Serum 25-Hydroxy Vitamin D levels in Type 2 Diabetes Mellitus-A Comparative study

Swamy, Mallikarjuna; Ganiger, Arati; Ds, Shankar; Ratna, Sanjeev

doi:10.5958/2394-6377.2016.00049.6

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the role of VD in pancreatic β-cell functions, which acts to enhance insulin secretion and conversion from proinsulin to insulin, VD might facilitate insulin action by simulating the insulin receptors expression and regulation of the calcium pool. [29] Therefore, VD must be considered in blood glucose homeostasis and thus diabetic complications. [30]…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency increases risk of nephropathy and cardiovascular diseases in Type 2 diabetes mellitus patients

et al. 2019

View full text Add to dashboard Cite

Background: Vitamin D (VD) deficiency is associated with insulin function and secretion. It is linked with diabetes mellitus (DM) progression, and complications were also recorded. Therefore, the current study aimed to investigate serum VD level in Type 2 DM (T2DM) patients and its association with diabetic nephropathy and cardiovascular diseases (CVD). Materials and Methods: In this cross-sectional study, 205 patients with Type 2 diabetes age ranged from 39 to 75 years old were enrolled. Serum VD, high-sensitivity C-reactive protein (hs-CRP), and hemoglobin A1c (HbA1c) were measured. In addition, urinary albumin:creatinine ratio (ACR) was estimated. Results: Patients with Type 2 diabetes had a 78.5% VD level <30 ng/m. ACR and hs-CRP levels were significantly increased in patients with diabetes with VD <30 ng/m ( P = 0.011 and P = 0.008, respectively). Female had significantly lower VD level than male P < 0.001. Patients exposed to sunlight had significantly higher VD level and lower hs-CRP levels compared with less-exposed, P value (0.001 and <0.001), respectively. Exercise significantly increased VD and decreased ACR levels in DM patients, P value (0.046 and 0.002), respectively. VD was positively associated with age ( r = 0.355 P = 0.040) and negatively correlate with BMI ( r = −0.502 P = 0.009), duration of disease ( r = −0.498 P = 0.003), ACR ( r = −0.384 P = 0.015), and HbA1c ( r = −0.327 P = 0.032). Conclusion: The evidence from this study suggest that patients with Type 2 diabetes with VD deficiency are at higher risk for developing CVD and nephropathy.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency increases risk of nephropathy and cardiovascular diseases in Type 2 diabetes mellitus patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As VD enhances pancreatic β-cell secretion of insulin and activation from proinsulin to insulin, it might help in insulin function by simulating the insulin receptors expression and control of the calcium level. 22 So, VD must be known for blood sugar homeostasis and hence complications of diabetes.…”

Section: S Nomentioning

confidence: 99%

Vitamin D Deficiency and its Association with Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross Sectional Study

Kumar

Atam

Kumar

et al. 2020

JoARM

View full text Add to dashboard Cite

Background: Vitamin D (VD) deficiency is linked to insulin activity and its release. It is associated with uncontrolled diabetes and more complications in diabetic patients. So, this study will prove importance of investigating serum VD level in Type 2 DM (T2DM) patients and its relation to complication of diabetic nephropathy. Materials and Methods: Total 1025 patients with Type 2 diabetes were enrolled in this study. Age limit was from 40 to 76 year. Investigations for serum VD, haemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (hs-CRP) and urinary Albumin: Creatinine Ratio (ACR) were done in each patient. Result: It was found that most of the patient (77.89%) were having VD<29.88 ng/m along with significantly higher ACR and hs-CRP levels in these patients (P=0.012 and P=0.007, respectively). VD was observed significantly lesser in females than males P < 0.001. Those patients who were exposed to sunrays had significantly more VD values and lesser hs-CRP values in comparison to less-exposed ones, P-value (0.001 and <0.001), respectively. Physical activity significantly raises VD and decreases ACR levels in diabetic patients, P-value (0.045 and 0.001), respectively. Except age (r=0.356 P=0.041) all other factors like BMI (r=−0.503 P=0.008), duration of disease (r=−0.489 P=0.004), ACR (r=−0.295 P=0.016) and HbA1c (r=−0.330 P=0.031) were negatively correlated with VD. Conclusion: This study concluded that Type 2 diabetes with VD deficiency are prone for the development of nephropathy.

show abstract

Serum 25-Hydroxy Vitamin D levels in Type 2 Diabetes Mellitus-A Comparative study

Cited by 2 publications

References 0 publications

Vitamin D deficiency increases risk of nephropathy and cardiovascular diseases in Type 2 diabetes mellitus patients

Vitamin D deficiency increases risk of nephropathy and cardiovascular diseases in Type 2 diabetes mellitus patients

Vitamin D Deficiency and its Association with Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross Sectional Study

Contact Info

Product

Resources

About