Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients

Silva, Débora M.; Queiroz, Nayara Pedatella; Freitas, Ana Tereza Vaz de Souza; Passarelli, Marisa; Corgosinho, Flávia Campos; Peixoto, Maria do Rosário Gondim

doi:10.1038/s41430-018-0379-4

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Indeed, our final regression model suggests an inverse relationship between trunk fat mass content and AGE, while at the same time, there is a reciprocal relationship between the percentage of skeletal muscle and AGE in Dalmatian KTRs. A study from Calvino on 189 stable KTRs found negative correlations between SAF-measured AGE and dynamometry [ 7 ], and the results from Silva et al [ 59 ] found no associations between AGE and muscle strength in HD patients, while our results suggest differently, suggesting that skeletal muscle mass percentage is a positive predictor of AGE in KTRs. In a prospective cohort study of 592 healthy volunteers by Semba et al, fat mass was inversely associated with serum carboxymethyl lysine, a major circulating AGE, considering the possibility that AGE is stored in adipose tissue [ 28 ].…”

Section: Discussionsupporting

confidence: 48%

Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients

Radić

Vučković

Gelemanović

et al. 2022

IJERPH

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There is limited evidence on the associations between dietary patterns, body composition, and nonclassical predictors of worse outcomes such as advanced glycation end products (AGE) in kidney transplant recipients (KTRs). The aim of this cross-sectional study was to determine the level of AGE-determined cardiovascular (CV) risk in Dalmatian KTRs and possible associations between AGE, adherence to the Mediterranean diet (MeDi), and nutritional status. Eighty-five (85) KTRs were enrolled in this study. For each study participant, data were collected on the level of AGE, as measured by skin autofluorescence (SAF), Mediterranean Diet Serving Score (MDSS), body mass composition, anthropometric parameters, and clinical and laboratory parameters. Only 11.76% of the participants were adherent to the MeDi. Sixty-nine percent (69%) of KTRs had severe CV risk based on AGE, while 31% of KTRs had mild to moderate CV risk. The results of the LASSO regression analysis showed that age, dialysis type, dialysis vintage, presence of CV and chronic kidney disease, C- reactive protein level, urate level, percentage of muscle mass, and adherence to recommendations for nuts, meat, and sweets were identified as positive predictors of AGE. The negative predictors for AGE were calcium, phosphate, cereal adherence according to the MeDi, and trunk fat mass. These results demonstrate extremely low adherence to the MeDi and high AGE levels related CV risk in Dalmatian KTRs. Lifestyle interventions in terms of CV risk management and adherence to the MeDi of KTRs should be taken into consideration when taking care of this patient population.

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Section: Discussionsupporting

confidence: 48%

Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients

Radić

Vučković

Gelemanović

et al. 2022

IJERPH

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“…Five studies reported performing HGS during dialysis, particularly during the mid-week session [42,58] and within the first hour [37,59]. There is limited evidence on how HGS results could be influenced by the dialysis session itself (and events that can occur such as hypotension) [85].…”

Section: Discussionmentioning

confidence: 99%

“…Eighteen studies reported assessments before dialysis, with Bogataj et al [57] stating this should be at least 30-minutes before. Five studies reported performing HGS during dialysis, particularly during the mid-week session [42,58] and within the first hour of dialysis [37,59].…”

Section: Testing Timementioning

confidence: 99%

A Systematic Review of Handgrip Strength Measurement in Clinical and Epidemiological Studies of Kidney Disease: Toward a Standardized Approach

Wilkinson

Gabrys

Lightfoot

et al. 2022

Journal of Renal Nutrition

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“…The measurement was performed three times with an interval of 1 min. For the analysis, the highest value obtained was considered [ 22 , 23 ]. The cutoff points used for low muscle strength were HGS < 16 kg for women and < 27 kg for men [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

The relationship between grip strength with health-related quality of life and mortality in hemodialysis patients

Sugizaki

Rodrigues

Ivo

et al. 2022

Nutrire

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Purpose Hemodialysis (HD) is a therapeutic modality that enables the highest survival for individuals with chronic kidney disease (CKD). In contrast, HD contributes to the pro-inflammatory state and may negatively affect the muscle strength and quality of life (QoL) of these individuals. To date, few studies have evaluated the association between decrease in strength and QoL in HD patients. Thus, our objective was to assess whether diminished muscle strength is associated with worse health related QoL and mortality. Methods We included patients aged ≥ 18 years on HD. Clinical and demographic data were collected from patients’ medical records. Clinical data, nutritional status (laboratory, anthropometry, bioimpedance analysis) and health-related QoL (World Health Organization’s quality of life questionnaire, WHOQOL-Bref) were analyzed at baseline. Mortality was recorded for 32 months. Results Among the 105 patients evaluated, the median age was 52 (43–64) years, and males were predominant (n = 73; 70%). The general median of QoL was 66.8 ± 11.9. Approximately 30% of patients were considered to have a worse QoL and 12,4% to have low muscle strength. This was not associated with QoL and mortality. HD vintage greater then to 5 years was associated with higher dissatisfaction in the perception of the environmental domain and overall QoL. Conclusion Our data suggest that low muscle strength was not associated with health-related QoL using the WHOQOL-Bref instrument and mortality.

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Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients

Cited by 3 publications

References 32 publications

Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients

Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients

A Systematic Review of Handgrip Strength Measurement in Clinical and Epidemiological Studies of Kidney Disease: Toward a Standardized Approach

The relationship between grip strength with health-related quality of life and mortality in hemodialysis patients

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