Serum AGE-elastin derived peptides among diabetic children

Nicoloff, G.; Николов, А; Dekov, D.

doi:10.1016/j.vph.2005.03.007

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Increased MMP plasma concentrations, such as MMP-2 and MMP-9, 85 and serum levels of EDP and glycated EDP have been reported in diabetic patients. 64,86,87 Indeed, the presence of EDP in the blood leads to the formation of anti-elastin antibodies, and both are associated with the development of diabetic vascular complications. 64,86 -89 How elastin fragmentation and EDP contribute to the development of diabetes mellitus and/or vascular complications associated with diabetes mellitus remains unknown so far.…”

Section: Pathophysiological Consequences Of Elastin Remodelling Durinmentioning

confidence: 99%

Matrix ageing and vascular impacts: focus on elastin fragmentation

et al. 2016

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications.

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Section: Pathophysiological Consequences Of Elastin Remodelling Durinmentioning

confidence: 99%

Matrix ageing and vascular impacts: focus on elastin fragmentation

et al. 2016

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“…The prevalence of microalbuminuria in patients with T2DM is a sensetive predictor of future development of diabetic nephropathy. Microalbuminuria not only implies the presence of renal involvment in diabetes, but is also associated with generalized vascular damage Nikolov [ 16 ]. Increased synthesis or increased degradation could cause the elevated serum levels of CIV which are strong pathological stimulus for production of specific antibodies found in our study, mainly in patients with microalbuminuria.…”

Section: Discussionmentioning

confidence: 99%

Serum anti-collagen type IV IgM antibodies and development of diabetic nephropathy in diabetics with essential hypertension

Николов

Tsinlikov

Tsinlikova

et al. 2016

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Introduction and aimsArterial hypertension and diabetic vascular complications are connected with an elevated degradation of elastic tissue. This process leads to an increased production of antibodies to collagen type IV (ACIV Abs). In the present investigation we studied whether the serum levels of antibodies (IgG, IgM and IgA) to collagen are related with microvascular complications.Material and methodsSerum levels of antibodies to collagen type IV (ACIV) IgG, IgM and IgA were measured using an ELISA method in 93 patients with type 2 diabetes mellitus and arterial hypertension (AH) (mean age 61.4 ±11.3 years, diabetes duration 9.88 ±3.12 years; hypertension duration 9.28 ±4.98). These values were compared to serum antibodies to CIV in 42 age and sex matched controls.ResultsACIV IgM antibodies levels in patients with AH and T2DM were statisticaly significantly higher than controls 0.178 (0.145÷0.220) vs. 0.142 (0.118÷0.173) (KW = 6.31; p = 0.01). Group 1 (patients with microvascular complications) showed significantly higher levels of ACIV IgM than controls 0.180 (0.136÷0.223) vs. 0.142 (0.118÷0.173) (KW = 5.03; p = 0.02). Patients from Group 2 showed statistically significantly higher levels of ACIV IgM than controls 0.176 (0.151÷0.202) vs. 0.142 (0.118÷0.173) (KW = 6.15; p = 0.01). ACIV IgM antibodies showed correlation with microalbuminuria (r = 0.21); (p = 0.04), BMI (r = 0.19); (p = 0.04), creatinine clearance (r = –0.36); (p = 0.01) and GFR (r = –0.34); (p = 0.02).ConclusionsOur study showed an association between elevation of serum levels of ACIV IgM and development of diabetic nephropathy. We suggest that levels of ACIV IgM can be useful method for identfying a high risk for development of diabetic nephropathy.

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“…The markers that allow insights into elastin and collagen metabolism are important for connective-tissue turnover. The relationships of biological markers of extracellular matrix (plasma elastin and collagen peptides, elastin and collagen antibodies, elastase enzymes, and elastase inhibitors) to the clinical history of cardiovascular diseases and risk factors for atherosclerosis were examined by Baydanoff et al (1987), Gminski et al (1991), Bizbiz et al (1996Bizbiz et al ( , 1997, Nicoloff et al (2000Nicoloff et al ( , 2001Nicoloff et al ( , 2002Nicoloff et al ( , 2005b, and Colburn et al (2003).…”

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confidence: 99%

Serum cobalt in children with essential hypertension

et al. 2006

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The effect of cobalt on the cardiovascular system is one of many aspects of cobalt metabolism in humans. Elastin and collagen are the main proteins of the vascular wall. The aims of this study were: 1) to determine serum cobalt concentrations in children with hypertension; and 2) to study the correlation between serum cobalt and some biological markers of the extracellular matrix of the vascular wall, i.e., anti-elastin and anti-collagen type IV antibodies. Patients showed statistically significant higher levels of systolic and diastolic blood pressure, and significantly lower serum cobalt concentrations, than controls. Children with hypertension showed significantly higher levels of total cholesterol (P = 0.0003) and collagen type IV IgM (P = 0.04). Collagen type IV IgG levels (P = 0.027) were lower than in controls. Serum cobalt in patients showed a correlation with systolic blood pressure (r = -0.44, P = 0.05), elastin IgM (r = 0.60, P = 0.007), and collagen type IV IgG (r = -0.46, P = 0.04). Our data suggest the existence of a correlation between changes in levels of serum cobalt, total cholesterol, anti-collagen type IV antibodies, and essential hypertension in children. This is the first study of serum cobalt in children with essential hypertension.

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Serum AGE-elastin derived peptides among diabetic children

Cited by 6 publications

References 32 publications

Matrix ageing and vascular impacts: focus on elastin fragmentation

Matrix ageing and vascular impacts: focus on elastin fragmentation

Serum anti-collagen type IV IgM antibodies and development of diabetic nephropathy in diabetics with essential hypertension

Serum cobalt in children with essential hypertension

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