Serum acute phase proteins in control and Theileria annulata infected water buffaloes (Bubalus bubalis)

El-Deeb, Wael; Iacob, O. C.

doi:10.1016/j.vetpar.2012.06.019

Cited by 23 publications

(8 citation statements)

References 36 publications

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“…The activated lymphocytes have been shown to secrete several cytokines including TNF-a, interleukin-1 and interferon gamma which are able to express HLADR antigens and stimulate fibroblasts to proliferate, produces GAG and free oxygen radicals. The pathological changes observed in different organs and tissues of T. annulata infected animals are the result of proliferation of infected macrophages, while other clinical symptoms result from pro-inflammatory cytokines produced by these cells, mainly TNF-a (Branco et al 2010;El-Deeb and Iacob 2012). Thus, it is quite possible that the infiltration of lymphocytes and overproduction of TNF-a be implicated in ophthalmopathy of calf theileriosis.…”

Section: Clinical Examination Results and Discussionmentioning

confidence: 99%

Salvage of Theileria infected calves with clinical manifestation of exophthalmia

et al. 2013

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Two crossbred female calves aged between 30 and 35 days were presented with bilateral exophthalmia, inappetence, pyrexia and cachexia since last 15 days. Clinical examination revealed mainly bilateral exophthalmia with dry and pulpy cornea, generalized enlargement of superficial lymph nodes, pallor mucous, petechiae, high rectal temperature and sternal recumbency. The calves were severely infested with Hyalomma anatolicum anatolicum ticks and thin layer blood smears revealed presence of piroplasm in the RBCs, while lymph nodes aspirate smear examination revealed presence schizonts in the mononuclear cells. The calves were treated with buparvaquone; meloxicam, nandrolone decanoate and vitamins A, D 3 , E and H. From day second post-therapy a remarkable improvement in the clinical condition was noticed and substantial reduction in the both protruded eyeballs was noticed by 7 days post-therapy in the both calves. Further at day 47 post-therapy the one calf was free from the parasite on blood smear examination and right eye was retracted in its orbits with full of sight. Moreover the left eye was also retracted in its orbit but there was loss of sight and opacity developed in this eye. While, the other calf also revealed remarkable improvement in the clinical condition and both eye balls retracted completely into the orbit at day 30 post-therapy. But, at day 86 the calf developed microphthalmia and complete loss of sight in both eyes. It can be concluded that adjunction of antioxidants and hematopoietic agents may salvage the calves suffering from fatal theileriosis.

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Section: Clinical Examination Results and Discussionmentioning

confidence: 99%

Salvage of Theileria infected calves with clinical manifestation of exophthalmia

et al. 2013

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“…Leukopaenia was found in Egyptian buffaloes with tropical theileriosis [ 75 , 76 ]. Thrombocytopaenia and panleukopaenia were remarkable findings in T. annulata -infected Egyptian water buffaloes [ 82 ]. Variability in reported leukocyte and platelet count changes can be due to the phase of disease.…”

Section: Clinical Pathology Of Theileria -Infecmentioning

confidence: 99%

“…Anaemic cross-bred cows with tropical theileriosis had significant decreased levels of sodium, ionized calcium, total protein and albumin compared to non anaemic cows, and increased concentrations of blood urea nitrogen and creatinine [ 56 ]. El-Deeb and Iacob [ 82 ] reported significant increases in the levels of acute phase positive markers, such as haptoglobin, serum amyloid A, ceruloplasmin, α1-acid glycoprotein and fibrinogen levels in T. annulata -infected water buffaloes. Similarly, sialic acid value increased in T. annulata -infected Holstein cattle as well as adenosine deaminase activity, while total antioxidant capacity dropped [ 62 ].…”

