Serum Adiponectin and Poor Physical Fitness in the Community-Dwelling Elderly

Huang, Chuanhe; Hozawa, Atsushi; Tomata, Yasutake; Kakizaki, Masako; Sugawara, Yumi; Momma, Haruki; Tsuji, Ichiro; Nagatomi, Ryoichi

doi:10.1249/01.mss.0000495432.12708.fd

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“…Several critical signaling pathways correlated with ageing‐related hallmarks can further promote the ageing process. It is worth noting that ageing‐related IR usually presents low circulating adiponectin concentrations and tissue adiponectin receptor (AdipoR) levels . Adiponectin, known as an adipocytokine secreted from adipose tissue, is involved in diverse biological processes, including sensitization of the insulin receptor signaling pathway, suppression of inflammation, and stimulation of mitochondria biogenesis .…”

Section: Introductionmentioning

confidence: 99%

6‐Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC‐1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1

Liu

Yao

Wang

et al. 2019

Molecular Nutrition Food Res

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Scope This study investigates the dual actions of 6‐gingerol in stimulating both plasma adiponectin and muscular adiponectin receptor signaling in naturally ageing rats. Methods and results Twenty‐two‐month‐old male SD rats were treated with 6‐gingerol (0.2 mg kg–1, once daily) for 7 weeks. 6‐Gingerol can attenuate age‐associated high plasma triglyceride, glucose, and insulin concentrations under fasting conditions as well as suppress the increase in the HOMA‐IR index and inhibit the decrease of muscular p‐Akt/Akt protein in ageing rats, which indicates an improvement of systemic and muscular insulin sensitivity. Accompanying these changes, treatment with 6‐gingerol attenuates excessive triglyceride accumulation, enhances mitochondrial function, and promotes a transition from a fast‐ to slow‐fiber type and muscle oxidative metabolism in the red gastrocnemius of ageing rats. More importantly, 6‐gingerol not only increases the plasma and adipose tissue adiponectin concentrations, but also elevates muscular AdipoR1 expression and activates downstream AMPK phosphorylation as well as upregulates PGC‐1α in vivo and in vitro. Conclusion 6‐Gingerol may improve ectopic lipid accumulation, mitochondrial dysfunction, and insulin resistance in skeletal muscle of ageing rats. These effects rely, at least in part, on the elevated plasma adiponectin concentration and muscle AdipoR1 level to dually activate the AMPK/PGC‐1α signaling pathway.

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Section: Introductionmentioning

confidence: 99%