Serum adenosine deaminase activity and its isoenzyme pattern in women with normal pregnancies

Yoneyama, Yoshio; Suzuki, Shunji; Sawa, Rintaro; Otsubo, Yasuo; Miura, Asako; Kuwabara, Yoshimitsu; Ishino, Hiroshi; Kiyokawa, Yasuko; Doi, D.; Yoneyama, Kihei; Araki, Tsutomu

doi:10.1007/s00404-002-0312-9

Cited by 26 publications

(21 citation statements)

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“…Whereas the uncommon genetic deficiency of ADA severely impairs multiple immune responses in effected individuals, our discovery of a relative physiologic ADA deficiency that is apparently normal at birth and early infancy suggests a potential mechanism that may contribute to the general susceptibility of healthy newborns to bacterial, mycobacterial, and viral infections (64). Of note, a similar profile (elevated plasma AP (65), 5′-NT (66), and eAdo (66) and lower total ADA (but not lower ADA1) (67)) is found during pregnancy, another functionally distinct immunologic state associated with impaired Th1-polarizing cytokine responses and enhanced susceptibility to intracellular pathogens (68, 69). …”

Section: Discussionmentioning

confidence: 80%

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

Pettengill

Robson

Tresenriter

et al. 2013

Journal of Biological Chemistry

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Background: Newborns have elevated plasma adenosine levels, which may influence their immunological function.Results: Compared with adults, newborns have elevated plasma 5′-NT and alkaline phosphatase activities and lower adenosine deaminase activity.Conclusion: Soluble enzymes significantly influence extracellular purine metabolism in blood, and the levels of these enzymes in newborns promote elevated adenosine.Significance: Higher adenosine generation in newborn blood may promote an anti-inflammatory immunological status.

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Section: Discussionmentioning

confidence: 80%

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

Pettengill

Robson

Tresenriter

et al. 2013

Journal of Biological Chemistry

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“…Thus, it would be interesting to see if the change in the serum ADA activity is accompanied by similar changes in ADA isoforms, especially ADA2. Despite the limitations of the this study, we were able to provide serum ADA values throughout normal pregnancy from early first trimester to third trimester which was different from previous studies that only compared the serum ADA activity of pregnant women in their third trimester to the non-pregnant controls (16). …”

Section: Discussionmentioning

confidence: 88%

“…In normal pregnant women, serum total ADA and ADA2 activities were lower than those of the nonpregnant women, while there was no difference in ADA1 activity. These results suggest that reduced serum total ADA activity reflects decreased ADA2 activity, which may be in part associated with depressed cell-mediated immunity during normal pregnancy (16). One possible explanation for decreased ADA activity in normal pregnancy is due to the increase in pregnancy-related hormones such as estradiol and cortisol which tends to inhibit ADA activity (22).…”

Section: Discussionmentioning

confidence: 95%

“…Yoneyama et al have measured serum activities of total ADA, ADA1, and ADA2 in normal pregnant women in the third trimester and age-matched healthy nonpregnant women (16). In normal pregnant women, serum total ADA and ADA2 activities were lower than those of the nonpregnant women, while there was no difference in ADA1 activity.…”

Section: Discussionmentioning

confidence: 99%

“…There have been conflicting reports about the changes in the activity of serum ADA in normal pregnancy compared to the age-matched non-pregnant women (14-16). However, to our knowledge, only few studies have been performed investigating the changes in serum ADA activity according to gestational age, and the clinical significance of changes in ADA activity throughout normal pregnancy has not been elucidated (14, 15).…”

Section: Introductionmentioning

confidence: 99%

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Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

et al. 2007

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Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the changes in serum ADA activity throughout normal pregnancy. We measured the catalytic values of serum ADA from 202 normal pregnant women using a commercial kit. Subjects were divided into four groups according to the gestational age in weeks (Gwks) (Group I: 5-9 Gwks [n=58]; Group II: 15-20 Gwks [n= 63]; Group III: 24-30 Gwks [n=34]; Group IV: 30-39 Gwks [n=47]). The serum ADA levels for the Groups I, II, III, and IV were as follows: 20.1±6.9 IU/L, 20.0±7.6 IU/L, 37.9±19.9 IU/L, and 24.5±8.6 IU/L, respectively. The serum ADA activity of group III was significantly higher than the other groups (p<0.05). However, there was no significant correlation between the Gwks and the serum ADA activity. Furthermore, other parameters, such as maternal age (p=0.29), gestational age at delivery (p=0.07), delivery mode (p=0.39), and birth weight (p=0.59) had no correlation with ADA activity. Reference values of serum ADA in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered.

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Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Sulaiman

Tawfeeq

Jaaffer

2017

Biotechnology Progress

114

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Copper oxide nanoparticles (CUNPs) were synthesized using Olea europaea leaf extract as reducing and protecting agent. The formation of nanoparticles was observed through a color change from yellowish to brownish black. The CUNPs were confirmed with UV-Vis spectrophotometer, which revealed a peak absorbance at 289 nm. The synthesized CUNPs were characterized by XRD, FTIR, SEM, and TEM. The XRD pattern revealed that CUNPs were crystalline in nature with a diameter around 20 nm. FTIR spectral analysis showed that CUNPs were capped with plant constituents. From SEM and TEM analyses, the CUNPs were generally found to be spherical in shape, and the size range was 20-50 nm. Free radical scavenging potential of CUNPs against DPPH was confirmed by its stable antioxidant effects. In addition, the toxicity of CUNPs in mice was also assessed by body weight and weights of liver, kidneys, spleen, and thymus. The immune response in mice was signaled through an obvious change in spleen and thymus index, with a decrease of ADA enzyme activity in serum, spleen, and thymus after CUNPs treatment. The CUNPs were found to exert cell growth arrest against AMJ-13 and SKOV-3 cancer cells in a dose-dependent manner and induce cell death by apoptosis. Less significant cytotoxic effect was observed in normal dermal fibroblast cells. These findings suggest that CUNPs may have the potential to be anticancer agents. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:218-230, 2018.

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Serum adenosine deaminase activity and its isoenzyme pattern in women with normal pregnancies

Cited by 26 publications

References 10 publications

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

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