Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study

Hu, Jinbo; Peng, Chuan; Li, Jiayu; Gao, Rufei; Zhang, Aipin; Ma, Linqiang; Zhang, Linkun; Yang, Yi; Cheng, Qingfeng; Wang, Yue; Luo, Ting; Wang, Zhihong; Qing, Hua; Li, Qifu

doi:10.1016/j.semarthrit.2018.03.009

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…The criterion for a diagnosis of hyperuricemia is generally defined as SUA concentration >6.8 mg/dL. [25] A meta-analysis with a large sample size showed that hyperuricemia was positively associated with risk of stroke incidence and mortality. [26] This result was in agreement with our findings showing that people with a higher risk of stroke had higher levels of SUA compared with people with a low risk of stroke.…”

Section: Discussionmentioning

confidence: 99%

The risk of stroke and associated risk factors in a health examination population

Lei

et al. 2019

Medicine

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Section: Discussionmentioning

confidence: 99%

The risk of stroke and associated risk factors in a health examination population

Lei

et al. 2019

Medicine

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“…Bisphenols-induced oxidative stress in liver and renal endothelial cells can mediate hyperuricemia [ 1 , 10 , 50 ]. Nonetheless, only one adult study has been conducted for the effect of BPA exposure on hyperuricemia, reporting that baseline serum BPA levels predicted the development of hyperuricemia after 6 years of follow-up [ 52 ]. However, in this study, we did not find a significant association between BPA levels and uric acid levels.…”

Section: Discussionmentioning

confidence: 99%

Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children

et al. 2022

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Background Hyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease. Endocrine disruptors may affect uric acid metabolism; however, few epidemiologic studies have been performed in children regarding newly developed bisphenol A (BPA) substitutes. We evaluated the associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations in 6-year-old Korean children. Methods From the Environment and Development of Children cohort study, six-year-old children (N = 489; 251 boys) who underwent an examination during 2015–2017 were included. Anthropometry, questionnaires, and biological samples were evaluated. BPA, BPS, and BPF levels were measured from spot urine samples, and log-transformed or categorized into groups for analysis. We constructed linear regression models adjusting for age, sex, urinary creatinine levels, body mass index z-scores, and estimated glomerular filtration rates. Results Mean serum uric level was 4.2 mg dL-1 (0.8 SD) without sex-differences. Among the three bisphenols, higher BPS exposure was associated with increased serum uric acid concentrations (P-value for trend = 0.002). When BPS levels were categorized into three groups (non-detection < 0.02 μg L-1 vs. medium BPS; 0.02–0.05 μg L-1 vs. high BPS ≥ 0.05 μg L-1), the high BPS group showed higher serum uric acid concentrations (by 0.26 mg dL-1, P = 0.003) than the non-detection group after adjusting for covariates, which was significant in boys but not girls. Discussions Urinary BPS levels was positively associated with serum uric acid concentrations in 6-year-old children, and the association was more pronounced in boys. Considering the increasing use of BPS and concerning effect of hyperuricemia on health outcomes, their positive relationship should be investigated further.

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“…Two human studies were available addressing effects of BPA on General toxicity: Lee et al ( 2018c ) [RefID 12428] on liver toxicity and Hu et al ( 2019 ) [RefID 12151] 17 on kidney toxicity.…”

Section: Assessmentmentioning

confidence: 99%

“…Increased uric acid associated with BPA exposure was also observed in humans (Hu et al, 2019 [RefID 12151] 20 ).…”

Section: Assessmentmentioning

confidence: 99%

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

Lambré¹,

Baviera²,

Bolognesi³

et al. 2023

EFS2

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In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the risks to public health from the presence of BPA in foodstuffs and to establish a tolerable daily intake (TDI). For this re‐evaluation, a pre‐established protocol was used that had undergone public consultation. The CEP Panel concluded that it is Unlikely to Very Unlikely that BPA presents a genotoxic hazard through a direct mechanism. Taking into consideration the evidence from animal data and support from human observational studies, the immune system was identified as most sensitive to BPA exposure. An effect on Th17 cells in mice was identified as the critical effect; these cells are pivotal in cellular immune mechanisms and involved in the development of inflammatory conditions, including autoimmunity and lung inflammation. A reference point (RP) of 8.2 ng/kg bw per day, expressed as human equivalent dose, was identified for the critical effect. Uncertainty analysis assessed a probability of 57–73% that the lowest estimated Benchmark Dose (BMD) for other health effects was below the RP based on Th17 cells. In view of this, the CEP Panel judged that an additional uncertainty factor (UF) of 2 was needed for establishing the TDI. Applying an overall UF of 50 to the RP, a TDI of 0.2 ng BPA/kg bw per day was established. Comparison of this TDI with the dietary exposure estimates from the 2015 EFSA opinion showed that both the mean and the 95th percentile dietary exposures in all age groups exceeded the TDI by two to three orders of magnitude. Even considering the uncertainty in the exposure assessment, the exceedance being so large, the CEP Panel concluded that there is a health concern from dietary BPA exposure.

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Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study

Cited by 13 publications

References 27 publications

The risk of stroke and associated risk factors in a health examination population

The risk of stroke and associated risk factors in a health examination population

Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

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