Serum Anti-müllerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict pregnancy rates in IVF/ICSI cycles

Şahmay, Sezai; Demirayak, Gökhan; Güralp, Onur; Öçal, Pelin; Şentürk, Levent M.; Oral, Engin; İrez, Tülay

doi:10.1007/s10815-012-9754-6

Cited by 20 publications

(12 citation statements)

References 35 publications

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“…In our previous studies we could not find AMH as a pregnancy prediction marker in both normoresponder and PCOS groups. However, we demostrated a parallel increase between the serum AMH levels and the pregnancy rates, but this correlation was insignificant [19,20].…”

Section: Commentsmentioning

confidence: 66%

Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

Şahmay¹,

Aydın

Atakul³

et al. 2013

Gynecological Endocrinology

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The relation of antimullerian hormone (AMH) levels with the clinical and biochemical markers of polycystic ovary syndrome (PCOS) could be different. A total of 463 PCOS patients were evaluated in this cross-sectional study. Groups were constructed according to polycystic ovarian morphology (PCOM) and menstrual cycle-length. The relation of serum AMH with androgenic hormones, menstrual cycle-length and clinical signs of PCOS were investigated. A powerful positive relation was found between the PCOM and AMH levels (odds ratio = 2.49). There was a negative correlation between age and AMH level (p < 0.001, r[correlation coefficent] = -0.155). Positive correlations were found between luteinizing hormone (LH) and AMH (p < 0.001, r = 0.25) and also between cycle length and AMH (p < 0.01, r = 0.27). We found a negative week correlation between AMH and follicle-stimulating hormone (FSH) (p = 0.01, r = -0.19). After controlling main androgenic hormones, AMH was found to be correlated with the Ferriman-Gallway score (p = 0.03, r = 0.18). There was a positive relationship between hirsutism and AMH (odds ratio = 1.43), but no correlation between AMH and other parameters of clinical hyperandrogenism like hair-loss, acne and seborrhea were identified. The strongest relation was presented between the AMH levels and PCOM. Also, cycle-length correlated well with the AMH levels. The relationship between hirsutism and AMH is found to be independent from androgenic hormones.

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Section: Commentsmentioning

confidence: 66%

Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

Şahmay¹,

Aydın

Atakul³

et al. 2013

Gynecological Endocrinology

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“…The clinical pregnancy rate was 21 % in patients that had serum AMH levels lower than 1.81 ng/ml (<25%percentile). The pregnancy rate increased slightly with the concomitant increase of serum AMH but the mean serum AMH values for the pregnant and nonpregnant groups were nonsignificant [18,19]. In these our published studies, there were no significant difference in AMH levels between pregnant and non-pregnant under aged 40 years women in both normoresponder and PCOS patient groups (3.9±2.5 vs 3.8±3.0 ng/ml, p=0.831; 6.79±2.9 vs 7.16± 4.29 ng/ml, p=0.594, respectively).…”

Section: Discussionmentioning

confidence: 81%

“…In our previous two studies on AMH and pregnancy prediction, we were unable to show AMH as being a good pregnancy prediction marker in both normoresponder and polycystic ovary syndrome (PCOS) groups [18,19].…”

Section: Introductionmentioning

confidence: 67%

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Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

Şahmay

Öncül

Tüten

et al. 2014

J Assist Reprod Genet

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Purpose To investigate whether serum anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), or antral follicle count (AFC) are predictive for clinical pregnancy in women who underwent IVF cycles at the age of 35 and older Methods A total of 240 consecutive women who underwent IVF cycles at the age of 35 and older were enrolled in this crsoss-sectional study. Pregnant and nonpregnant women were compared. Results The median AMH level of pregnant women was higher than non-pregnant women [3.20 (0.63-9.60) vs 1.15 (0.01-14.90) ng/ml, p<0.001]. On logistic regression analysis, AMH was an independent predictor of clinical pregnancy rate (CPR) (OR 1.353; 95 % CI 1.141-1.605; P<0.001). After controlling for the other independent variables (the number of retrieved oocytes, AFC and age), the significant association between AMH and clinical pregnancy rate remained strong (OR 1.677; 95 % CI 1.216-2.311; p=0.002) on multivariate logistic regression analysis. Conclusions AMH is an effective measure of quantitative ovarian reserve and it can predict ovarian response to controlled stimulation for advanced age women. The CPR tends to increase as AMH increases.

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“…In clinical practice, it is useful for the prediction of poor responders [8] and ovarian hyperstimulation syndrome (OHSS) [9]. Moreover, it is positively correlated with pregnancy rates [10,11].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

Şahmay

Aydın

Öncül

et al. 2013

J Assist Reprod Genet

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Purpose We assessed the utility of using anti-Müllerian hormone (AMH) and clinical features of polycystic ovary syndrome (PCOS), polycystic ovarian morphology (PCOM), oligo/amenorrhea (OA), and hyperandrogenism (HA) for diagnosing PCOS, and compared their diagnostic accuracy with those of classical diagnostic systems. Methods A total of 606 females were admitted to a university hospital with menstrual irregularities or symptoms of hyperandrogenism were enrolled in this cross-sectional study. Fasting blood samples were collected. Pelvic and/or abdominal ultrasonography and clinical examination were performed. Patients were evaluated for the presence of PCOS according to conventional diagnostic criteria. The diagnostic performance of using serum AMH levels alone and in various combinations with the clinical features of PCOM, OA, and HA were investigated. Results For the diagnosis of PCOS, the combination of OA and/or HA with AMH showed 83 % sensitivity and 100 % specificity according to the Rotterdam criteria; 83 % sensitivity and 89 % specificity according to the National Institutes of Health (NIH) criteria; and 82 % sensitivity and 93.5 % specificity according to the Androgen Excess Society (AES) criteria. Conclusions The serum AMH level is a useful diagnostic marker for PCOS and is correlated with conventional diagnostic criteria. The combination of AMH level with OA and/ or HA markedly increased the clinical scope for PCOS diagnosis and can be introduced as a possible objective criterion for the diagnosis of this disease.

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Serum Anti-müllerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict pregnancy rates in IVF/ICSI cycles

Abstract: Serum AMH and FSH, and AFC cannot predict clinical pregnancy in IVF patients under 40; the pregnancy rate tends to increase as AMH increases, although this remains non-significant.

Cited by 20 publications

References 35 publications

Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

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