SERS Immunosensors for Cancer Markers Detection

Geka, Georgia; Kanioura, Anastasia; Likodimos, V.; Gardelis, S.; Papanikolaou, N.; Kakabakos, Sotirios; Petrou, Panagiota

doi:10.3390/ma16103733

Cited by 11 publications

(10 citation statements)

References 151 publications

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“…Whereby, the combined usage of various NMs on metal films (such as Au NP and Ag NP), magnetic NP (like quantum dots and carbon nanotubes), and nanomaterials such as photonic crystals (PhC), and graphene materials offer excellent biocompatibility, unique conductivity, and optical properties in SPR platforms [87,99,105,[115][116][117]. Moreover, metal films have been employed to enhance the local electromagnetic field and increase the efficiency of Raman scattering by several orders of magnitude, leading to SERS [118,119].…”

Section: Surface Plasmon Resonance (Spr) Optical Biosensingmentioning

confidence: 99%

“…Raman spectroscopy is a versatile, label-free method with extensive use in cancer diagnoses and material analysis [119]. This technique has been extensively used in cancer diagnosis and analysis [116].…”

Section: Lspr Co-enhanced Raman Scatteringmentioning

confidence: 99%

“…On the other hand, the combination of Raman spectroscopy and SPR techniques enhances analytical performance and provides valuable chemical insights, improving our understanding of surface interactions and processes [110]. While SERS overcomes limitations in traditional Raman spectroscopy such as signal intensity and specificity, it has its own drawbacks including reproducibility issues and the potential impact of metalmolecule binding on result consistency and reliability [114,116,119]. In a study by Tun C et al, CA125 detection was achieved using LSPR-SERS, but the interaction between Ag nanoparticles and the antigen was hindered due to the antigen's distant position from the antibody [120].…”

Section: Challenges and Future Preceptive In Developing New Spr-based...mentioning

confidence: 99%

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Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Kumar,

Kampan,

Abd Aziz

et al. 2023

Cancers

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Epithelial Ovarian Cancer (EOC) is a leading cause of cancer-related deaths among women, mainly due to a lack of early detection and screening methods. Advanced immunoassay techniques, such as Luminex and proximity extension assay (PEA) technology, show promise in improving EOC detection by utilizing highly sensitive and specific multiplex panels to detect multiple combinations of biomarkers. However, these advanced immunoassay techniques have certain limitations, especially in validating the performance characteristics such as specificity, sensitivity, limit of detection (LOD), and dynamic range for each EOC biomarker within the panel. Implementing multiplexing in point-of-care (POC) biosensors can enhance EOC biomarker detection, with Surface Plasmon Resonance (SPR) being a versatile option among optical biosensors. There is no study on multiplex SPR biosensors specifically tailored for diagnosing EOC. Recent studies have shown promising results in the single detection of EOC biomarkers using SPR, with LOD for cancer antigen 125 (CA125) at 0.01 U/mL−1 and human epididymis protein 4 (HE4) at 1pM. This study proposes a potential roadmap for scientists and engineers in academia and industry to develop a cost effective yet highly efficient SPR biosensor platform for detecting EOC.

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Section: Surface Plasmon Resonance (Spr) Optical Biosensingmentioning

confidence: 99%

Section: Lspr Co-enhanced Raman Scatteringmentioning

confidence: 99%

Section: Challenges and Future Preceptive In Developing New Spr-based...mentioning

confidence: 99%

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Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Kumar,

Kampan,

Abd Aziz

et al. 2023

Cancers

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“…The molecules of amino acid play a crucial role in the normal functioning of various physiological process of human body, making the detection of amino acid concentrations an essential prerequisite for clinical diagnosis, drug development, and gene therapy [1][2][3][4][5]. Conventional detection methods for mainstream biochemical samples involve marked the samples [6][7][8][9]. This labeling approach is complex, time-consuming, and can damage the tested samples.…”

Section: Introductionmentioning

confidence: 99%

Terahertz sensing of L-Valine and L- Phenylalanine solutions

Shu,

Zhou,

Hao

et al. 2024

Preprint

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An asymmetric folded double-open ring of metasurface sensor based on the Fano resonance has been designed, with its resonant frequency matching the absorption peak of L-Valine at 1.7 THz. A mixture of water and glycerol in a volume ratio of 2:8 was proposed as a solvent to reduce the absorption of terahertz waves by water. A sample chamber with a controlled liquid thickness of (15 μm) was fabricated. A vertical incidence of terahertz time-domain spectrometer (THz-TDS) was constructed to allow solutions to be placed horizontally, and two different concentrations of amino acid solutions were subsequently measured. As the concentration of L-Valine solution varied from 0 to 20mM, the resonance peak of sensor shifted from 1.39 THz to 1.58 THz, demonstrating a concentration sensitivity of 9.98GHz/mM. The resonance peak shift in the L-Phenylalanine solution was not pronounced. It is speculated that the coupling enhancement between the solute absorption peak and the sensor resonance peak in the solution leads to an increased frequency shift, highlighting the distinctive sensing detection.

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“…The current mainstream biochemical sample testing on the market requires labeling of the samples being tested [ 6 , 7 , 8 , 9 ]. This labeling method is complex and time-consuming and can damage the tested samples.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Sensing of L-Valine and L-Phenylalanine Solutions

Shu,

Zhou,

Hao

et al. 2024

Sensors

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To detect and differentiate two essential amino acids (L-Valine and L-Phenylalanine) in the human body, a novel asymmetrically folded dual-aperture metal ring terahertz metasurface sensor was designed. A solvent mixture of water and glycerol with a volume ratio of 2:8 was proposed to reduce the absorption of terahertz waves by reducing the water content. A sample chamber with a controlled liquid thickness of 15 μm was fabricated. And a terahertz time-domain spectroscopy (THz-TDS) system, which is capable of horizontally positioning the samples, was assembled. The results of the sensing test revealed that as the concentration of valine solution varied from 0 to 20 mmol/L, the sensing resonance peak shifted from 1.39 THz to 1.58 THz with a concentration sensitivity of 9.98 GHz/mmol∗L−1. The resonance peak shift phenomenon in phenylalanine solution was less apparent. It is assumed that the coupling enhancement between the absorption peak position of solutes in the solution and the sensing peak position amplified the terahertz localized electric field resonance, which resulted in the increase in frequency shift. Therefore, it could be shown that the sensor has capabilities in performing the marker sensing detection of L-Valine.

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SERS Immunosensors for Cancer Markers Detection

Cited by 11 publications

References 151 publications

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers

Terahertz sensing of L-Valine and L- Phenylalanine solutions

Terahertz Sensing of L-Valine and L-Phenylalanine Solutions

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