Serum apolipoprotein A1 rather than apolipoprotein B is associated with hypertension prevalence in Chinese people with coronary artery disease

Dong, Hongli; Zhang, Yaju; Hu, Ping; Wang, Jie; Lu, Nan

doi:10.1097/mbp.0000000000000576

Cited by 7 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The serum lipid levels of the samples were evaluated by an Olympus AU5400 system (Olympus Corporation, Tokyo, Japan). TC, TG, LDL-C, HDL-C, apolipoprotein A1 (Apo-A1) and apolipoprotein B (Apo-B) analyses were carried out using the cholesterol esterase/peroxidase enzymatic method,12 glycerophosphate oxidase/peroxidase enzymatic method,13 direct surfactant removal method,14 direct immunoinhibition method15 and immunoturbidimetry method,16 respectively, according to the manufacturers’ instructions. Patients with a clear past history of hyperlipidaemia and/or a current serum lipid test that met criteria according to the 2016 Chinese Guidelines were diagnosed with dyslipidaemia 17…”

Section: Methodsmentioning

confidence: 99%

Characteristics of serum lipid levels in patients with hypertension: a hospital-based retrospective descriptive study

Huang

2022

BMJ Open

View full text Add to dashboard Cite

BackgroundDyslipidaemia is different among patients with hypertension in different populations. The serum lipid profiles among Hakka patients with hypertension in southern China are still unclear.Methods35 448 patients with hypertension were enrolled in this study from January 2016 to October 2020, and their serum lipids were analysed.ResultsLow high-density lipoprotein-cholesterol (HDL-C) (29.9%) accounted for the highest proportion in dyslipidaemia, followed by high triglyceride (TG) (20.7%), high total cholesterol (TC) (14.0%) and high low-density lipoprotein-cholesterol (LDL-C) (7.9%) in all subjects. The largest proportion of dyslipidaemia types was independent low HDL-C (12.7%). The proportion of low HDL-C was 15.5% in non-elderly men, 6.4% in non-elderly women, 16.7% in elderly men and 8.5% in elderly women, respectively. The largest proportion of dyslipidaemia types was independent high TG in non-elderly female patients (13.7%) and elderly patients (8.9%). The results showed that higher LDL-C, TC and TG levels in non-elderly patients than elderly patients. TG, TC and LDL-C levels decreasing with the increasing age, the differences were statistically significant. The levels of TG, TC, HDL-C and LDL-C in women were higher than in men among various age groups. Homocysteine level was increasing with increasing age.ConclusionsSerum lipid levels varied in different groups according to age and sex in patients with hypertension. Dyslipidaemia is more common in non-elderly patients than elderly. TG, TC and LDL-C levels were higher in female patients than male.

show abstract

Section: Methodsmentioning

confidence: 99%

Characteristics of serum lipid levels in patients with hypertension: a hospital-based retrospective descriptive study

Huang

2022

BMJ Open

View full text Add to dashboard Cite

show abstract

“…), 16,17) which have been confirmed to be associated with the occurrence of coronary artery disease (CAD). In addition, ApoA1 is negatively related to the prevalence of hypertension 18) and is generally regarded as an anti-atherosclerotic component. Our study showed that ApoA1 was negatively correlated with the RP of NCCLs.…”

Section: Discussionmentioning

confidence: 99%

The Value of the Apolipoprotein B/Apolipoprotein A1 Ratio in Predicting the Rapid Progression of Non-Culprit Coronary Lesions in Acute Coronary Syndrome in Patients with Diabetes Mellitus after Percutaneous Coronary Intervention

