Serum adiponectin levels and enzyme markers of liver dysfunction in diabetic and non-diabetic Caribbean subjects

Ezenwaka, Chidum E.; Kalloo, Risha; Uhlig, Mathias; Schwenk, Robert W.; Eckel, Jürgen

doi:10.1080/09674845.2006.11732735

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…The data showed that insulin levels decreased in GDM compare with those in the GC group, but significant difference was only observed in the GDM-N group. Several studies previously reported contradictory results regarding the regulation trend of insulin secretion in GDM when defects in β-cell function are present (22,23). In comparison with the GC group, the present study analysed the insulin levels in GDM-M and found no significant difference but, the GDM-M group revealed a negative correlation between maternal serum insulin level and HDL level.…”

Section: Discussioncontrasting

confidence: 65%

“…Studies have been performed either on non-pregnant subjects or on male subjects, which showed a negative correlation between ALT and adiponectin levels (45,46). In another previous study, which analysed serum adiponectin levels and enzyme markers of liver dysfunction in both type 2 diabetic and non-diabetic Caribbean non-pregnant women, it did not identify any significant correlation between adiponectin and ALT in either group of patients (22). In the present analysis, only in the GDM-N group did the adiponectin levels in the third trimester correlate positively with AST, whilst maternal serum levels of AST and ALT were not modified by the GDM status with or without macrosomia.…”

Section: Discussionmentioning

confidence: 99%

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New born macrosomia in gestational diabetes mellitus

Bernea¹,

Uyy²,

Mihai³

et al. 2022

Exp Ther Med

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Gestational diabetes mellitus (GDM) is a metabolic complication of pregnancy. The pathogenesis of GDM is considered to involve β-cell dysfunction and insulin resistance (IR). GDM is associated with a significant risk of macrosomia in addition to a high probability of metabolic complications for the offspring. The precise mechanism underlying GDM remains unclear. The aim of the present study was to analyse the factors associated with insulin resistance and β-cell dysfunction involved in the pathophysiology of GDM complicated with macrosomia compared with GDM without macrosomia. In addition, another aim of the present study was to assess the relationship between GDM complicated with macrosomia and anthropometric, clinical and paraclinical parameters. The following group of patients were recruited as part of a case-control study: Patients with GDM without macrosomia, patients with GDM complicated with macrosomia and healthy gestational controls. Blood samples were collected at the third trimester of pregnancy and tested for adiponectin, leptin, insulin, proinsulin and C-peptide. Homeostatic model assessment-IR (HOMA-IR), steady state β-cell function (HOMA%B), insulin sensitivity (HOMA%S) and body mass index (BMI) were also calculated. All patients diagnosed with GDM showed an impairment in HOMA%B and a decrease in C-peptide maternal serum concentration. Additionally, diabetic status leading to the birth of offspring with macrosomia did not induce changes in the maternal serum levels of insulin, proinsulin, adiponectin or leptin, which was also the case in patients with GDM but not macrosomia. HOMA%B presented a stronger positive correlation with pre-pregnancy BMI and maternal weight gain, and a stronger negative correlation with adiponectin. Furthermore, HOMA%S in this group exhibited strong positive correlations with maternal serum levels of high-density lipoprotein cholesterol (HDL) and aspartate aminotransferase, and a strong negative correlation with pre-pregnancy BMI. In the same patients, HOMA-IR was also found to have a high negative correlation with HDL levels, and highly positive correlations with gestational age and triglyceride levels. In conclusion, the present study suggests that the different correlations among the factors involved in the pathogenesis of GDM may explain the evolution of GDM pregnancy to macrosomia.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

New born macrosomia in gestational diabetes mellitus

Bernea¹,

Uyy²,

Mihai³

et al. 2022

Exp Ther Med

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Relationship between adiponectin, inflammatory markers and obesity in Type 2 diabetic and non-diabetic Trinidadians

Nayak

Soon

Kunjal

et al. 2009

Archives of Physiology and Biochemistry

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Reevaluating Adiponectin’s impact on obesity hypertension: a Chinese case-control study

Wu,

Lu,

Leng

et al. 2024

BMC Cardiovasc Disord

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Background Obesity and hypertension are major risk factors for cardiovascular diseases that affect millions of people worldwide. Both conditions are associated with chronic low-grade inflammation, which is mediated by adipokines such as adiponectin. Adiponectin is the most abundant adipokine that has a beneficial impact on metabolic and vascular biology, while high serum concentrations are associated with some syndromes. This “adiponectin paradox” still needs to be clarified in obesity-associated hypertension. The aim of this study was to investigate how adiponectin affects blood pressure, inflammation, and metabolic function in obesity hypertension using a Chinese adult case-control study. Methods A case-control study that had finished recruiting 153 subjects divided as four characteristic groups. Adiponectin serum levels were tested by ELISA in these subjects among these four characteristic Chinese adult physical examination groups. Waist circumference (WC), body mass index (BMI), systolic blood pressure (SB), diastolic blood pressure (DB), and other clinical laboratory data were collected. Analyzation of correlations between the research index and differences between groups was done by SPSS. Results Serum adiponectin levels in the| normal healthy group (NH group) were significantly higher than those in the newly diagnosed untreated just-obesity group (JO group), and negatively correlated with the visceral adiposity index. With multiple linear egression analysis, it was found that, for serum adiponectin, gender, serum albumin (ALB), alanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDLC) were the significant independent correlates, and for SB, age and HDLC were the significant independent correlates, and for DB, alkaline phosphatase (ALP) was the significant independent correlate. The other variables did not reach significance in the model. Conclusions Our study reveals that adiponectin’s role in obesity-hypertension is multifaceted and is influenced by the systemic metabolic homeostasis signaling axis. In obesity-related hypertension, compensatory effects, adiponectin resistance, and reduced adiponectin clearance from impaired kidneys and liver all contribute to the “adiponectin paradox”.

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Serum adiponectin levels and enzyme markers of liver dysfunction in diabetic and non-diabetic Caribbean subjects

Cited by 3 publications

References 24 publications

New born macrosomia in gestational diabetes mellitus

New born macrosomia in gestational diabetes mellitus

Relationship between adiponectin, inflammatory markers and obesity in Type 2 diabetic and non-diabetic Trinidadians

Reevaluating Adiponectin’s impact on obesity hypertension: a Chinese case-control study

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