Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

Maleki, Masoud; Nahidi, Yalda; Azizahari, Sahar; Meibodi, Naser Tayyebi; Hadianfar, Ali

doi:10.1177/1203475415622207

Cited by 37 publications

(39 citation statements)

References 24 publications

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“…In epidermal keratinocytes, the intrinsic danger signals cytosolic DNA and the antimicrobial peptide psoriasin (S100A7) were identified as disease-relevant triggers for caspase-5 activity and IL-1β production in a Th1/Th17 environment. Patients suffering from psoriasis have lower vitamin D levels [32], and we observed that application of vitamin D suppresses caspase-5 in keratinocytes in psoriasis. Current studies link IL-1β production and Th17-mediated effects in autoimmune diseases, including psoriasis, and these observations could contribute to the developing understanding of their pathogenesis and therapeutic interference [2, 33, 34].…”

Section: Discussionmentioning

confidence: 91%

Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

et al. 2017

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IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. Its production is controlled at the transcriptional level and by subsequent posttranslational processing via inflammatory caspases. In this study, we detected inflammatory caspase-5 active in epidermal keratinocytes and in psoriatic skin lesions. Further, interferon-γ and interleukin-17A synergistically induced caspase-5 expression in cultured keratinocytes, which was dependent on the antimicrobial peptide psoriasin (S100A7). However, diseases-relevant triggers for caspase-5 activity and IL-1β production remain unknown. Recently, extranuclear DNA has been identified as danger-signals abundant in the psoriatic epidermis. Here, we could demonstrate that cytosolic double-stranded (ds) DNA transfected into keratinocytes triggered the activation of caspase-5 and the release of IL-1β. Further, interleukin-17A promoted caspase-5 function via facilitation of the NLRP1-inflammasome. Anti-inflammatory vitamin D interfered with the IL-1β release and suppressed caspase-5 in keratinocytes and in psoriatic skin lesions. Our data link the disease-intrinsic danger signals psoriasin (S100A7) and dsDNA for NLPR1-dependent caspase-5 activity in psoriasis providing potential therapeutic targets in Th17-mediated skin autoinflammation.

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Section: Discussionmentioning

confidence: 91%

Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

et al. 2017

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“…Thus, 12 articles, comprising 571 patients with psoriasis and 496 HCs, met the inclusion criteria [5][6][7][8][9][10][11][12][13][14][15][16] ( Table 1). The patients had not been exposed to any drug previously in the studies, there were no patient populations with psoriatic arthritis except in one study, 6 and none of the patients had taken oral corticosteroids that might induce osteopenia/osteoporosis. Except for one, 15 studies did not mention which type of psoriasis (chronic plaque, guttate, palmoplantar, scalp) was considered.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…4 However, studies that have compared circulating 25 (OH)D levels between patients with psoriasis and healthy controls (HCs) and determined the relationship between 25(OH)D levels and psoriasis severity have reported inconsistent results. [5][6][7][8][9][10][11][12][13][14][15][16] To overcome the limitations of individual studies and resolve inconsistencies, we performed a metaanalysis, comparing the serum/plasma 25(OH)D levels between patients with psoriasis and HCs, and evaluated the correlation of these levels with disease severity.…”

Section: Introductionmentioning

confidence: 99%

Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: a meta-analysis

Lee

Song

2018

Clin Exp Dermatol

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“…Vitamin D plays a critical role in psoriasis, and this is evidenced in many studies which reported either a deficiency or insufficiency of serum vitamin D in psoriatic patients [59,60,61]. Several case-control studies have shown significant lower levels of serum 25(OH)D in psoriatic patients compared to controls and reported an inverse correlation between serum 25(OH)D and the severity of the disease [62,63,64,65,66].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

147

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

Abstract: Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.

Cited by 37 publications

References 24 publications

Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: a meta-analysis

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

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