Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer

Lee, Vivian; Beatty, Gregory L.

doi:10.3390/cancers13133179

Cited by 16 publications

(15 citation statements)

References 141 publications

(176 reference statements)

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“…SAA is a substance synthesized and induced by tumor necrosis factor, interleukin −1 and interleukin −6. When the body is stimulated by inflammation or infection, the serum levels of SAA can increase abnormally ( 26 ). Davis’ team reported that the progress and metastasis of CRC are closely associated with inflammatory response ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Expression and Predictive Value of Serum NLR, PLR Combined with SAA in Patients with Different Stages of Colorectal Cancer

Yang¹,

Sun

Zhao

2022

Front. Surg.

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Colorectal cancer (CRC) is one of the major causes of death in the world, and has become a serious threat to human life. The prognosis of CRC patients in different pathological stages is quite different, so it is necessary to evaluate the clinical stages of CRC patients before surgery. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), serum amyloid A (SAA) and other indicators have been widely proved to play the role of early diagnosis and prognosis monitoring in chronic inflammatory diseases and cancers. In this study, we collected clinical data of 103 patients with CRC confirmed by pathology in Yiwu Central Hospital from January 2019 to December 2021. In addition, it aims to explore the expression and predictive value of NLR, PLR combined with SAA in patients with different stages of CRC, so as to provide reference for patients to choose a reasonable treatment plan. The results show that serum NLR, PLR combined with SAA can predict CRC staging effectively, which has certain auxiliary value for clinical decision-making.

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Section: Discussionmentioning

confidence: 99%

Expression and Predictive Value of Serum NLR, PLR Combined with SAA in Patients with Different Stages of Colorectal Cancer

Yang¹,

Sun

Zhao

2022

Front. Surg.

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“…The amyloid proteins SAA are positively correlated with the cancer stage in lung cancer, breast cancer and melanoma [ 58 , 59 , 60 , 61 ]. It was suggested that SAA may enhance cancer cell proliferation and migration through the regulation of inflammation [ 62 , 63 ]. The amyloid protein S100A9, which is one of key factors promoting neuroinflammation [ 64 ], plays a role in prostate cancer invasion and is associated with disease progression [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Human RAD51 Protein Forms Amyloid-like Aggregates In Vitro

Kachkin

Volkov

Sopova

et al. 2022

IJMS

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RAD51 is a central protein of homologous recombination and DNA repair processes that maintains genome stability and ensures the accurate repair of double-stranded breaks (DSBs). In this work, we assessed amyloid properties of RAD51 in vitro and in the bacterial curli-dependent amyloid generator (C-DAG) system. Resistance to ionic detergents, staining with amyloid-specific dyes, polarized microscopy, transmission electron microscopy (TEM), X-ray diffraction and other methods were used to evaluate the properties and structure of RAD51 aggregates. The purified human RAD51 protein formed detergent-resistant aggregates in vitro that had an unbranched cross-β fibrillar structure, which is typical for amyloids, and were stained with amyloid-specific dyes. Congo-red-stained RAD51 aggregates demonstrated birefringence under polarized light. RAD51 fibrils produced sharp circular X-ray reflections at 4.7 Å and 10 Å, demonstrating that they had a cross-β structure. Cytoplasmic aggregates of RAD51 were observed in cell cultures overexpressing RAD51. We demonstrated that a key protein that maintains genome stability, RAD51, has amyloid properties in vitro and in the C-DAG system and discussed the possible biological relevance of this observation.

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“…FPR2 can also trigger a pro-inflammatory pathway and the switch between FPR2-mediated pro- and anti-inflammatory cell responses depends on conformational changes of the receptor upon ligand binding [ 91 ]. Serum amyloid A proteins (SAAs) are acute-phase reactants secreted during responses to infection or injury and are elevated in the plasma and tumors of cancer patients [ 92 ]. SAAs can preferentially bind to FPR2 to promote IL-8 production by neutrophils [ 93 ] and SAAs act as a chemotactic signal enhancing neutrophil recruitment [ 94 ].…”

Section: Introductionmentioning

confidence: 99%

Intratumoral pro-oxidants promote cancer immunotherapy by recruiting and reprogramming neutrophils to eliminate tumors

Ralph

Reynolds²

2022

Cancer Immunol Immunother

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Neutrophils have recently gained recognition for their potential in the fight against cancer. Neutrophil plasticity between the N1 anti-tumor and N2 pro-tumor subtypes is now apparent, as is the ability to polarize these individual subtypes by interventions such as intratumoral injection of various agents including bacterial products or pro-oxidants. Metabolic responses and the production of reactive oxygen species (ROS) such as hydrogen peroxide act as potent chemoattractants and activators of N1 neutrophils that facilitates their recruitment and ensuing activation of a toxic respiratory burst in tumors. Greater understanding of the precise mechanism of N1 neutrophil activation, recruitment and regulation is now needed to fully exploit their anti-tumor potential against cancers both locally and at distant sites. This systematic review critically analyzes these new developments in cancer immunotherapy.

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Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer

Cited by 16 publications

References 141 publications

Expression and Predictive Value of Serum NLR, PLR Combined with SAA in Patients with Different Stages of Colorectal Cancer

Expression and Predictive Value of Serum NLR, PLR Combined with SAA in Patients with Different Stages of Colorectal Cancer

Human RAD51 Protein Forms Amyloid-like Aggregates In Vitro

Intratumoral pro-oxidants promote cancer immunotherapy by recruiting and reprogramming neutrophils to eliminate tumors

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