Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension

Hu, Jinbo; Wang, Yue; Xiang, Xian-Ling; Peng, Chuan; Gao, Rufei; Goswami, Richa; Huang, Zhou; Zeng, Yi; Zhen, Qianna; Cheng, Qingfeng; Li, Qifu

doi:10.1097/hjh.0000000000000780

Cited by 39 publications

(34 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although renal excretion is another important aspect of uric acid metabolism, the urinary uric acid excretion seemed not to be influenced by BPA. We reported in earlier work that BPA is a predictor of 6 yr chronic kidney disease progression in patients with primary hypertension (11) and type 2 diabetes (22). Experimental studies also showed that BPA exposure promotes podocytopenia and proteinuria (39).…”

Section: Discussionmentioning

confidence: 98%

“…Apart from this, it should be noted that uric acid clearance does not decrease in proportion to the glomerular filtration rate in chronic kidney disease (40). Even though exposure of BPA decreases the glomerular filtration rate, the compensatory increase in uric acid excretion per nephron may help to maintain a normal level of uric acid clearance (11, 23, 39, 40).…”

Section: Discussionmentioning

confidence: 99%

“…Hyperuricemia was defined as a serum uric acid concentration greater than 420 mM in men and 360 mΜ in women. Serum concentrations of BPA were measured with a commercially available ELISA kit (IBL, Gunma, Japan) designed for the quantitative determination of BPA in human serum samples (11,23). The measurement range is 0.3-100 ng/ml.…”

Section: Matched Case-control Studymentioning

confidence: 99%

“…Bisphenol A (BPA), a widely used environmental chemical (9), has been associated with the incidence of hypertension, diabetes, and chronic kidney disease (10)(11)(12)(13). Experimental studies have shown the detrimental role of BPA in these metabolic disorders in vivo and in vitro (14,15).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Bisphenol A promotes hyperuricemia via activating xanthine oxidase

et al. 2018

FASEB j.

Self Cite

View full text Add to dashboard Cite

The prevalence of hyperuricemia has increased rapidly over the past decades. Bisphenol A (BPA) is an environmental endocrine disruptor. We investigated the effects of BPA on uric acid metabolism and its potential mechanisms. Experiments were performed in different animal models, cell cultures, and humans. In 3 different animal models, BPA exposure increased serum and hepatic uric acid with enhanced activity of xanthine oxidase (XO) in liver, whereas the excretion of uric acid was unchanged. Both in vivo and in vitro, BPA-induced uric acid production was decreased after treatment with allopurinol, which is a XO inhibitor. XO led to the accumulation of uric acid after xanthine was added, with the enzyme-catalyzed reaction, which was enhanced by BPA. Altered secondary structures of XO were found by circular dichroism analysis in the conditions of different BPA concentrations. Molecular docking portrayed Asp360 and Lys422 of XO to be the preferred binding sites for BPA. Mutation of both sites significantly blocked the effect of BPA on XO activity. In humans, patients with hyperuricemia exhibited higher levels of serum BPA than subjects without hyperuricemia. These findings demonstrate BPA promotes hyperuricemia by increasing hepatic uric acid synthesis via the activation of XO, probably through direct binding.-Ma, L., Hu, J., Li, J., Yang, Y., Zhang, L., Zou, L., Gao, R., Peng, C., Wang, Y., Luo, T., Xiang, X., Qing, H., Xiao, X., Wu, C., Wang, Z., He, J. C., Li, Q., Yang, S. Bisphenol A promotes hyperuricemia via activating xanthine oxidase.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Matched Case-control Studymentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Bisphenol A promotes hyperuricemia via activating xanthine oxidase

et al. 2018

FASEB j.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The likely mechanism involves the ability of BPA to disrupt normal estrogen-ER signaling in the vasculature, which normally affords vascular protection by promoting vascular injury repair and upregulation of vasodilators such as nitric oxide. Finally, it has recently been suggested that serum BPA levels could be used to predict the progression of chronic kidney disease in hypertensive individuals [200].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure

Hall

Greco

2019

Cells

View full text Add to dashboard Cite

Much of the early work on Nuclear Hormone Receptors (NHRs) focused on their essential roles as mediators of sex steroid hormone signaling in reproductive development and function, and thyroid hormone-dependent formation of the central nervous system. However, as NHRs display tissue-specific distributions and activities, it is not surprising that they are involved and vital in numerous aspects of human development and essential for homeostasis of all organ systems. Much attention has recently been focused on the role of NHRs in energy balance, metabolism, and lipid homeostasis. Dysregulation of NHR function has been implicated in numerous pathologies including cancers, metabolic obesity and syndrome, Type II diabetes mellitus, cardiovascular disease, hyperlipidemia, male and female infertility and other reproductive disorders. This review will discuss the dysregulation of NHR function by environmental endocrine disrupting chemicals (EDCs), and the associated pathological consequences of exposure in numerous tissues and organ systems, as revealed by experimental, clinical, and epidemiological studies.

show abstract

Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested case–control study

et al. 2018

View full text Add to dashboard Cite

Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension

Abstract: Serum BPA may be a predictor of CKD progression in patients with primary hypertension.

Cited by 39 publications

References 32 publications

Bisphenol A promotes hyperuricemia via activating xanthine oxidase

Bisphenol A promotes hyperuricemia via activating xanthine oxidase

Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure

Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested case–control study

Contact Info

Product

Resources

About