Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes

Arterial stiffness and 25-hydroxyvitamin D levels in chronic kidney disease patients

“…[13][14][15][16]30,31 Brachial-ankle PWV was found to be significantly lower in CKD patients with 25(OH)D deficiency. 15 It has been reported that flow-mediated dilatation as a marker of endothelial function was lower in vitamin D deficiency in patients with CKD, and improved with replacement of 25(OH)D. In addition, vitamin D supplementation significantly reduced biomarkers of endothelial dysfunction such as intracellular adhesion molecule (ICAM), vascular adhesion molecule (VCAM), endothelial leukocyte adhesion molecule (E-Selectin) and von Willebrand factor (vWF).…”

“…9,10,12 Previous studies have demonstrated the association between 25(OH)D deficiency and increased arterial stiffness in chronic diseases such as lupus, diabetes, hyperparathyroidism, and kidney disease. [13][14][15] Pulse wave velocity (PWV) and augmentation index normalized with 75/min heart rate (Alx@75) are considered to be gold standard index for arterial stiffness. 1,3,6 Al Mheid et al 16 demonstrated that 25(OH)D levels negatively correlated with PWV and Alx in healthy subjects, and reported that vitamin D deficiency increased arterial stiffness effecting by vascular dysfunction.…”

Serum 25-hydroxyvitamin D level is associated with aortic distensibility and left ventricle hypertrophy in newly diagnosed type 2 diabetes mellitus

“…10 Previous studies were reported that lower vitamin D is associated with increased arterial stiffness. 9 In diabetic patients, relationship between arterial stiffness and vitamin D level was reported in only one study. 9 However, in previous studies, AD was not investigated according to vitamin D levels.…”

“…Such relationship between vitamin D and DM is not surprising given that vitamin D deficiency has been associated with insulin resistance and impaired β-cell function. 8 Recently, Lee et al 9 reported that low 25-dihydroxy vitamin D level is significantly associated with increased arterial stiffness in patients with DM. Moreover, relationship between endothelial dysfunction and low vitamin D level was reported in patients with DM.…”

Relationship between 25-hydroxyvitamin D Level and Metabolic Control and Albumin Excretion Rate in Elderly Patients with Type 2 Diabetes Mellitus

“…Low 25(OH)D levels are common in patients with both Type 1 and Type 2 diabetes mellitus [21][22][23]. Similarly, Lee et al [24] showed that the mean concentration (±SD) of 25(OH)D in patients with type 2 DM was 11.2 (±6.1) ng/ml with a prevalence of Vitamin D deficiency of 85.9%. To our findings, 25(OH)D deficiency was found to be 30% in patients with type 2 DM.…”