Sertoli cell-derived extracellular vesicles traverse the blood-testis barrier and deliver miR-24-3p inhibitor into germ cells improving sperm mobility

Chen, Yabing; Xu, Dihui; Ma, Yuhan; Chen, Peilin; Hu, Jianhang; Chen, Deyan; Yu, Wen; Han, Xiaodong

doi:10.1016/j.jconrel.2023.08.031

Journal of Controlled Release

2023

DOI: 10.1016/j.jconrel.2023.08.031

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Sertoli cell-derived extracellular vesicles traverse the blood-testis barrier and deliver miR-24-3p inhibitor into germ cells improving sperm mobility

Yabing Chen,

Dihui Xu,

Yuhan Ma

et al.

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2024

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Cited by 3 publications

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Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility

Doghish,

Elsakka,

Moustafa

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility

Doghish,

Elsakka,

Moustafa

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Microcystin-LR prenatal exposure induces coronary heart disease through macrophage polarization imbalance mediated by trophoblast-derived extracellular vesicles

Guo,

Li,

Choi

et al. 2024

Science of The Total Environment

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Engineered nanoparticles potentials in male reproduction

Zhao,

Fan,

Jing

et al. 2024

Andrology

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BackgroundThe escalating prevalence of fertility problems in the aging population necessitates a comprehensive exploration of contributing factors, extending beyond environmental concerns, work‐related stress, and unhealthy lifestyles. Among these, the rising incidence of testicular disorders emerges as a pivotal determinant of fertility issues. Current treatment challenges are underscored by the limitations of high‐dose and frequent drug administration, coupled with substantial side effects and irreversible trauma inflicted by surgical interventions on testicular tissue.Material and methodsThe formidable barrier posed by the blood–testis barrier compounds the complexities of treating testicular diseases, presenting a significant therapeutic obstacle. The advent of nanocarriers, with their distinctive attributes, holds promise in overcoming this impediment. These nanocarriers exhibit exceptional biocompatibility, and membrane penetration capabilities, and can strategically target the blood–testis barrier through surface ligand modification, thereby augmenting drug bioavailability and enhancing therapeutic efficacy.Results and discussionThis review concentrates on the transformative potential of nanocarriers in the delivery of therapeutic agents to testicular tissue. By summarizing key applications, we illuminate the strides made in utilizing nanocarriers as a novel avenue to effectively treat testicular diseases.ConclusionsNanocarriers are critical in delivering therapeutic agents to testicular tissue.

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Sertoli cell-derived extracellular vesicles traverse the blood-testis barrier and deliver miR-24-3p inhibitor into germ cells improving sperm mobility

Cited by 3 publications

References 53 publications

Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility

Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility

Microcystin-LR prenatal exposure induces coronary heart disease through macrophage polarization imbalance mediated by trophoblast-derived extracellular vesicles

Engineered nanoparticles potentials in male reproduction

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