Serum adiponectin and resistin: Correlation with metabolic syndrome and its associated criteria among temiar subtribe in Malaysia

Zahary, Mohd Nizam; Harun, Nur Sakinah; Yahaya, Rosliza; Him, Nik Ahmad Shaiffudin Nik; Rohin, Mohd Adzim Khalili; Ridzwan, Nur Haslinda; Jumli, Mimie Noratiqah; Jusoh, Azizul Fadzli

doi:10.1016/j.dsx.2019.04.048

Cited by 7 publications

(11 citation statements)

References 37 publications

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“…We therefore postulated that this association may be moderated by body composition, as is reported in animal models [ 123 ], although we could not confirm the other interrelations between IL-6, low level of HDL-C and elevated TGs reported in humans elsewhere [ 13 , 28 ]. Comparably, for resistin, the association with cardiometabolic risk seems to be moderated by body composition in line with previous literature [ 58 ]; nevertheless, previous studies also reported an association between resistin and other inflammatory cytokines, such as IL-6 and TNF-α, together with a diagnostic ability to predict human coronary atherosclerosis [ 63 , 64 ], which are the findings unconfirmed in the current study.…”

Section: Discussionsupporting

confidence: 92%

“…Resistin is a peptide hormone that performs several functions in metabolism and possesses physiological roles linked to inflammation [ 55 ], endothelial dysfunction [ 56 ], cardiomyocyte function [ 57 ], as well as cholesterol metabolism [ 58 ]. Literature about the role of Resistin in insulin sensitivity and obesity is controversial due to the difference between human and rodent resistin [ 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, resistin may represent a novel link between metabolic signals, inflammation and atherosclerosis [ 63 , 64 ]. Zahary et al [ 58 ] reported that serum resistin is positively correlated with few CM risk factors such as BMI, WC, FBG and total cholesterol. Moreover, the Multi-Ethnic Study of Atherosclerosis (MESA), which included 1913 participants from different ethnicities in the USA, concluded that there was a strong correlation between elevated circulatory resistin and the increased incidence of heart failure, all CVD events independent of traditional cardiovascular risk factors, obesity, markers of inflammation/IR and several adipokines [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Power of Circulatory Metabolic Biomarkers as Metabolic Syndrome Risk Predictors in Community-Dwelling Older Adults in Northwest of England (A Feasibility Study)

et al. 2021

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Background: Metabolic Syndrome (MetS) is a cluster of risk factors for diabetes and cardiovascular diseases with pathophysiology strongly linked to aging. A range of circulatory metabolic biomarkers such as inflammatory adipokines have been associated with MetS; however, the diagnostic power of these markers as MetS risk correlates in elderly has yet to be elucidated. This cross-sectional study investigated the diagnostic power of circulatory metabolic biomarkers as MetS risk correlates in older adults. Methods: Hundred community dwelling older adults (mean age: 68.7 years) were recruited in a study, where their blood pressure, body composition and Pulse Wave Velocity (PWV) were measured; and their fasting capillary and venous blood were collected. The components of the MetS; and the serum concentrations of Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), Plasminogen Activator Inhibitor-I (PAI-I), Leptin, Adiponectin, Resistin, Cystatin-C, C-Reactive Protein (CRP), insulin and ferritin were measured within the laboratory, and the HOMA1-IR and Atherogenic Index of Plasma (AIP) were calculated. Results: Apart from other markers which were related with some cardiometabolic (CM) risk, after Bonferroni correction insulin had significant association with all components of Mets and AIP. These associations also remained significant in multivariate regression. The multivariate odds ratio (OR with 95% confidence interval (CI)) showed a statistically significant association between IL-6 (OR: 1.32 (1.06–1.64)), TNF-α (OR: 1.37 (1.02–1.84)), Resistin (OR: 1.27 (1.04–1.54)) and CRP (OR: 1.29 (1.09–1.54)) with MetS risk; however, these associations were not found when the model was adjusted for age, dietary intake and adiposity. In unadjusted models, insulin was consistently statistically associated with at least two CM risk factors (OR: 1.33 (1.16–1.53)) and MetS risk (OR: 1.24 (1.12–1.37)) and in adjusted models it was found to be associated with at least two CM risk factors and MetS risk (OR: 1.87 (1.24–2.83) and OR: 1.25 (1.09–1.43)) respectively. Area under curve (AUC) for receiver operating characteristics (ROC) demonstrated a good discriminatory diagnostics power of insulin with AUC: 0.775 (0.683–0.866) and 0.785 by cross validation and bootstrapping samples for at least two CM risk factors and AUC: 0.773 (0.653–0.893) and 0.783 by cross validation and bootstrapping samples for MetS risk. This was superior to all other AUC reported from the ROC analysis of other biomarkers. Area under precision-recall curve for insulin was also superior to all other markers (0.839 and 0.586 for at least two CM risk factors and MetS, respectively). Conclusion: Fasting serum insulin concentration was statistically linked with MetS and its risk, and this link is stronger than all other biomarkers. Our ROC analysis confirmed the discriminatory diagnostic power of insulin as CM and MetS risk correlate in older adults.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic Power of Circulatory Metabolic Biomarkers as Metabolic Syndrome Risk Predictors in Community-Dwelling Older Adults in Northwest of England (A Feasibility Study)