et al. 2023

View full text Add to dashboard Cite

This study aims to assess the predictive value of the apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio in acute coronary syndrome (ACS) in patients with diabetes mellitus (DM) for the rapid progression (RP) of non-culprit coronary lesions (NCCLs) after percutaneous coronary intervention (PCI) and observe the effect of the ApoB/ApoA1 ratio on major adverse cardiac events (MACE).A total of 175 patients with DM presenting with ACS who received a PCI and an average 13-month follow-up coronary angiography (CAG) were enrolled from January 2015 to December 2020. According to the CAG, the patients were divided into the RP group and the non-RP group. MACE was defined as a composite of death from cardiac causes, cardiac arrest, myocardial infarction, or rehospitalization from unstable or progressive angina at the end of a 24-month follow-up.The low-density lipoprotein cholesterol (LDL-C), ApoB, ApoB/ApoA1 ratio, and LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio levels at baseline were significantly higher in the RP group than in the non-RP group. The ApoA1 level at baseline in the non-RP group was significantly higher than in the RP group. The predictive significance of the ApoB/ApoA1 ratio (area under the curve (AUC) = 0.712) for the RP of NCCLs was significantly higher than those of ApoA1, ApoB, LDL-C/HDL-C ratio (AUC = 0.628, AUC = 0.640, and AUC = 0.620, respectively). A higher ApoB/ApoA1 ratio and the RP of NCCLs were significantly associated with the occurrence of MACE.The ApoB/ApoA1 ratio was an effective clinical indicator for the RP of NCCLs after PCI in patients with DM presenting with ACS. The high ApoB/ApoA1 ratio and the RP of NCCLs were two risks for MACE.

show abstract

“…Notably, OSA patients tend to have lower levels of HDL-C and ApoA1, markers commonly associated with high cardiovascular risk, 3,21,[33][34][35][36][37][38] but high levels of HDL-C and low levels of ApoA1 have been associated with an increased risk of T2DM. 39,40 Our MR analysis revealed a consistent trend amongst patients with OSA, in which they exhibited reduced levels of HDL-C and ApoA1.…”

Section: Discussionmentioning

confidence: 99%

How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study

Shen,

Wang,

Zhang

et al. 2023

NSS

View full text Add to dashboard Cite

Background Obstructive sleep apnea (OSA), high blood pressure (HBP), and type 2 diabetes mellitus (T2DM) have a close clinical relationship, but whether and how OSA affects HBP and T2DM is unclear. Study Design and Methods Two-step, two-sample Mendelian randomization techniques were applied using single-nucleotide polymorphisms as genetic instruments for exposure and mediators, thus minimizing bias due to confounding factors and reverse causality. The total effect of OSA on HBP and T2DM was categorized into direct and mediating effects based on the mediating factors. Results Two-sample MR analysis showed that OSA increased the risk of HBP (odds ratio [OR] = 1.010, 95% confidence interval [CI], 1.002–1.018; P = 0.0121) and T2DM (OR = 1.140, 95% CI, 1.059–1.228; P = 0.0005). In the process of OSA caused by HBP, sex hormone-binding globulin (SHBG) (female, 4.47% mediation; male, 2.76% mediation), total testosterone (TT) (male, 3.72% mediation), bioavailable testosterone (BioT) (female, 7.74% mediation), high-density lipoprotein cholesterol (HDL-C) (3.25% mediation), and apolipoprotein A1 (ApoA1) (1.31% mediation) were individual contributors. SHBG (female, 4.10% mediation; male, 1.58% mediation), TT (male, 3.69% mediation), BioT (female, 2.58% mediation), HDL-C (3.32% mediation), ApoA1 (2.14% mediation), and omega-6 fatty acids (2.33% mediation) may have mediating roles to varying degrees in the process of OSA caused by T2DM. Interpretation This MR study showed that OSA is a risk factor for HBP and T2DM, and the evaluation of mediators may help further reveal the specific mechanism by which OSA causes HBP and T2DM.

show abstract

Serum apolipoprotein A1 rather than apolipoprotein B is associated with hypertension prevalence in Chinese people with coronary artery disease

Abstract: Supplemental Digital Content is available in the text.

Cited by 7 publications

References 39 publications

Characteristics of serum lipid levels in patients with hypertension: a hospital-based retrospective descriptive study

Characteristics of serum lipid levels in patients with hypertension: a hospital-based retrospective descriptive study

The Value of the Apolipoprotein B/Apolipoprotein A1 Ratio in Predicting the Rapid Progression of Non-Culprit Coronary Lesions in Acute Coronary Syndrome in Patients with Diabetes Mellitus after Percutaneous Coronary Intervention

How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study

Contact Info

Product

Resources

About