Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures

Abstract

<jats:p> Proinflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of febrile seizures (FS). Adipocytokines like interleukin 6 (IL-6), leptin, and adiponectin released from adipose tissue play a role in inflammation. This study aimed to assess the probable role of adipose tissue in children with FS. We measured serum IL-6, leptin, and adiponectin levels and evaluated clinical and laboratory findings in children with FS ( n = 32) and compared the results with the values of children of the same age with febrile illness without seizures (febrile control, FC; n = 26) and healthy control group (HC; n = 29). The serum levels of white blood cells, C-reactive protein, IL-6, leptin, and adiponectin were found to be significantly higher, while serum hemoglobin (Hb) levels were found to be significantly lower in FS and FC groups than in the HC group ( p &lt; 0.001). When we compared the FS with the FC group, the serum Hb levels were significantly lower in the FS group than those in the FC group ( p = 0.001). There was no significant difference between the FS and FC group with regard to the serum levels of these adipocytokines ( p &gt; 0.05). Our data showed that elevated levels of these adipocytokines as acute phase reactants in FS and FC groups did not contribute to the development of FS. </jats:p>

Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study

“…Similar to our results, a recent study by Güven et al [ 20 ] who evaluated serum adiponectin levels in Turkish children with febrile seizures. This research suggested that elevated levels of serum adiponectin was an acute phase reactants in FS and FC groups that did not contribute to the development of FS.…”

Acute Phase Serum Leptin, Adiponectin, Interleukin-6, and Visfatin Are Altered in Chinese Children With Febrile Seizures: A Cross-Sectional Study

“…The earliest article on the relationship between FS and leptin published by Korean scholars reported that there was no difference in serum leptin levels between the FS group and the normal control. Güven et al (11) later found that the leptin levels in the FS and FC groups were higher than those in the normal control group, while the study by Seham (12) showed that the leptin levels in the FS group were lower than those in the normal control group, but the leptin levels in the FC group were significantly higher than in the HC group. Here, we found that the leptin and visfatin levels in the FS and FC groups were significantly lower than those in the normal control group, but there was no statistical difference between the FS and FC groups.…”

“…In Güven's study, information about antipyretics is not provided. In addition, it should be noted that the age of previous studies (8,(11)(12)(13) is <3-years-old. In this study, the age range is large, and there is no difference in the number of children over 3 years old and children under 3 years old.…”

Generation of Febrile Seizures and Subsequent Epileptogenesis

“…In particular, studies have been focused on the pro-inflammatory cytokines released both peripherally and centrally during fever. For example, interleukin-1 beta (IL-1b) [8][9][10], tumor necrosis factor alpha (TNFa), interleukin-1 alpha (IL-1a) and IL-6 [11] increase during FSs not only in animals but also in patients. However, which is dominant among these cytokines during FSs?…”