Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Fan, Haiyan; Hui, Lingyun; Yan, Xiaoting; Hou, Wei; Bai, E; Wang, Li; Yu, Xuewen

doi:10.1186/s12905-020-01018-1

Cited by 9 publications

(7 citation statements)

References 35 publications

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“…Consistent with previous studies [ 40 , 41 ], we found that newborns born in winter may have lower 25[OH]D levels. Chongqing, also known as China’s fog capital, has few sunny days in winter.…”

Section: Discussionsupporting

confidence: 93%

Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China

Li¹,

Yu²,

Li³

et al. 2021

BMC Pregnancy Childbirth

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Background Vitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth. Methods A prospective subcohort investigation was carried out among 72 dichorionic, diamniotic twin-pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester, and cord blood was collected from neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected. Results The average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficient and 20.8% insufficient, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficient. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the cotwin birthweight discordance (beta-value: -2.67, 95% CI: − 5.11, − 0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at 6 months than those of mothers with vitamin D sufficiency. Conclusions Twin neonates were at high risk of vitamin D deficiency, although their mothers’ vitamin D deficiency partially improved. Higher maternal vitamin D levels were associated with smaller discordance of cotwin birthweight. Trial registration Chinese Clinical Trial Registry ChiCTR-OOC-16008203, 1st April 2016.

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Section: Discussionsupporting

confidence: 93%

Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China

Li¹,

Yu²,

Li³

et al. 2021

BMC Pregnancy Childbirth

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“…Since 25-(OH) D is relatively stable in the human body, 25-(OH) D is usually used internationally to reflect the body's vitamin D level. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D exists in many forms through multiple metabolisms in the body. Since 25-(OH) D is relatively stable in the human body, 25-(OH) D is usually used internationally to reflect the body's vitamin D level [4] …”

Section: Introductionmentioning

confidence: 99%

“…Since 25-(OH) D is relatively stable in the human body, 25-(OH) D is usually used internationally to reflect the body's vitamin D level. [4] Pregnant women are a special group. During pregnancy, the metabolism and endocrine functions of pregnant women will undergo subtle changes, and the nutrition intake need to meet both their own nutritional needs and the needs of fetal development.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency in pregnant women

Chen

2021

Medicine

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Objective:To analyze the level of vitamin D and its influencing factors in pregnant women, and to explore the influence of vitamin D deficiency on common adverse pregnancy outcomes in pregnant women, providing evidence for prevention and intervention of vitamin D deficiency in pregnant women.Methods:The basic data and blood samples of pregnant women in our hospital from January 2019 to June 2020 were collected, and the 25-(OH) D levels of the serum samples were detected. Then the vitamin D levels and its influencing factors were analyzed, and the relationships between vitamin D levels and common adverse pregnancy outcomes in the pregnant women as well as the incidence of small-for-gestational-age newborns were analyzed.Results:The vitamin D deficiency rate, insufficiency rate and sufficiency rate of pregnant women were 83.28%, 15.36%, and 1.36% respectively, with vast majority of the pregnant women in a state of vitamin D deficiency. Analysis of the influencing factors on the vitamin D level of pregnant women showed “28 weeks ≤ gestational age ≤32 weeks, summer and autumn, high school education and above, weekly time outdoors ≥10 hours, supplement of vitamin D and trace elements during pregnancy” were protective factors for vitamin D sufficiency in pregnant women. Linear correlation analysis showed the vitamin D level of pregnant women was highly positively correlated with temperature, the higher the temperature, the higher the vitamin D level (r = 0.907, t = 6.818, P < .001). The level of vitamin D in pregnant women was related to the occurrence of spontaneous abortion and small-for-gestational age (SGA), with the incidence of spontaneous abortion and SGA in the “vitamin D deficiency group” higher than those of other groups (P = .018, P = .016).Conclusions:The vitamin D level of pregnant women in this area is relatively low, which is affected by multiple factors such as gestational age, season, education level of pregnant women, weekly time outdoors, vitamin D and trace element supplement during pregnancy. Low vitamin D levels can increase the risk of spontaneous abortion and SGA in pregnant women, so relevant measures should be adopted to improve the vitamin D status of pregnant women.

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“…Hydroxy Vit-D was measured by chemiluminescence (CLIA) and classi ed in De cient (<20ng/ml), insu cient (20-29 ng/ml) and su cient level (>29 ng/ml)[21].Malondialdehyde (MDA) is major marker of lipid peroxidation as well as Total oxidants in human serum and it was measured by thio-barbituric acid reactive substances (TBARS) method.National Institutes of Health Stroke Scale (NIHSS)The general and neurological examination was done for assessment of neurological function, within 24 hr of admission of patients using NIHSS score by neurologist. NIHSS score is a neurological examination which directly reveals stroke severity.…”

mentioning

confidence: 99%

A Rigorous Study on Relation of Stroke Risk Factor With Specific Ischemic Brain Stroke in Indian Patients: A Case Control Study

SHRIVASTAV

Verma

TRIPATHI

et al. 2020

Preprint

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BackgroundRecent evidences suggested that deficiency of Vit-D is associated with risk of ischemic stroke and its severity. The mechanism behind its relationship have been linked to total oxidant level and some other modifiable risk factor like hypertension, diabetes, smoking and alcohol consumption and tobacco chewing. However, there are disappearances in evidences. The aim of this study is to find out the role of Vit-D and Total oxidants in ischemic stroke and in disease progression.MethodsIn this case control study total 205 individuals of case and control enrolled in this study the demographic data like age, gender, ethnicity, dietary habit, addiction (smoking, alcohol, tobacco chewing) previous history of disease (hypertension, diabetes, any cardiovascular disease) were collected from family members and other medical record. ResultsThe mean age of case and control group of 63.91 ± 12.66 and 62.52 ± 7.04 respectively. There was significant difference between insufficient Vit-D level in case and control group (p<0.05) however, there were significant difference of MDA in the groups classified on the basis of Vit-D level in case and control (p<0.05) moreover, there were inverse association observed between Vit-D and MDA level in both case and control. Vit-D and MDA shows significant association ischemic stroke however, MDA have association with stroke severity. ConclusionThe result shows higher prevalence of Vit-D deficiency in ischemic stroke patients which induce MDA level parallelly. At low level of Vit-D and high level of MDA associated with the severity of stroke. Moreover, Vit-D and MDA shows significant association with stroke occurrence. Furthermore, MDA significantly associated with stroke severity however Vit-D does not show any association with stroke severity

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Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Cited by 9 publications

References 35 publications

Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China

Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China

Vitamin D deficiency in pregnant women

A Rigorous Study on Relation of Stroke Risk Factor With Specific Ischemic Brain Stroke in Indian Patients: A Case Control Study

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