Serum C-reactive protein is an independent risk factor predicting cardiometabolic risk

Determinants of C-reactive protein concentrations in pregnant women with type 1 diabetes

“…4,28 To date, there have been no studies linking CRP levels with IR and lipids in pregnancy; nonetheless, both elevated IR and dyslipidemia have been linked to chronic low-grade inflammation in adipose tissue. 4, [29][30][31] In this study, CRP levels were correlated with total cholesterol, LDL cholesterol, and TG levels. To test whether these associations were secondary to adiposity, we performed the multiple regression analysis and found that the association remained significant for total cholesterol and LDL cholesterol, but was no longer observed for TGs after adjustment for WHR.…”

High sensitivity C-reactive protein is associated with the metabolic syndrome independent to viral and bacterial pathogen burden

“…Multiple cross-sectional and prospective epidemiological studies showed an association between hs-CRP and the metabolic syndrome and its components [11][12][13][14][15][16][17][18][19][20]. However, the mechanisms responsible for the low-grade up-regulation of CRP production that predicts development of the metabolic abnormalities in general population are not clearly understood.…”

“…Several studies have reported a relationship between components of the metabolic syndrome, according to the ATP III definition, and hs-CRP [16,17,20,35,36].…”

“…Some prospective epidemiological evidence linking inflammation with the metabolic syndrome has been accumulated [18][19][20].…”

The Answer to Why Some Are Obese but Healthy?!

“…WAT has a role in the regulation of whole-body energy metabolism and its endocrine function has a critical role in the development of obesity and its metabolic and cardiovascular complications by secreting cytokines/adipokines in distorted proportions. In obese individuals, monocyte and B and T lymphocyte infiltration into the adipose tissue results in low-grade inflammatory state associated with a rise in circulating C-reactive protein (CRP) which could be used as a marker for the development of type 2 diabetes mellitus (T2DM) and insulin resistance (IR) [2][3][4]. However, it should be noted that obesity itself will not lead to the development of IR but, the adipose tissue inflammatory condition is the culprit in metabolic disorders of humans [2].…”