Serum 25 Hydroxy Vitamin D Levels In Adult Asthmatic Patients

Shaaban, Mostafa M.; Hashem, Manal M.

doi:10.21608/ejhm.2012.16229

Cited by 7 publications

(1 citation statement)

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“…Group (A) Shaaban and Hashem (9) investigated serum vitamin D levels in 75 adults with asthma and 75 adult healthy controls and demonstrated that, Vitamin D deficiency was observed in 78.66% asthmatic patients whereas 85% of healthy control subjects expressed sufficient levels thus results correlating with this study.…”

Section: Asthma In Between Attacksupporting

confidence: 73%

Vitamin D Deficiency and Its Effect on Severity of Asthma in Adult Patients

Solanki¹,

Suthar²,

Chaudhary³

et al. 2020

IJABMS

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AIM: This study is aimed to assess vitamin D status in asthmatic patients and to assess the relationship between vitamin D level and asthma severity. INTRODUCTION:Asthma is heterogeneous disease, usually characterized by variable airflow obstruction and bronchial hyper-responsiveness. The world health organization stated that approximately 300 million people have asthma. Recently the effects of vitamin D appear to have regulatory effect on every part of immune system, vitamin D deficiency being linked to an array of immunologically based disease focusing on asthma. METHOD:The present study included 50 patients diagnosed as bronchial asthma. The asthmatic patient group was divided into group A, asthma in between attack and group B, exacerbated asthma, that was again divided in subgroup (I), (II), and (III) mild , moderate and severe exacerbated asthma according to symptoms and FEV1. Serum 25 hydroxy vitamin D3 level in all groups was measured by radio immunoassay method and compared between these groups. RESULT:This study shows statistically significant correlation between vitamin D level and severity of asthma. The mean levels of serum 25 hydroxy vitamin D3 in asthmatic patients are: Group A-28.24 ± 1.35 ng/ml, mild persistent-22.6 ± 11.5 ng/ml, moderate persistent -18.33 ± 1.31 ng/ml, and severe persistent -10.45 ± 1.84 ng/ml. P value is <0.01, which is highly significant. CONCLUSION:Lower level of vitamin D is associated with higher severity of asthma. Keyword: VITAMIN D DEFICIENCY, SEVERITY OF ASTHMA, ADULT ATIENTS INTRODUCTION:Asthma is heterogeneous disease, usually characterized variable airflow obstruction, chronic airway inflammation and bronchial hyper-responsiveness (1). Until recently bronchospasm was considered cardinal feature of asthma but now in addition to bronchospasm, airway inflammation is recognized as an essential component of the disease. Asthma prevalence is rising in both the developed and developing world with >3 million people affected worldwide (2,3) . Vitamin D is fat soluble nutrient and a secosteroid hormone produced endogenously in the skin from sun exposure or obtained from foods that naturally contain vitamin D including cod liver oil. Vitamin D deficiency is diagnosed by the concentration of blood S.25 (OH) D3 (vitamin D) level, the primary circulatory form of vitamin D and then 1, 25(OH) D3. Low serum level of vitamin D has been linked to increased risk of asthma exacerbation in children and adults.

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Section: Asthma In Between Attacksupporting

confidence: 73%

Vitamin D Deficiency and Its Effect on Severity of Asthma in Adult Patients

Solanki¹,

Suthar²,

Chaudhary³

et al. 2020

IJABMS

View full text Add to dashboard Cite

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Assessment of Serum Vitamin D in Patients with Bronchial Asthma

Aaty

Aziz

Habashy

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Asthma is one of the most common chronic diseases worldwide and has been increasing in prevalence over the last few decades; its exact cause remains unknown and likely has its origin in complex interactions among multiple genetic and environmental factors. The World Health Organization (WHO) stated that approximately 300 million people have asthma. Recently the effects of vitamin D as a hormone have gained attention. Vitamin D appears to have regulatory effects on every part of the immune system, vitamin D deficiency being linked to an array of immunologically based diseases focusing on asthma. So the assessment of serum vitamin D in patients with bronchial asthma is useful.Objective: The aim of this study is to assess the level of serum vitamin D in patients with bronchial asthma.Methods: The present study, included 50 subjects, 40 patients diagnosed as bronchial asthma and 10 healthy volunteers. The asthmatic patient group was divided into group (A) asthma in between attack and group (B) exacerbated asthma, that was divided into subgroups (I), (II) and (III) mild, moderate and severe exacerbated asthma, respectively according to severity of symptoms and FEV1. Results: Serum vitamin D level was highly significantly lower in the asthmatic patient group compared to the control subject group and lowest serum 25 hydroxy(OH) vitamin D value in the severely exacerbated asthma group. There was a positive correlation between decreased serum 25 (OH)D levels and decreased FEV1.Conclusions: Vitamin D deficiency was highly prevalent in asthmatic patients, there was a strong correlation between asthma severity and 25(OH) vitamin D concentrations and there was a direct * Corresponding author. Address: and a positive significant correlation between vitamin D levels and pulmonary function tests in asthmatic patients, so the measurement of serum vitamin D levels in patients with bronchial asthma is very useful.

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