Serum amyloid A as a prognostic marker in cats with various diseases

Tamamoto, Takashi; Ohno, Koichi; Takahashi, Masashi; Nakashima, Ko; Fujino, Yasuhito; Tsujimoto, Hajime

doi:10.1177/1040638713486112

Cited by 54 publications

(63 citation statements)

References 16 publications

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“…8,41,42 Furthermore, development of an APP response and of oxidative stress were previously described in human breast cancer and in canine mammary tumours. [21][22][23][24][25][26] APP and parameters of oxidative status were also proved to be clinically useful biomarkers in feline oncologic diseases, [43][44][45] however, to the best of our knowledge, this is the first study to comprehensively evaluate the APP and the antioxidant responses of feline spontaneous malignant mammary tumours.…”

Section: Discussionmentioning

confidence: 99%

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Vilhena

Tvarijonaviciute

Cerón

et al. 2019

Vet Comparative Oncology

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Acute phase proteins (APP) and biomarkers of oxidative status change in human and canine mammary tumours, however, they have not been studied in feline mammary tumours. The aims of this study were to investigate the APP and antioxidant responses in feline malignant mammary tumours, to evaluate their relation with tumour features, and to assess their prognostic value. Serum amyloid A (SAA), haptoglobin (Hp), albumin, butyrylcholinesterase (BChE), insulin‐like growth factor1 (IGF1), paraoxonase1 (PON1), total serum thiols (Thiol), glutathione peroxidase (GPox) and total antioxidant capacity determined by different assays, including trolox equivalent antioxidant capacity assessed by two different methodologies (TEAC1/2), ferric reducing ability of plasma (FRAP), and cupric reducing antioxidant capacity (CUPRAC), were determined in serum of 50 queens with spontaneous mammary carcinomas and of 12 healthy female cats. At diagnosis, diseased queens presented significantly higher SAA and Hp, and lower albumin, BChE, GPox, TEAC1, TEAC2 and CUPRAC than controls. Different tumour features influenced concentrations of APP and antioxidants. Increases in serum Hp, and decreases in albumin, Thiol and FRAP were significantly associated with neoplastic vascular emboli, metastasis in regional lymph nodes and/or in distant organs. Distant metastasis development during the course of the disease was associated with increases in SAA and TEAC1. At diagnosis, decreased albumin was associated with a longer survival, and BChE <1.15 μmoL/mL.minute was associated with a shorter survival time on multivariate analysis. Feline malignant mammary tumours are associated with an APP response and oxidative stress, and different tumour features influence the inflammatory response and the oxidative damage. Furthermore, some of these analytes proved to have prognostic value.

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Section: Discussionmentioning

confidence: 99%

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Vilhena

Tvarijonaviciute

Cerón

et al. 2019

Vet Comparative Oncology

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“…In addition, AGP in cat serum or effusion samples is a recognised biomarker of FIP (6,21,25). However, these APP concentrations increase not only in inflammatory diseases, but also in several non-inflammatory disorders, such as neoplasia, diabetes mellitus and hyperthyroidism (10,22,27). In the present study, changes in APPs in cats with anaemia were investigated.…”

Section: Methodsmentioning

confidence: 99%

“…Measurement of SAA and AGP concentrations are considered useful in detecting the presence of inflammation (17,26,27). In addition, AGP in cat serum or effusion samples is a recognised biomarker of FIP (6,21,25).…”

Section: Methodsmentioning

confidence: 99%

Serum concentrations of some acute phase proteins in cats with anaemia

Tuna¹,

Dinler²,

̃ici³

et al. 2018

Medycyna Weterynaryjna

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SummarySerum concentrations of acute phase proteins can provide valuable diagnostic information in the detection and monitoring of disease. The available information on the acute phase response in cats with anaemia is limited. The aim of this study was to retrospectively evaluate serum concentrations of haptoglobin, serum amyloid A, α1 acid glycoprotein and their clinical importance in cats with anaemia. Thirty-four anaemic cats and ten healthy cats were enrolled this study. After individual diagnoses had been established, the cats were divided into three groups (healthy group, haemolytic group and non-haemolytic group). Serum acute phase protein concentrations were analysed using specific commercially available test kits in an ELISA reader device. Serum amyloid A and serum α1 acid glycoprotein concentrations were significantly higher in the anaemic groups compared with the healthy group. Haptoglobin concentrations were significantly higher in cats from the non-haemolytic anaemia group than they were in healthy animals and those from the haemolytic anaemia group. Although serum haptoglobin concentrations were lower than in the healthy group, there was no significant difference between the haemolytic anaemia group and the healthy group. The results of this study suggest that serum amyloid A and α1 acid glycoprotein could be useful in the diagnosis and determination of inflammation in cats with anaemia. Serum haptoglobin depletion may be used for diagnosis of haemolysis in cats with haemolytic anaemia. In addition, this study has contributed to the limited data available on acute phase protein concentrations in cats with anaemia.

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“…Moreover, a study suggested that the median survival time of cats with elevated SAA levels (>0.82 mg/L) was signifi cantly shorter in various diseases, including FIP [8].…”

Section: Catsmentioning

confidence: 99%

“…Recently, this protein has been investigated as a signifi cant prognostic marker and as a useful predictive indicator of prognosis in various diseases [7][8][9][10]. An isoform of SAA (SAA-2) is involved in reactive amyloidosis and other chronic infl ammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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Serum amyloid A as a prognostic marker in cats with various diseases

Cited by 54 publications

References 16 publications

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Serum concentrations of some acute phase proteins in cats with anaemia

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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