Serum-5-Hydroxytryptamine Levels Following Experimental Increase in Gastrointestinal Activity in Man

Adams, B. G.

doi:10.1016/s0140-6736(60)90119-7

Cited by 17 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bulbring and Lin (1958) find that not only is peristalsis increased by intraluminal administration of 5HT but that intraluminal stimulation itself caused liberation of 5HT. Also, Adams (1960) has reported that the administration of magnesium sulphate or carbachol results in elevated serum 5HT.…”

Section: Discussionmentioning

confidence: 99%

Excretion of 5-hydroxyindolyl acetic acid (5HIAA) in migraine.

Curzon¹,

Theaker²,

Phillips³

1966

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

During the prodromal phase of a migraine attack, vasoconstriction occurs which is followed during headache by the dilatation of cranial blood vessels (Marcussen and Wolff, 1950). Therefore, the metabolism in migraine of physiologically occurring vasoactive substances such as 5-hydroxytryptamine (5HT) and the catecholamines is of interest. A further indication of the possible importance of 5HT is that ergot alkaloids, such as methysergide, used in the treatment of migraine are pharmacological antagonists of this substance. In particular, Sicuteri, Fanciullacci, Del Bianco, and Franchi (1964) find that methysergide prevents the venoconstrictive effect of 5HT. Sicuteri, Testi, and Anselmi (1961) have reported elevated 24-hour excretion of 5HIAA (the main urinary metabolite of 5HT) by some migraine patients on the days during which attacks occurred.Excretion of 3-methoxy-4-hydroxymandelic acid (V.M.A.), the main urinary metabolite of noradrenaline and adrenaline, has also been claimed by Sicuteri (1963) to be raised during attacks.Because of these observations, it was thought worthwhile to investigate 5HIAA excretion in migraine in greater detail, paying particular attention to the control of extraneous factors known to affect excretion of this substance. The excretions by some of the patients of another tryptophan metabolite, indoxyl sulphate, and of V.M.A. were also measured. MATERIALS PATIENTS The 13 patients studied in the main series of experiments included nine migraine subjects and four controls. The migraine subjects were subject to frequent attacks and admitted to hospital specifically for this reason, there being no evidence of any other organic disease. The control subjects were patients in a neurological hospital without demonstrable organic neurological disease or vascular or gastrointestinal disease. The patients cooperated actively in the study and filled in daily charts giving chronological and symptomatic details of their headaches. All patients were ambulant.Except where specifically stated otherwise, the normal hospital diet was used except that the following foods, which are known to contain 5HT in considerable amount, were excluded from the diet: bananas (Waalkes, Sjoerdsma, Creveling, Weissbach, and Udenfriend, 1958), pineapple (Bruce, 1960), walnuts (Kirberger and Braun, 1961), grapefruit and apricots (West, 1958). Alcohol was not allowed as it has been reported by Rosenfeld (1960) to influence 5HIAA excretion. Patients were taken off all drugs three days before the start of investigations. The daily fluid intake of each subject was controlled to a fixed volume.URINE COLLECTIONS Urine specimens were collected over four-hour periods for a varying number of days. Each specimen was collected into 1 ml. of 6N HCI, and on completion, placed in a cold room at 4°C. After measurement of volume, 50-100 ml. samples were stored at -25°C. until determinations were made. METHODS5HmiA An 1/80 sample of each four-hourly urine specimen was brought to 9 ml. with water and used for each determination, thus avo...

show abstract

Section: Discussionmentioning

confidence: 99%

Excretion of 5-hydroxyindolyl acetic acid (5HIAA) in migraine.

Curzon¹,

Theaker²,

Phillips³

1966

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…Hence, it can be assumed that under the 'Normal' and 'Niamid' conditions the endogenous 5-HT was released directly into the serosal fluid and that release into the lumen with subsequent absorption did not occur. The evidence that endogenous 5-HT is released into the serosal fluid adds further support to the view that blood 5-HT is derived from the intestine (Toh, 1954;Erspamer & Testini, 1959;Adams, 1960;Bertaccini, 1960;Stacey & Young, 1964).…”

Section: Discussionmentioning

confidence: 54%

The release of 5‐hydroxytryptamine from rabbit small intestine in vitro

Gwee¹,

Yeoh²

1968

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. A method is described by which the lumen of intestinal segments may be perfused separately and simultaneously under identical conditions of perfusion pressure and temperature, and the rate of appearance of 5-hydroxytryptamine (5-HT) into the serosal fluid measured.2. 5-HT appeared in the serosal fluid from quiescent segments of rabbit intestine at a rate of about 4 0 ng/cm intestine/hr and about 14-0 ng/cm intestine/hr from segments performing active peristaltic movements.3. For both quiescent and active segments, when the perfusion fluid contained a monoamine oxidase inhibitor, nialamide (Niamid), the rate of appearance of 5-HT was increased and if, in addition, 5-HT was present in the perfusion fluid the rate of appearance of 5-HT in the serosal fluid was even greater.4. The rate of appearance of 5-HT from the intestine of rabbits pretreated with reserpine was about 08 ng/cm intestine/hr and Niamid only slightly increased this rate. However, if 5-HT as well as Niamid were present the rate of appearance of 5-HT was about 6-0 ng/cm intestine/hr. 5. Possible explanations for these findings are discussed.

show abstract

Brain Amine Metabolism in Some Neurological and Psychiatric Disorders

Curzon¹

1972

Biochemical Aspects of Nervous Diseases

View full text Add to dashboard Cite

Serum-5-Hydroxytryptamine Levels Following Experimental Increase in Gastrointestinal Activity in Man

Cited by 17 publications

References 6 publications

Excretion of 5-hydroxyindolyl acetic acid (5HIAA) in migraine.

Excretion of 5-hydroxyindolyl acetic acid (5HIAA) in migraine.

The release of 5‐hydroxytryptamine from rabbit small intestine in vitro

Brain Amine Metabolism in Some Neurological and Psychiatric Disorders

Contact Info

Product

Resources

About