Serum 25 Hydroxy Vitamin D Insufficiency Associated with Bronchial Asthma in Lucknow, India

Awasthi, Sanjay; Kate, Vikram

doi:10.1007/s12098-013-1310-6

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…This in agreement with [14], [23], [24] and15 study which showed statistically significant correlation between asthma control and vitamin D status [p value < 0.001].…”

Section: Discussionsupporting

confidence: 93%

“…The study showed the correlation between vitamin [D] level and asthma control in asthmatic children. our study was crosssectional study conducted on 60 asthmatic child aged 4-15 years old 80%of them were vitamin D deficient [ levels <20 ng/ml] and 20% were in insufficient range with levels [20][21][22][23][24][25][26][27][28][29][30] Our study reveiled statistically significant difference between serum vitamin D level and associated atopic conditions.…”

Section: Discussionmentioning

confidence: 98%

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Correlation between Serum vitamin D and Asthma Control in Asthmatic Children

Arafa

Ismail

Sobeih

et al. 2019

Benha Journal of Applied Sciences

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Asthma is a chronic ,inflammatory ,respiratory tract disease accompanied by hypersensitivity of airways, recurring wheezing episodes, respiratory distress and coughing. The aim of this study was to estimate vitamin D level and specific IgE level in asthmatic children who were on controller medication and correlated their serum level with asthma control . Our results clarified that The serum vitamin[D] levels were closely related to asthma attacks. As,There were statistically significant positive correlations between serum vitamin D level and asthma control in asthmatic children. There were no significant difference in mean serum vitamin [D] between male and female and according to parent consanguinity while shows significant difference regarding order of sibling. there were no significant difference in mean serum vitamin [D] according to family history of atopy and passive smoking, while shows significant difference regarding family history of asthma, associated allergic condition, day time symptoms, night time awakness, degree of asthma control, recurrent hospital admission , interference with activity and frequency of exacerbation and influenza &pneumococcal vaccination. significant difference in mean serum vitamin [D] according to food born allergen: apple ,banana ,casein ,cow milk ,egg white, peanut while regarding airborne allergen shows nonsignificant difference with ,Der.pteronyssinus, Der.farinae ,Cockroach and Honey bee venom and Aspergillus fumigatus . Common wasp venom , Altearia alternate, Honey bee venum,Birch ,Candida albican ,Dog epith. and cat epithelium demonstrated significant difference. From our results, it would be concluded that there was a significant correlation between vitamin [D] level and asthma control in asthmatic children .

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“…This in agreement with [14], [23], [24] and15 study which showed statistically significant correlation between asthma control and vitamin D status [p value < 0.001].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Correlation between Serum vitamin D and Asthma Control in Asthmatic Children

Arafa

Ismail

Sobeih

et al. 2019

Benha Journal of Applied Sciences

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“…Ten studies was selected to explore the association between vitamin D and FEV1% (r = 0.27, 95% CI = 0.22 to 0.33, p < 0.001; I2 = 93%, P < 0.001). Three studies [32, 42, 48] were regarded as homogeneous after a sensitivity analysis and were eliminated from the pooled result (r = 0.19, 95% CI = 0.13 to 0.26, p < 0.001; I2 = 42%, P = 0.11) (Fig. 3b).…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of vitamin D and lung function in patients with asthma

Liu

Dong²,

Yin

et al. 2019

Respir Res

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Background There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation between serum vitamin D and lung function in asthma patients. Methods Major databases, including OVID, MEDLINE, Web of Science and PUBMED, were searched until 10th October 2018. All published observational studies related to vitamin D and asthma were extracted. All meta-analyses were performed using Review Manager 5.3.5. Results This quantitative synthesis found that asthma patients with low vitamin D levels had lower forced expiratory volume In 1 s (FEV1) (mean difference (MD) = − 0.1, 95% CI = − 0.11 to − 0.08,p < 0.01;I2 = 49%, p = 0.12) and FEV1% (MD = − 10.02, 95% CI = − 11 to − 9.04, p < 0.01; I2 = 0%, p = 0.82) than those with sufficient vitamin D levels. A positive relation was found between vitamin D and FEV1 (r = 0.12, 95% CI = 0.04 to 0.2, p = 0.003; I2 = 59%,p = 0.01), FEV1% (r = 0.19, 95% CI = 0.13 to 0.26, p < 0.001; I2 = 42%, p = 0.11), forced vital capacity (FVC) (r = 0.17, 95% CI = 0.00 to 0.34, p = 0.05; I2 = 60%, p = 0.04), FEV1/FVC (r = 0.4, 95% CI = 0.3 to 0.51, p < 0.001; I2 = 48%, p = 0.07), and the asthma control test (ACT) (r = 0.33, 95% CI = 0.2 to 0.47, p < 0.001; I2 = 0%, p = 0.7). Subgroup analysis indicated that the positive correlation between vitamin D and lung function remained significant in both children and adults. Conclusions Our meta-analysis suggested that serum vitamin D levels may be positively correlated with lung function in asthma patients. Future comprehensive studies are required to confirm these relations and to elucidate potential mechanisms.

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“…[17] Likewise, an Indian study done in asthmatic children aged 1–15 years has shown between serum 25-hydroxy Vitamin D (25(OH)D) insufficiency and level of asthma control. [18]…”

Section: Introductionmentioning

confidence: 99%

Effects of genetic polymorphisms in Vitamin D metabolic pathway on Vitamin D level and asthma control in South Indian patients with bronchial asthma

et al. 2019

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Objectives:The study was designed to evaluate the single-nucleotide polymorphisms (SNPs) of genes involved in Vitamin D actions (rs2228570) and metabolic pathways (rs2248137 and rs10766197) and their associations with serum 25-hydroxy Vitamin D (25(OH)D) level and asthma control in South Indian patients with bronchial asthma.Materials and Methods:One hundred and two patients of South Indian origin with bronchial asthma either naive to inhaled corticosteroids (ICSs) or not receiving ICS for ≥1 month were included and were treated with ICS (beclomethasone 200 μg twice daily) for 8 weeks. One hundred and one unrelated healthy South Indians were used as controls. Pulmonary function test and fractional exhaled nitric oxide were used to assess asthma control. Serum 25(OH)D levels (chemiluminescence immunoassay) and SNPs in Vitamin D pathway (real-time polymerase chain reaction) were assessed. The associations of SNPs and serum 25(OH)D with asthma control was determined using linear regression. All analyses were performed using SPSS (version 19) and “SNPStats.” P < 0.05 was considered as statistically significant.Results:Vitamin D receptor (VDR) polymorphism (rs2228570) was found to be protective against asthma (P = 0.022), while there were no significant associations between the other two SNPs and asthma. Similarly, poor correlation and insignificant associations between the SNPs and serum 25(OH)D levels were observed in both cases and controls. There were also insignificant associations between the SNPs and asthma control.Conclusion:VDR polymorphism (rs2228570) was found to be protective against asthma in South Indians, while other genes involved in the metabolic pathway of Vitamin D did not show associations with asthma.

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Serum 25 Hydroxy Vitamin D Insufficiency Associated with Bronchial Asthma in Lucknow, India

Abstract: 25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.

Cited by 12 publications

References 25 publications

Correlation between Serum vitamin D and Asthma Control in Asthmatic Children

Correlation between Serum vitamin D and Asthma Control in Asthmatic Children

Meta-analysis of vitamin D and lung function in patients with asthma

Effects of genetic polymorphisms in Vitamin D metabolic pathway on Vitamin D level and asthma control in South Indian patients with bronchial asthma

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