Serratia marcescens Endocarditis

Elkattawy, Sherif; Mohammadian, Mahsa; Williams, Neil; Mowafy, Ahmed; Ayad, Sarah; Noori, Muhammad Atif Masood; Younes, Islam; Singh, Kerry S; Millman, Arthur

doi:10.7759/cureus.17346

Cited by 4 publications

(7 citation statements)

References 16 publications

(27 reference statements)

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“…A endocardite por S.marcescens frequentemente afeta as valvas do lado esquerdo, causando destruição significativa da valva, embolização séptica e altas taxas de mortalidade sem intervenção cirúrgica. 6 , 7 , 9 , 10 A terapia antimicrobiana apropriada é incerta devido à considerável resistência aos antibióticos, mas os regimes aceitos geralmente envolvem uma combinação de um betalactâmico e um aminoglicosídeo. 4 , 5 , 8 A cirurgia é frequentemente negada a pacientes com câncer, mal orientados pelo conceito de carga considerável de comorbidades e a terapia antitumoral geralmente é suspensa.…”

Section: Discussionunclassified

“…S. marcescens endocarditis often affects left-sided valves, causing significant valve destruction, septic embolization, and high mortality rates without surgical intervention. 6 , 7 , 9 , 10 Appropriate antimicrobial therapy is uncertain due to considerable antibiotic resistance but accepted regimens typically involve a combination of a beta-lactam and an aminoglycoside. 4 , 5 , 8 Surgery is often denied to cancer patients misguided by the concept of considerable comorbidity burden, and antitumoral therapy is usually withdrawn.…”

Section: Discussionmentioning

confidence: 99%

“…Embora a bacteremia causada por S. marcescens , um bacilo gram-negativo não-HACEK, não seja incomum, sua associação com EI é bastante rara. 6 , 7 …”

Section: Introductionunclassified

“…Although bacteremia caused by S. marcescens , a non-HACEK gram-negative bacillus, is not uncommon, its association with IE is quite rare. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

“…Embora a bacteremia causada por S. marcescens, um bacilo gram-negativo não-HACEK, não seja incomum, sua associação com EI é bastante rara. 6,7 Relato de caso Paciente do sexo masculino, 51 anos, com histórico de hipertensão, tabagismo e obesidade, foi submetido à penectomia parcial por carcinoma espinocelular ulcerado do pênis em janeiro de 2020. Em março de 2021, uma tomografia computadorizada (TC) torácico-abdominopélvica revelou uma massa na esquerda da região inguinal com linfonodos aumentados ilioinguinais e para-aórticos.…”

Section: Introductionunclassified

See 4 more Smart Citations

Endocardite da Válvula Mitral – Uma Causa Rara num Doente com Neoplasia

Duarte,

Machado,

Oliveira

et al. 2023

Arquivos Brasileiros De Cardiologia

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Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

“…Embora a bacteremia causada por S. marcescens , um bacilo gram-negativo não-HACEK, não seja incomum, sua associação com EI é bastante rara. 6 , 7 …”

Section: Introductionunclassified

“…Although bacteremia caused by S. marcescens , a non-HACEK gram-negative bacillus, is not uncommon, its association with IE is quite rare. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionunclassified

See 3 more Smart Citations

Endocardite da Válvula Mitral – Uma Causa Rara num Doente com Neoplasia

Duarte,

Machado,

Oliveira

et al. 2023

Arquivos Brasileiros De Cardiologia

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Serratia marcescens: microbiological characterization, resistance properties, virulence and clinical relevance

Sadeeva

Novikova

Alyabieva

et al. 2023

RPJ

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Serratia marcescens (SM) is among the most relevant pathogens of opportunistic infections. This review contains an analysis of the literature data on the importance of serrations in medical practice. Molecular genetic predictors of virulence and antibiotic resistance of this pathogen were analyzed in detail. The review discusses the main methods of typing SM. Various local and generalized s of infections caused by SM are described.

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A Rare Presentation of Infective Endocarditis Due to Serratia marcescens

Shah¹,

Patel²,

Rashid³

et al. 2022

Cureus

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Serratia marcescens is an opportunistic organism that can commonly cause respiratory tract infections in immunocompromised individuals. It has also been shown to cause urinary tract infections and soft tissue infections. It has several virulence factors including fimbriae-like adhesions that allow for surface attachment and biofilm formation to increase the likelihood of infections in humans. However, it has rarely been shown to cause infective endocarditis but has an increased mortality compared to the usual microbial agents associated with it (Staphylococcus and Streptococcus). Therefore, a high index of suspicion is necessary to accurately diagnose and treat patients at risk. Most published cases of S. marcescens endocarditis show that almost all described patients had chronic medical conditions or cardiovascular abnormalities. Furthermore, treatment has become difficult as S. marcescens has been shown to exhibit antibacterial resistance with beta-lactamase production.Here, we present a complicated case of S. marcescens pneumonia and infective endocarditis with a good prognosis. Our patient had a rapid onset of complications (i.e. including joint infections, splenic abscesses, myositis, and septic arthritis), despite the initial benign presentation concerning for pneumonia. However, the patient had a favorable outcome due to the prompt work-up and treatment that was initiated. Therefore, S. marcescens bacteremia in a patient with risk factors should prompt further investigation with a thorough evaluation of source followed by immediate management. This case highlights the fastidious nature of S. marcescens. Further investigation needs to be done to elucidate the pathogenesis of the organism that can serve as a target for future therapeutic intervention.

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Serratia marcescens Endocarditis

Cited by 4 publications

References 16 publications

Endocardite da Válvula Mitral – Uma Causa Rara num Doente com Neoplasia

Endocardite da Válvula Mitral – Uma Causa Rara num Doente com Neoplasia

Serratia marcescens: microbiological characterization, resistance properties, virulence and clinical relevance

A Rare Presentation of Infective Endocarditis Due to Serratia marcescens

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