Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages

Xi, Dan; Zhao, Jian; Guo, Kai; Hu, Lu; Chen, Hui; Fu, Weijun; Lai, Wenyan; Guo, Zhigang

doi:10.7150/thno.22704

Cited by 19 publications

(11 citation statements)

References 45 publications

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“…The amount of SAP in tissues increases in degenerative aortic stenosis; in addition, SAP levels in plasma are positively associated with cardiovascular diseases in the elderly [25]. In a study on apolipoprotein E-deficient (Apoe−/−) mice, intraperitoneal injection of SAP was shown to inhibit atherosclerosis in these animals [26], expression of SAP increased in hemorrhagic atherosclerotic plaques of carotid arteries, compared with fibrous plaques [16].…”

Section: Discussionmentioning

confidence: 99%

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis

et al. 2019

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Background: To study the changes in protein composition of atherosclerotic plaques at different stages of their development in coronary atherosclerosis using proteomics. Methods: The object of research consisted of homogenates of atherosclerotic plaques from coronary arteries at different stages of development, obtained from 15 patients. Plaque proteins were separated by two-dimensional electrophoresis. The resultant protein spots were identified by the matrix-assisted laser desorption ionization method with peptide mass mapping. Results: Groups of differentially expressed proteins, in which the amounts of proteins differed more than twofold (p < 0.05), were identified in pools of homogenates of atherosclerotic plaques at three stages of development. The amounts of the following proteins were increased in stable atherosclerotic plaques at the stage of lipidosis and fibrosis: vimentin, tropomyosin β-chain, actin, keratin, tubulin β-chain, microfibril-associated glycoprotein 4, serum amyloid P-component, and annexin 5. In plaques at the stage of fibrosis and calcification, the amounts of mimecan and fibrinogen were increased. In unstable atherosclerotic plaque of the necrotic–dystrophic type, the amounts of human serum albumin, mimecan, fibrinogen, serum amyloid P-component and annexin were increased. Conclusion: This proteomic study identifies the proteins present in atherosclerotic plaques of coronary arteries by comparing their proteomes at three different stages of plaque development during coronary atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis

et al. 2019

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“…CD209 activation by a synthetic ligand [ 53 ] can mimic SAP effects on neutrophils, monocytes, and macrophages [ 47 ]. SAP and a CD209 ligand can inhibit high fat diet-induced adipose tissue and liver inflammation and steatosis in mice, and SAP can inhibit high fat diet-induced atherosclerosis [ 54 , 55 ].…”

Section: Introductionmentioning

confidence: 99%

A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet

Pilling

Karhadkar

2020

PLoS ONE

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Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes and is characterized by the accumulation of fat in the liver (steatosis). NAFLD can transition into non-alcoholic steatohepatitis (NASH), with liver cell injury, inflammation, and an increased risk of fibrosis. We previously found that injections of either 1866, a synthetic ligand for the lectin receptor CD209, or DANA, a sialidase inhibitor, can inhibit inflammation and fibrosis in multiple animal models. The methionine and choline-deficient (MCD) diet is a model of NASH which results in the rapid induction of liver steatosis and inflammation. In this report, we show that for C57BL/6 mice on a MCD diet, injections of both 1866 and DANA reversed MCD diet-induced decreases in white fat, decreases in adipocyte size, and white fat inflammation. However, these effects were not observed in type 2 diabetic db/db mice on a MCD diet. In db/db mice on a MCD diet, 1866 decreased liver steatosis, but these effects were not observed in C57BL/6 mice. There was no correlation between the ability of 1866 or DANA to affect steatosis and the effects of these compounds on the density of liver macrophage cells expressing CLEC4F, CD64, F4/80, or Mac2. Together these results indicate that 1866 and DANA modulate adipocyte size and adipose tissue macrophage populations, that 1866 could be useful for modulating steatosis, and that changes in the local density of 4 different liver macrophages cell types do not correlate with effects on liver steatosis.

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“…In addition, the levels of SAP in plasma are positively associated with cardiovascular diseases in the elderly [60]. In a study on mouse models with apolipoprotein E deficiency (Apoe −/−), intraperitoneal injection of SAP inhibits atherosclerosis in these animals [61].…”

Section: Results Of Proteomic Studies Of Atherosclerotic Plaquesmentioning

confidence: 99%

Proteomic Studies of Blood and Vascular Wall in Atherosclerosis

Стахнева

Striukova

Ragino

2021

IJMS

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The review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research on the new proteomic potential biomarkers of coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, carotid artery atherosclerosis. Also, the analysis of literature data on proteomic studies of the vascular wall was carried out. To assess the involvement of proteins in the pathological process of atherosclerosis, it is important to investigate the specific relationships between proteins in the arteries, expression and concentration of proteins. The development of proteomic technologies has made it possible to analyse the number of proteins associated with the development of the disease. Analysis of the proteomic profile of the vascular wall in atherosclerosis can help to detect possible diagnostically significant protein structures or potential biomarkers of the disease and develop novel approaches to the diagnosis of atherosclerosis and its complications.

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Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages

Cited by 19 publications

References 45 publications

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis

A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet

Proteomic Studies of Blood and Vascular Wall in Atherosclerosis

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