Serum 25-hydroxyvitamin D level is negatively associated with serum phosphorus level among stage 3a-5 chronic kidney disease patients

Nokeety, Mahmoud M El; Heikal, Ahmed A.; Marzouk, Khaled; Hammad, Hany; Abdulazim, Dina O.; Salem, Mona M; Din, Usama A Sharaf El

doi:10.1016/j.nefro.2018.02.011

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…In CKD patients with impaired renal phosphate excretion, both 25 (OH)D and 1,25 (OH) 2 D should have positive association with serum phosphorus. The negative association observed in previous studies (12,38) and confirmed in the current study raises many possible mechanisms.…”

Section: Discussionsupporting

confidence: 83%

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Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients

et al. 2019

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Low serum 25 hydroxyvitamin D (25 OH D) is common among chronic kidney disease (CKD) patients. This cross-sectional study is looking for the different factors associated with serum 25 OH D among pre-dialysis CKD. 1624 adult stage 3–5 CKD patients were studied beside 200 normal control subjects. All candidates were tested for body mass index (BMI), estimated glomerular filtration rate (eGFR), calcium (Ca), phosphorus (P), parathormone (PTH), 25 OH D, albumin, and uric acid (UA), and urine albumin/creatinine ratio (ACR). Multivariate linear regression analysis was done to determine predictors of 25 OH D. 98.6% of CKD patients have inadequate level of 25 OH D vs 48% of normal subjects. Serum 25 OH D was significantly lower in CKD patients (mean ± S.D = 16.54 ± 5.8 vs 37.79 ± 3.58 ng/mL for CKD vs control group respectively, p < .001). Serum level of 25 OH D has significant positive correlation with Ca ( r = 0.337, p < .001), and significant negative correlation with P, PTH, UA, and ACR ( r = −0.440, −0. 679, −0.724, and −0.781respectively, p < .001 in all). The independent predictors of 25 OH D were Ca, P, UA, PTH, and ACR (R square = 0.7, β = −0.087, −0.226, −0.313, −0.253, and −0.33 respectively, p < .001 in all). In conclusion, pre-dialysis CKD patients frequently suffer low 25 OH D. Among the different abnormalities related to CKD, urine albumin excretion rate and UA are the most important predictors of 25 OH D in these patients.

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Section: Discussionsupporting

confidence: 83%

“…Increased FGF23 level triggered by increased serum P might inhibit 25 hydroxylase or stimulate 24 hydroxylase. FGF23 negatively correlates with 25 OH D in mice, however, similar relation in human CKD patients was not encountered [38,39].…”

Section: Discussionmentioning

confidence: 99%

Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients

et al. 2019

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“…Desjardins et al. found that FGF23 increased with decreasing kidney function [ 23 , 24 ], while 25(OH)D3 levels decreased with increasing CKD stage in predialysis patients [ 25 , 26 ]. Consistent with these findings, serum 25(OH)D3 levels were negatively correlated with kidney function.…”

Section: Discussionmentioning

confidence: 99%

“…These results suggest that the relationship between FGF23 and CAC is unstable. For the association between 25(OH)D3 and CAC, several studies have shown that low levels of 25(OH)D3 are linked to greater arterial calcification scores [ 25 ] and that patients with higher calcification scores have lower levels of 25(OH)D3 [ 26 ]. However, the study of Pillar et al.…”

Section: Discussionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D3, fibroblast growth factor-23, and C1q/tumor necrosis factor-related protein-3 with coronary artery calcification in nondialysis chronic kidney disease patients

Zhu

et al. 2023

Renal Failure

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Objective To assess serum 25-hydroxyvitamin D3 (25(OH)D3), fibroblast growth factor 23 (FGF23), and C1q/tumor necrosis factor-related protein-3 (CTRP3) levels in nondialysis chronic kidney disease (CKD) patients and their relationship with coronary artery calcification (CAC). Methods One hundred and twenty-eight patients diagnosed with CKD were selected and all underwent cardiac computed tomography. CAC was assessed using the Agatston score, and coronary artery calcification score (CACs) >10 was identified as CAC. The differences in serum 25(OH)D3, FGF23, and CTRP3 levels between the CAC and non-CAC groups were analyzed. Their correlation with CACs was assessed by Spearman’s analysis, and logistic regression analysis was used to find risk factors for CAC. Results Compared to the non-CAC group, the CAC group was older (64.21 ± 9.68 years), with a higher percentage of hypertension (93.10%) and diabetes (63.80%) and higher levels of serum CTRP3 [1079.20 (644.4–1567.2) ng/mL]. However, there was no significant difference in serum 25(OH)D3 and FGF23 between these two groups. The high level CTRP3 group had a higher prevalence of CAC (61.5%). Logistic regression results showed that age, diabetes, decreased 25(OH)D3 (odds ratio (OR) = 0.95, p = .030) and high levels of CTRP3 (OR = 3.19, p = .022) were risk factors for CAC in nondialysis CKD patients. Conclusions Serum CTRP3 levels progressively increased with the progression of kidney disease, while 25(OH)D3 levels progressively decreased. Decreased 25(OH)D3 and high levels of CTRP3 are associated with CAC in patients with nondialysis CKD.

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Native vs. active vitamin D in children with chronic kidney disease: a cross-over study

et al. 2020

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Serum 25-hydroxyvitamin D level is negatively associated with serum phosphorus level among stage 3a-5 chronic kidney disease patients

Abstract: Serum P is likely to have a direct negative impact on serum 25(OH)D. Further studies are needed to determine the underlying mechanism.

Cited by 5 publications

References 25 publications

Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients

Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients

Association of serum 25-hydroxyvitamin D3, fibroblast growth factor-23, and C1q/tumor necrosis factor-related protein-3 with coronary artery calcification in nondialysis chronic kidney disease patients

Native vs. active vitamin D in children with chronic kidney disease: a cross-over study

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