Section: Clinical Pathology Of Theileria -Infecmentioning

confidence: 99%

Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: A Review

et al. 2020

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Theileriosis is a blood piroplasmic disease that adversely affects the livestock industry, especially in tropical and sub-tropical countries. It is caused by haemoprotozoan of the Theileria genus, transmitted by hard ticks and which possesses a complex life cycle. The clinical course of the disease ranges from benign to lethal, but subclinical infections can occur depending on the infecting Theileria species. The main clinical and clinicopathological manifestations of acute disease include fever, lymphadenopathy, anorexia and severe loss of condition, conjunctivitis, and pale mucous membranes that are associated with Theileria-induced immune-mediated haemolytic anaemia and/or non-regenerative anaemia. Additionally, jaundice, increases in hepatic enzymes, and variable leukocyte count changes are seen. Theileria annulata and Theileria parva induce an incomplete transformation of lymphoid and myeloid cell lineages, and these cells possess certain phenotypes of cancer cells. Pathogenic genotypes of Theileria orientalis have been recently associated with severe production losses in Southeast Asia and some parts of Europe. The infection and treatment method (ITM) is currently used in the control and prevention of T. parva infection, and recombinant vaccines are still under evaluation. The use of gene gun immunization against T. parva infection has been recently evaluated. This review, therefore, provides an overview of the clinicopathological and immunopathological profiles of Theileria-infected cattle and focus on DNA vaccines consisting of plasmid DNA with genes of interest, molecular adjuvants, and chitosan as the most promising next-generation vaccine against bovine theileriosis.

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“…In bovine and camels, several studies have been conducted to elucidate the role of APPs in different disorders including parasitic and bacterial infection ( El-Deeb & Iacob , 2012 ; El-Deeb, Fouda & El-Bahr , 2014 ; El-Deeb , 2015 ; El-Deeb & Elmoslemany , 2016 ; El-Deeb & Buczinski , 2015 ). Conversely, only a limited number of studies have been done regarding specific bacterial, viral or parasitic infections in ovine species ( El-Deeb , 2013 ; El-Deeb & Tharwat , 2015 ).…”

Section: Introductionmentioning

confidence: 99%

The diagnostic accuracy of acute phase proteins and proinflammatory cytokines in sheep with pneumonic pasteurellosis

El-Deeb

Elmoslemany

2016

PeerJ

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The goal of this study was to assess the diagnostic accuracy of acute phase proteins and proinflammatory cytokines in sheep with pneumonic pasteurellosis. Blood samples were collected from 56 sheep (36 naturally infected with Pasteurella multocida and 20 healthy controls) belonging to one farm in Eastern region, Saudi Arabia. Serum samples were evaluated for acute phase proteins (Haptoglobin (Hp), serum amyloid A (SAA) and fibrinogen (Fb)), and the proinflammatory cytokines (interleukins (IL-1α, IL-1β, and IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-ϒ)). Additionally, nasopharyngeal swabs and bronchoalveolar lavages were collected from all animals for bacteriological examinations. Receiver operating characteristic curve was used to assess the diagnostic performance of each parameter. All parameters showed moderate to high degree of positive correlation with case-control status. There was no significant difference in the area under the curve (AUC) among acute phase proteins; however, both Hp and SAA showed better sensitivity and specificity than Fb. The proinflammatory cytokines (IL1-α, IL1-β, and IL6) showed similar and highly accurate diagnostic performance (AUC > 0.9), whereas IFN-ϒ was moderately accurate (AUC = 0.79). In conclusion, this study confirms the value of acute phase proteins and cytokines as diagnostic biomarkers of naturally occuring pneumonic pasteurellosis in sheep.

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Serum acute phase proteins in control and Theileria annulata infected water buffaloes (Bubalus bubalis)

Cited by 23 publications

References 36 publications

Salvage of Theileria infected calves with clinical manifestation of exophthalmia

Salvage of Theileria infected calves with clinical manifestation of exophthalmia

Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: A Review

The diagnostic accuracy of acute phase proteins and proinflammatory cytokines in sheep with pneumonic pasteurellosis

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