Serum adiponectin is a negative predictor of central arterial stiffness in kidney transplant patients

Ho, Ching-Chun; Hsu, Bang‐Gee; Yin, Weiqiang; Ho, Guan-Jin; Chen, Yen-Cheng; Lee, Ming-Che

doi:10.3109/00365513.2016.1149614

Cited by 7 publications

(15 citation statements)

References 32 publications

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“…Adiponectin has anti-inflammatory, anti-atherosclerotic, and insulin-sensitizing activities and protects against the development of metabolic disorders and their related vascular damage [ 28 ]. Clinical studies have shown that serum adiponectin levels are independent predictors of peripheral arterial stiffness measured by brachial-ankle pulse wave velocity in hypertensive patients with metabolic syndrome and that is negatively associated with cfPWV values in healthy men, kidney transplant patients, and patients undergoing chronic hemodialysis [ 9 18 19 29 ]. In this study, we also found the serum adiponectin levels to be negatively associated with cfPWV values among our patients.…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of blood urea nitrogen, creatinine, fasting glucose, albumin, total cholesterol, triglyceride, total calcium, and phosphorus were measured using an autoanalyzer (Siemens Advia 1800, Siemens Healthcare GmbH, Henkestr, Germany) [ 16 17 ]. Serum adiponectin (SPI-BIO, Montigny le Bretonneux, France) and intact parathyroid hormone (iPTH) levels (Diagnostic Systems Laboratories, Texas, USA) were measured using a commercially available enzyme immunoassay or enzyme-linked immunosorbent assays, respectively [ 18 19 ].…”

Section: Aterials and Methodsmentioning

confidence: 99%

“…cfPWVs were measured transcutaneously by recording the pressure pulse waveform in the underlying artery using applanation tonometry (SphygmoCor system, AtCor Medical, Australia) as described [ 18 19 ]. These measurements were taken in the morning with patients in the supine position after a rest of at least 10 min in a quiet and temperature controlled room.…”

Section: Aterials and Methodsmentioning

confidence: 99%

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Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis

et al. 2020

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Objective: Adiponectin has antidiabetic, anti-atherosclerotic, and anti-inflammatory functions and protects against vascular damage. Carotid-femoral pulse wave velocity (cfPWV) is a noninvasive method for measuring central artery stiffness, which is known to be associated with cardiovascular disease in peritoneal dialysis (PD) patients. This study was conducted to evaluate the relationship between central arterial stiffness and serum adiponectin levels in PD patients. Materials and Methods: Fasting blood samples were obtained from 60 PD patients, and the cfPWV value was measured using a validated tonometry system. In this study, cfPWV values of >10 m/s were used to define the high arterial stiffness group according to the European Society of Hypertension and the European Society of Cardiology guidelines. Results: Among 60 patients with PD, 19 patients (31.7%) were included in the high arterial stiffness group. When compared to those in the control group, the high arterial stiffness group patients were older ( P = 0.029), had longer PD vintage ( P = 0.001), higher diastolic blood pressures ( P = 0.030), higher fasting glucose ( P = 0.014), and lower serum adiponectin levels ( P = 0.001). After multivariable logistic regression analysis, serum adiponectin (odds ratio, 0.612; 95% confidence interval: 0.426–0.879; P = 0.008) was identified as an independent predictor of arterial stiffness. The multivariable regression analysis also showed that the adiponectin level (β = −0.408; adjusted R 2 change = 0.183; P < 0.001) was negatively associated with cfPWV values in patients undergoing PD. Conclusion: Low serum adiponectin level is an independent marker of arterial stiffness in patients undergoing PD.

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Section: Discussionmentioning

confidence: 99%

Section: Aterials and Methodsmentioning

confidence: 99%

Section: Aterials and Methodsmentioning

confidence: 99%

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Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis

et al. 2020

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“…We used a single-frequency (50 kHz) analyzer to measure whole-body bioimpedances (hand–foot) of the fat mass on the basis of the standard tetrapolar (Biodynamic-450, Biodynamics Corporation, Seattle, USA). Same operator obtained all the measurements [12,13,16,17].…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, increased AS is a crucial predictor of the development of cardiovascular disease and mortality in type 2 DM patients [11]. Recent studies have suggested that low circulating adiponectin levels are associated with aortic AS in patients undergoing kidney transplantation or hemodialysis, in those with chronic kidney disease, and in young normotensive type 1 DM patients [12,13,14,15]. However, the association between aortic AS and serum adiponectin levels remains unknown in type 2 DM patients.…”

Section: Introductionmentioning

confidence: 99%

Association of Low Serum Adiponectin Levels with Aortic Arterial Stiffness in Patients with Type 2 Diabetes

Shih

Hsu

Hou

et al. 2019

JCM

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Adiponectin, an anti-inflammatory and anti-atherogenic protein, affects glucose metabolism. High serum adiponectin levels are associated with decreased diabetes mellitus (DM) risks. Aortic arterial stiffness (AS) is associated with cardiovascular disease and mortality in type 2 DM patients. We assessed the association between adiponectin levels and aortic AS in type 2 DM patients. We measured serum adiponectin levels in 140 volunteers with type 2 DM and assigned patients with carotid–femoral pulse wave velocity (cfPWV) >10 m/s to the aortic AS group (n = 54, 38.6%). These patients had higher systolic (p = 0.001) and diastolic (p = 0.010) blood pressures; body fat masses (p = 0.041); serum triglyceride (p = 0.026), phosphorus (p = 0.037), and insulin (p = 0.040) levels; and homeostasis model assessment of insulin resistance values (p = 0.029) and lower estimated glomerular filtration rates (p = 0.009) and serum adiponectin levels (p = 0.001) than controls. Multivariable logistic regression analysis adjusted for confounders showed serum adiponectin levels (OR 0.922; 95% CI, 0.876–0.970; p = 0.002) as an independent predictor of aortic AS. Multivariable forward stepwise linear regression analyses showed that serum adiponectin levels (β = −0.283, adjusted R2 change: 0.054, p < 0.001) were negatively associated with cfPWV. Thus, serum adiponectin level is an independent predictor of aortic AS in type 2 DM patients.

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Serum cystatin C is independently associated with aortic arterial stiffness in patients with type 2 diabetes

Lee

et al. 2018

Clinica Chimica Acta

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Serum adiponectin is a negative predictor of central arterial stiffness in kidney transplant patients

Abstract: Our study suggests that fasting serum adiponectin is negatively associated with carotid-femoral pulse wave velocity, hence arterial stiffness, in kidney transplant patients.

Cited by 7 publications

References 32 publications

Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis

Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis

Association of Low Serum Adiponectin Levels with Aortic Arterial Stiffness in Patients with Type 2 Diabetes

Serum cystatin C is independently associated with aortic arterial stiffness in patients with type 2 diabetes

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