Serum and Peritoneal Inflammatory Mediators in Children With Suspected Acute Appendicitis

Dalal, Ilan; Somekh, Eli; Bilker-Reich, Avital; Boaz, Mona; Gorenstein, Arkadi; Serour, Francis

doi:10.1001/archsurg.140.2.169

Cited by 43 publications

(34 citation statements)

References 21 publications

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“…There are little and controversial data about the use of G-CSF in AA diagnosis. Dalal et al reported that there is not any significant increase in levels of G-CSF in AA [9]. In contrast, Allister et al found that when compared to normal population, in AA G-CSF levels increase significantly [10].…”

Section: Discussionmentioning

confidence: 95%

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The Role of C-Reactive Protein, Granulocyte Colony Stimulating Factor and Total Antioxidant Capacity in Diagnosis of Acute Appendicitis

ccedil¹,

Okuş²,

Ay³

et al. 2016

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Background and Aim: Despite the fact that acute appendicitis is the most common surgical emergency all around the world, its diagnosis is still based on clinical evaluation and accuracy of the diagnosis depending on experience. The aim of this study is to evaluate the role of inflammatory markers in diagnosis of acute appendicitis. Material and Method: The study includes 77 cases with histopathologically proven acute appendicitis and 17 control cases. Blood samples were obtained from all cases and C-reactive protein (CRP), Granulocyte Colony Stimulating Factor (G-CSF) and Total Antioxidant Capacity (TAC) were measured. Findings: In cases with acute appendicitis, CRP and G-CSF levels were found to be related to acute appendicitis; however, TAC was not affected by the disease process. Moreover, CRP and G-CSF levels were correlated with the disease severity. Conclusion: Both CRP and G-CSF can be used in diagnosis of acute appendicitis. Furthermore, increased CRP level can be a marker to show advanced cases. However, G-CSF is not an effective marker to show disease severity.

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Section: Discussionmentioning

confidence: 95%

“…There is little data about the use of G-CSF in diagnosis of AA [9]. In a study, it is found to be useful in staging of AA [10].…”

Section: Introductionmentioning

confidence: 99%

The Role of C-Reactive Protein, Granulocyte Colony Stimulating Factor and Total Antioxidant Capacity in Diagnosis of Acute Appendicitis

ccedil¹,

Okuş²,

Ay³

et al. 2016

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show abstract

“…It may be raised in 50-90% of patients with acute appendicitis but again it is non-specific. Serum levels of inflammatory markers including CRP and WBC count cannot be reliably used to distinguish between acute appendicitis and other causes of abdominal pain (Dalal et al, 2005). They are more effective in supporting a clinical diagnosis of appendicitis than excluding the diagnosis (Birchley, 2006).…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Appendicitis in Children

Nwokoma¹

2012

Appendicitis - A Collection of Essays From Around the World

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“…Thus, a safe guess, which is done in preoperative way, ranges froma possible surgery to morbidity and mortality which are relevant to surgery. Different infl ammatory indicators (White blood cell (WBC), C-reactive protein (CRP) (4), D-lactate level (5), level of calprotectin (6), level of procaltinonin (7), many interleukins (8) and usage of monitoring methods in diagnosis of appendicitis are available in many studies related to discrimination of complicated/non complicated. Neutrophil and lymphocyte ratio (NLR) starts to fi nd place for itself recently between these indicators (9).…”

Section: Introductionmentioning

confidence: 99%

Laboratory in complicated appendicitis prediction and predictive value of monitoring

Aydın¹,

Soylu²,

Dandin³

et al. 2017

BLL

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OBJECTIVES: The purpose of the study was that monitoring, which is used in diagnosis of acute appendicitis, and laboratory values, were evaluated for verifying diagnosis of complicated appendicitis and these parameters revealed cut-off values in complicated acute/non-complicated appendicitis. METHODS: 195 patients, who had had an operation for acute appendicitis between January 2012 and March 2015 and who were proved to have acute complicated/non-complicated appendicitis from the results of histopathology consideration, were included in this study. Patients' age, preoperative serum, WBC, CRP, NLR and BT with USG results were evaluated. RESULTS: Among the groups, there were no meaningful differences in the sense of age. CONCLUSION: It is important that treatment options are evaluated to be able to discriminate complicated appendicitis fast and with a high accuracy. In the case that serum WBC is higher than 13800. CRP is higher than 5.98, NLR is higher than 4.87 and appendicitis diameter is longer than 11mm, infl ammation of appendicitis is complex with gangrene, perforation and abscess and it emphasizes the suggestion of surgical treatment option to patients (Tab. 4, Fig. 1, Ref. 28). Text in PDF www.elis.sk.

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Serum and Peritoneal Inflammatory Mediators in Children With Suspected Acute Appendicitis

Abstract: Hypothesis: Inflammatory markers differ between subjects with appendicitis and controls. Markers of inflammation differ in serum compared with intraperitoneal fluid. Among subjects with appendicitis, inflammatory markers differ between subjects with and without perforation.

Cited by 43 publications

References 21 publications

The Role of C-Reactive Protein, Granulocyte Colony Stimulating Factor and Total Antioxidant Capacity in Diagnosis of Acute Appendicitis

The Role of C-Reactive Protein, Granulocyte Colony Stimulating Factor and Total Antioxidant Capacity in Diagnosis of Acute Appendicitis

Appendicitis in Children

Laboratory in complicated appendicitis prediction and predictive value of monitoring

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