Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice

Abstract

Cardiovascular disease is the most common cause of morbidity and mortality globally. Epidemiological studies using high-sensitivity assays for serum C-reactive protein have shown a consistent association between cardiovascular disease risk and serum C-reactive protein concentrations. C-reactive protein is a biomarker for inflammation, and has been established in clinical practice as an independent risk factor for cardiovascular disease events. There is evidence that serum C-reactive protein is an excellent biomarker of cardiovascular disease and is also an independent and strong predictor of adverse cardiovascular events. Further characterization of the impact and influence of lifestyle exposures and genetic variation on the C-reactive protein response to cardiovascular disease events may have implications for the therapeutic approaches to reduce cardiovascular disease events. This review summarizes the studies that have examined the association between serum C-reactive protein and the risk of cardiovascular disease. We also discuss the impact of independent factors and C-reactive protein genetic polymorphisms on baseline plasma C-reactive protein levels.

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitness in US Adults

“…High circulating acute phase inflammatory markers, i.e., C-reactive protein and fibrinogen have been linked to chronic inflammatory diseases such as MetS, diabetes, obesity, and CVD [50][51][52]. [53] suggesting that vitamin D is an anti-inflammatory agent [54].…”

Relationship between serum high sensitivity C‐reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors

“…hs-CRP: high sensitivity C-reactive protein; PPV: positive predictive value; NPV: negative predictive value. | 10295 that high-density fatty acids and cholesterol increase the risk of CAD through the raise of serum total cholesterol and LDL (Avan et al, 2018;Bray et al, 2017;Peyman & Oakley, 2011). The mean dietary fiber intake in the control group was significantly higher than the case group.…”

Сравнительная характеристика сорбентов для удаления иммуноглобулинов (сравнение in vitro)

“…По данным эпидемиологических исследований, была показана связь CРБ с заболеваниями аутоиммунной природы, такими как воспалительное заболевание кишечника [34], РА [35], сердечно-сосудистые заболевания [36], СД 2-го типа [37], и общей смертностью [36]. Американское общество сердца (American Heart Association, AHA), Канадское сердечно-сосудистое общество (Canadian Cardiovascular Society, CCS) и Национальная академия клинической биохимической лабораторной медицины США (National Academy of Clinical Biochemistry Laboratory Medicine Practice, NACB) предполагают, что СРБ может играть ключевую роль во многих проявлениях сердечно-сосудистых заболеваний, несмотря на то что пока не получено прямых доказательств его участия в патогенезе заболевания [38,39]. Достоверное уменьшение зоны некроза в экспериментальной модели инфаркта миокарда после удаления СРБ из крови животных в процедурах экстракорпорального кровообращения, описанного в работе А.…”