Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre‐eclampsia and eclampsia

Noyan, Tevfik; Güler, Ayşe; Şekeroğlu, Mehmet Ramazan; Kamacı, Mansur

doi:10.1111/j.1479-828x.2006.00647.x

Cited by 31 publications

(19 citation statements)

References 43 publications

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“…In contrast to results of lipid damage, protein oxidation levels, measured as AOPP, seem to be dependent only on the NO x concentration in sheep (P < 0.05), whereas neither NO x nor TOS seem to depict the protein damage in goats (P > 0.05), in which protein oxidation levels are related only with OSI (P < 0.05). The lack of correlation with the investigated oxidative substances in goats may suggest that neither NO x nor TOS are useful to describe protein damage measured as AOPP, arisen from the reaction between plasma proteins and chlorinated oxidants mediated by a neutrophil enzyme myeloperoxidase (Noyan et al, 2006). Thus, it can be assumed that other OS biomarkers may be used to better describe the protein oxidation damage or to more easily correlate with this parameter.…”

Section: Resultsmentioning

confidence: 99%

Redox status, and lipid peroxidation and protein oxidation levels in small ruminants

Gualandi¹,

Piccione²,

Saoca³

et al. 2018

J. Anim. Feed Sci.

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Section: Resultsmentioning

confidence: 99%

Redox status, and lipid peroxidation and protein oxidation levels in small ruminants

Gualandi¹,

Piccione²,

Saoca³

et al. 2018

J. Anim. Feed Sci.

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“…Activated neutrophils produce ROS (O 2 ⅐ Ϫ and H 2 O 2 ) via NADPH oxidase as part of their antipathogen response. MPO, a major granule enzyme in neutrophils, accounts for 5% of the total neutrophil protein and is responsible for the production of HOCl oxidant (28). The release of ROS and HOCl by neutrophils may cause damage to important biological structures, such as proteins, carbohydrates, lipids, and nucleic acids, and may enhance inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Increased Myeloperoxidase Activity and Protein Nitration Are Indicators of Inflammation in Patients with Chagas' Disease

Dhiman

Estrada-Franco

Pando

et al. 2009

Clin Vaccine Immunol

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In this study, we investigated whether inflammatory responses contribute to oxidative/nitrosative stress in patients with Chagas' disease. We used three tests (enzyme-linked immunosorbent assay, immuno-flow cytometry, and STAT-PAK immunochromatography) to screen human serum samples (n ‫؍‬ 1,481) originating from Chiapas, Mexico, for Trypanosoma cruzi-specific antibodies. We identified 121 subjects who were seropositive for T. cruzi-specific antibodies, a finding indicative of an 8.5% seroprevalence in the rural population from Chiapas. Seropositive and seronegative subjects were examined for plasma levels of biomarkers of inflammation, i.e., myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS), and xanthine oxidase (XOD), as well as for oxidative (advanced oxidation protein products [AOPPs]) and nitrosative (3-nitrotyrosine [3NT]) biomarkers. The seropositive subjects exhibited a significant increase in MPO activity and protein level, the indicator of neutrophil activation. Subsequently, a corresponding increase in AOPP contents, formed by MPO-dependent hypochlorous acid and chloramine formation, was noted in seropositive subjects. The plasma level of 3NT was significantly increased in seropositive subjects, yet we observed no change in XOD activity (O 2 ⅐ ؊ source) and nitrate/nitrite contents (denotes iNOS activation and ⅐ NO production), which implied that direct peroxynitrite formation does not contribute to increased nitrosative damage in chagasic subjects. Instead, a positive correlation between increased MPO activity and protein 3NT formation was observed, which suggested to us that MPO-dependent formation of nitrylchloride that occurs in the presence of physiological ⅐ NO and O 2 ⅐ ؊ concentrations contributes to protein nitration. Overall, our data demonstrate that T. cruzi-induced neutrophil activation is pathological and contributes to MPO-mediated collateral protein oxidative and nitrosative damage in human patients with Chagas' disease. Therapies capable of suppressing MPO activity may be useful in controlling the inflammation and oxidative/nitrosative pathology in chagasic cardiomyopathy.

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“…We hypothesized that increased levels of AOPP may reflect oxidative damage to proteins associated with the development of endothelial dysfunction. As there is limited data describing AOPP levels in pregnancy we also recruited a control group of non-pregnant women to aid interpretation of results [29,30] . Whilst AOPP levels appear to be increased in pregnancy, there was no statistical difference between levels in women who remained normotensive or became preeclamptic in later pregnancy, findings similar to those of Fialova et al [12] .…”

Section: Discussionmentioning

confidence: 99%

Maternal Plasma Fibronectin and Advanced Oxidative Protein Products for the Prediction of Preeclampsia in High Risk Pregnancies: A Prospective Cohort Study

Dane¹,

Buyukasik²,

Dane³

et al. 2009

Fetal Diagn Ther

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Objective: To determine whether maternal plasma fibronectin and advanced oxidative protein products (AOPP) can be used for the prediction of preeclampsia in high-risk women. Study Design: One hundred pregnant women at high risk of preeclampsia were enrolled in this prospective cohort study. Maternal plasma total fibronectin and AOPP levels were measured at 19–25 weeks of gestation. AOPP levels were also measured in 23 normal non-pregnant women. After delivery, the pregnant cohort was assigned to either the normotensive or preeclamptic group depending on their clinical course. Results: Among the 78 pregnant women who completed the study, 19 (24.3%) developed preeclampsia between 36 and 39 (36.8 ± 1.0) weeks of gestation. AOPP levels, which are significantly higher in normotensive pregnant women compared to nonpregnant controls (42.55 ± 15.94 vs. 27.95 ± 10.5; p = 0.0001) were not significantly different between normotensive and preeclamptic women (42.55 ± 15.94 vs. 47.45 ± 14.19 μM; p = 0.23). Plasma fibronectin levels were significantly higher in women who continued to develop preeclampsia rather than remain normotensive (383.68 ± 19.07 vs. 227.65 ± 97.39; p < 0.0001). ROC curve analysis shows that total fibronectin ≥360 mg/l is predictive for the development of preeclampsia. The sensitivity, specificity, positive and negative predictive values are 57, 92, 73 and 85%, respectively, with a likelihood ratio of 7.38. Conclusion: Second trimester plasma concentrations of AOPP are not altered in women that develop pre-eclampsia later in pregnancy. However, total fibronectin levels are significantly increased and may be used to predict the onset of clinical symptoms of preeclampsia.

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Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre‐eclampsia and eclampsia

Abstract: We suggest that increased oxidative stress might contribute to the pathophysiological mechanisms of pre-eclampsia and eclampsia, and that AA and CAT might have a protective role via free radical-scavenging properties. However, further study is needed.

Cited by 31 publications

References 43 publications

Redox status, and lipid peroxidation and protein oxidation levels in small ruminants

Redox status, and lipid peroxidation and protein oxidation levels in small ruminants

Increased Myeloperoxidase Activity and Protein Nitration Are Indicators of Inflammation in Patients with Chagas' Disease

Maternal Plasma Fibronectin and Advanced Oxidative Protein Products for the Prediction of Preeclampsia in High Risk Pregnancies: A Prospective Cohort Study

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