et al. 2021

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“…Serum adiponectin level is low in women with type 2 DM, obesity, and insulin resistance. In studies with PCOS, plasma adiponectin level was also found to be low (12).…”

Section: Androgen Excess Society Criteriamentioning

confidence: 97%

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

Ünal¹,

Demirci²,

Yılmaz³

et al. 2020

Istanbul Med J

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Polikistik over sendromu, karotis arter intima media kalınlığı, insülin direnci, apelin, adiponektin, C-reaktif protein treatment groups (p>0.05). There was no statistically significant change in carotid IMT value in all treatment groups (p>0.05). Conclusion: According to these results, we can say that women with PCOS have subclinical atherosclerosis and that metformin treatment has a positive effect on subclinical atherosclerosis.

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“…Кроме того, по мнению некоторых авторов, при СД 2 типа резистин способен стимулировать окислительный стресс, тромбоксан-зависимую активацию тромбоцитов и высвобождение тромбоцитарных воспалительных белков, ключевых детерминант атеротромбоза [47]. Таким образом, резистин может принимать участие в формировании компонентов метаболического синдрома [10] и даже, по прогнозам некоторых исследователей, быть его маркером [48].…”

Section: другие адипокиныunclassified

The Role of Adipokines in the Development of Metabolic Disorders in Schizophrenic Patients

Озорнин¹,

Govorin²,

Sakharov³

2020

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Цель обзора: систематизация научных данных о влиянии адипокинов на формирование метаболического синдрома у больных шизофренией. Основные положения. Лептин и адипонектин участвуют в регуляции метаболических процессов организма, поэтому изменение их концентраций имеет значение для формирования метаболических расстройств. Многочисленными исследованиями установлено, что у больных шизофренией на фоне психофармакотерапии увеличивается содержание лептина и снижается концентрация адипонектина, причем более выраженные изменения происходят при терапии антипсихотиками второго поколения (клозапином, оланзапином, кветиапином). Установлены корреляции между изменениями содержания лептина и адипонектина и некоторыми метаболическими нарушениями. При этом если лептин и адипонектин изучены глубоко и разносторонне, то роль других адипокинов в формировании компонентов метаболического синдрома при шизофрении требует дальнейшего уточнения, в том числе в условиях психофармакотерапии и с учетом генетических особенностей пациентов. Заключение. Установление закономерностей изменения содержания адипокинов у больных шизофренией при нейролептической терапии с учетом их генетических особенностей позволит производить индивидуальное прогнозирование возникновения метаболического синдрома, что, несомненно, положительно отразится на их соматическом состоянии и качестве жизни. Ключевые слова: адипокины, шизофрения, нейролептики, метаболический синдром.

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Serum adiponectin and resistin: Correlation with metabolic syndrome and its associated criteria among temiar subtribe in Malaysia

Cited by 7 publications

References 37 publications

Diagnostic Power of Circulatory Metabolic Biomarkers as Metabolic Syndrome Risk Predictors in Community-Dwelling Older Adults in Northwest of England (A Feasibility Study)

Diagnostic Power of Circulatory Metabolic Biomarkers as Metabolic Syndrome Risk Predictors in Community-Dwelling Older Adults in Northwest of England (A Feasibility Study)

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

The Role of Adipokines in the Development of Metabolic Disorders in Schizophrenic Patients

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