Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Abdelsadek, Seham E.; Saghier, Entesar Oa El; Raheem, Sabah I. Abdel

doi:10.1186/s41983-018-0036-9

Cited by 35 publications

(44 citation statements)

References 47 publications

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“…In studies conducted, Vitamin D levels are observed to be low in DM patients (14,28). Studies showed that Vitamin D deficiency has an effect and an important role in the development and severity of DPN (1,14). In our study, 25 (OH) vitamin D serum levels were significantly lower in patients with PNP than in patients without PNP.…”

Section: Resultssupporting

confidence: 41%

Section: Resultsmentioning

confidence: 99%

“…In studies conducted, age, male gender, duration of diabetes, diabetic control are shown to be risk factors for DPN (10). Elevation of fasting blood sugar and HbA1c levels and low vitamin D values have been reported in many studies to be risk factors for development of DPN (9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Diyabetik Polinöropati Risk Faktörleri

Demirel

Karpuz

Çelebi

et al. 2020

Konuralp Tıp Dergisi

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Objective: Diabetes Mellitus is one of the most common metabolic diseases. The most frequent complication of DM is diabetic polyneuropathy. Diabetic polyneuropathy is related to high mortality, morbidity, hospitalization rate and serious level of economic burden. We aimed in this study to determine the risk factors that affect DPN pathology. Methods: Patients with abnormalities in the nerve conduction study constituted the polyneuropathy group, and patients without abnormalities formed the control group. When the laboratory values of the patients were analyzed, blood tests of 168 of 202 patients were reached. 117 of these patients had PNP and 51 did not have PNP. Results: In patients with PNP, glycolyzed hba1c ratio and fasting blood sugar were significantly higher than patients without PNP (p<.001). While HDL rate was lower in patients with PNP than those without PNP (p<0.01), TG/HDL ratio was higher (p<0.05). In patients with PNP, glycolyzed urea (p<0.001) and creatinine (p<0.01) were significantly higher than those without PNP. The serum level of 25(OH) vitamin D was significantly lower in patients with PNP than in patients without PNP (p<0.05). Ferritin was significantly higher in patients with PNP than patients without (p<0 .01). Conclusions: Knowing and preventing risk factors for diabetic polyneuropathy, we can take a new direction to our treatment approaches and take early measures. Fasting blood sugar and hba1c control, regulation of lipid profile, monitoring of vitamin d and ferritin levels are particularly necessary for protection of polyneuropathy.

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Section: Resultssupporting

confidence: 41%

Section: Resultsmentioning

confidence: 99%

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Diyabetik Polinöropati Risk Faktörleri

Demirel

Karpuz

Çelebi

et al. 2020

Konuralp Tıp Dergisi

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“…Regarding the association of vitamin D level with diabetic neuropathy, a recent meta-analysis has shown that vitamin D deficiency could be associated with the development of diabetic neuropathy in Caucasian patients with type 2 DM 13. A number of other studies conducted on different populations have also shown an association between the levels of serum vitamin D and diabetic neuropathy 12 25–27…”

Section: Introductionmentioning

confidence: 99%

Neuropathic pain is not associated with serum vitamin D but is associated with female gender in patients with type 2 diabetes mellitus

Alkhatatbeh

Abdul‐Razzak

2019

BMJ Open Diab Res Care

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ObjectiveNeuropathic pain is a common complication of diabetes mellitus (DM). Patients may complain of several neuropathic symptoms including impaired peripheral sensation, numbness, tingling, burning, and pain. Because these symptoms may cross with symptoms of vitamin D deficiency, we hypothesized that neuropathic pain and vitamin D deficiency may be associated in patients with type 2 DM.Research design and methodsThis is a cross-sectional study that involved 239 participants with type 2 DM. Neuropathic pain was assessed using PainDETECT questionnaire. Serum 25-hydroxyvitamin D was measured by the electrochemiluminescence immunoassay, fasting blood glucose was measured by the hexokinase method and hemoglobin A1c was measured by the turbidimetric inhibition immunoassay.ResultsThe prevalence of neuropathic pain among type 2 DM participants was 26.8%. Vitamin D deficiency was reported in 67.8% of type 2 DM participants. The neuropathy score for females was significantly higher than that for males (p<0.01). There was no significant difference in serum vitamin D between type 2 DM participants according to their gender and according to their neuropathy status (p>0.05). Ordinal logistic regression analysis has shown that female gender was the only significant predictor of neuropathic pain among type 2 DM participants (p<0.01 with an OR (95% CI) of 2.45 (1.29 to 4.67)).ConclusionsNeuropathic pain was not associated with serum vitamin D but was associated with female gender in type 2 DM. Because our results were not consistent with other studies that used different neuropathy assessment tools, we suggest that further research should be conducted to check the validity of these tools in identifying subjects with neuropathy.

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“…Abdelsadek et al, 25 also found significant correlations between vitamin 25(OH)D level and amplitudes of motor peroneal, sensory median, and sensory sural nerves and the NCV of the sensory sural nerves ( p < 0.001). Lower levels of vitamin 25(OH)D were associated with a decrease in NCV of peroneal and sural nerves.…”

Section: Discussionmentioning

confidence: 87%

Modulation of Interleukin-8 Production by Vitamin D Supplementation in Indonesian Patients with Diabetic Polyneuropathy: A Randomized Clinical Trial

et al. 2020

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Objectives We sought to assess the modulation of interleukin-8 (IL-8) production by vitamin D supplementation in Indonesian patients with diabetic polyneuropathy (DPN). Methods We conducted a cohort prospective, randomized, placebo-controlled, double-blind trial. This study was approved by the Local Ethical Committee and conducted from July 2018 to February 2019. We recruited 50 subjects with type 2 diabetes mellitus attending Haji Adam Malik General Hospital Medan, and divided them into two groups. The groups were treated for 10 weeks, either with placebo or vitamin D (D 3 ) supplementation of 50 000 IU/week. They were evaluated by routine nerve conduction study (NCS) in the upper and lower limbs, and their serum vitamin 25-hydroxyvitamin D (25(OH)D) and IL-8 levels before and 10 weeks after placebo or vitamin D supplementation were measured. The role of IL-8 and vitamin D supplementation on the NCS was analyzed using linear regression. Results There was a significant difference between the mean vitamin 25(OH)D ( p = 0.001) and IL-8 levels ( p = 0.002) before and after vitamin D supplementation. There was no significant correlation between changes in vitamin 25(OH)D and IL-8 levels ( p = 0.743). There was significant role of IL-8 on amplitude of the sensory sural nerve ( p = 0.047; B = -0.009) and the nerve conduction velocity (NCV) of the motor tibial nerve ( p = 0.007; B = -0.027). There was a significant role of vitamin D supplementation on NCSs. Conclusions Higher IL-8 levels were correlated with poorer amplitude of the sensory sural nerve and the NCV of motor tibial nerves. Lower vitamin 25(OH)D levels were correlated with poorer distal latencies, amplitudes, and NCVs. There was no significant correlation between vitamin 25(OH)D and IL-8 levels. Thus, no sufficient evidence that vitamin D supplementation modulates IL–8 in Indonesian patients with DPN. Vitamin D 3 improved NCSs in diabetic patients.

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Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Cited by 35 publications

References 47 publications

Diyabetik Polinöropati Risk Faktörleri

Diyabetik Polinöropati Risk Faktörleri

Neuropathic pain is not associated with serum vitamin D but is associated with female gender in patients with type 2 diabetes mellitus

Modulation of Interleukin-8 Production by Vitamin D Supplementation in Indonesian Patients with Diabetic Polyneuropathy: A Randomized Clinical Trial

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