent tissues via reverse transcription-quantitative PCR. Furthermore, human CRC cells were cultured in vitro and transfected with miR-590-5p inhibitor. CRC cell viability, migration and invasion were evaluated by conducting MTT, wound healing and Transwell assays, respectively. Additionally, the relative expression of PDCD4 and phosphorylated-Smad2/3 was analyzed via western blotting. miR-590-5p was significantly upregulated and PDCD4 was significantly downregulated in CRC tissues compared with healthy adjacent tissues. Moreover, the results indicated that miR-590-5p knockdown inhibited cell viability and migration by altering the expression of PDCD4, transforming growth factor-β and phosphorylated-Smad2/3. PDCD4 was identified as a direct target of miR-590-5p. In conclusion, the results of the present study suggested that miR-590-5p may regulate CRC cell viability and migration, indicating that miR-590-5p may serve as a potential therapeutic target for CRC.

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Serrated pathway: a paradigm shift in CRC prevention

Cited by 6 publications

References 12 publications

Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program

Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program

Low detection rate of advanced neoplasia within 5 years after polypectomy of small serrated adenoma

miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4

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