Serum C reactive protein level in type 2 diabetes  mellitus patients attending diabetic clinic  in Benin City, Nigeria

Ehiaghe, Alfred Friday; Agbonlahor, D. E.; Tatfeng, Youtchou Mirabeau; Folarin, Onikepe A.; Oviasogie, F.E.; Ehiaghe, Joy Imuetinya

doi:10.4236/jdm.2013.34026

Cited by 5 publications

(7 citation statements)

References 14 publications

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“…The level of CRP was significantly higher in female patients when compared to males ( Table 5). Similar to other studies an elevation of serum C-reactive protein was demonstrated in both Males and Females type 2 Diabetes mellitus 27 . CRP was not a significant predictor of the development of the metabolic syndrome in men.…”

Section: Fig 2: Gender Distributionsupporting

confidence: 76%

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2017

IJPSR

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Section: Fig 2: Gender Distributionsupporting

confidence: 76%

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2017

IJPSR

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“…They consist of 40 known type 2 diabetes mellitus and 40 aged matched apparently healthy control subjects on routine checkup. They were confirmed to be diabetics and non diabetics respectively using the glucose oxidase method as previously described by Ehiaghe et al (2013).…”

Section: Materials and Methods Subjectsmentioning

confidence: 99%

“…Glucose oxidase method was used in the determination of blood glucose as previously described by Ehiaghe et al (2013). In brief, 10 µl of the standard or test samples was added to 1000 µl of glucose reagent 1, mixed and incubated for 25 minutes at 20 0 C.The absorbance of the standard and test samples was measured against the reagent blank within 60 minutes at a wavelength of 540 nm using a spectrophotometer.…”

Section: Determination Of Blood Glucose Levelmentioning

confidence: 99%

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Some physiochemical changes associated with type 2 diabetes mellitus in Benin City, Nigeria

Ehiaghe¹

2016

Int. J. Bio. Chem. Sci

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The present study was designed to determine the level of malondialdehyde (MDA) concentration, serum c reactive protein (CRP) and CD4 + T cells in type 2 diabetes mellitus in a view to assessing the complications associated with the non specific activation of CD4 + T cells. A total of 80 subjects aged between 18 and 50 years gave their consent to participate in the study. They consist of 40 known type 2 diabetes mellitus and 40 aged matched apparently healthy control subjects on routine checkup. Malondialdehyde concentration was determined by spectrophotometric method. Serum c reactive protein was determined by enzyme-linked immunosorbent assay method. CD4 + T cells were estimated using Partec cyflow counter. There was a significant increase in MDA concentration, CRP and CD4 + T cells in type 2 diabetes mellitus subjects when compared with the aged matched control group (P < 0.05). Type 2 diabetes mellitus causes an increased production of free radicals which is possibly linked to the complications associated with non specific activation of CD4 + T cells.

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“…C-reactive protein is an inflammatory marker originally found in sera of those that reacted with cpolysaccharide within cellular wall of Streptococcus pnuemonia produced and released by the liver under the stimulation of pro inflammatory cytokines such as interleukin 1 and 6, tumor necrosis factor [9,10]. Alpha 1 -antitrypsin is a protease inhibitor which protects tissue from enzyme inflammatory cells especially neutrophil elastase, but the concentration rises many fold upon acute inflammation, pregnancy, oral contraceptive [11].…”

Section: Introductionmentioning

confidence: 99%

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

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U²,

C³

2019

SJBR

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Type 2 diabetes mellitus is a chronic metabolic disorder which has emerged as a health challenge globally due to its insidious on set, late recognition and complications. The present study was aimed at evaluation of acute phase inflammatory proteins in Owerri. Cross Sectional Studies was conducted at Federal Medical Center and Imo State specialist Hospital, Owerri. A total of three hundred subjects which include each one hundred and fifty type 2 diabetics and apparently control subjects between the ages forty and sixty nine years were recruited. Ten millimeters of venous blood was aseptically collected from the subjects. Spectrophotometric, nephlometric, enzyme immunoassay were used for determination of these parameters. The data was analyzed using statistical package for social science 20.0. Test with a probability value of P<0.05 was considered statistically significant. Result from acute phase inflammatory proteins showed that the mean value of c-reactive protein alpha 1-acid glycoprotein, alpha1-antitrypsin, haptoglobin and ceruloplasmin in type 2 diabetics (5.21± 0.91mg/l, 99.34±17.84mg/dl, 152.32 ± 26.69, 154.03±7.75mg/dl, 47.83 ± 6.20mg/dl) were higher which was statistically significant (P=0.001) when compared with the control subjects (3.14± 0.80mg/l,76.86 ± 12.41mg/dl, 114.94±16.11mg/dl, 132.80 ± 79mg/dl, 34.47 ± 3.75mg/dl). There was statistically significant progressive decrease (P=0.04) in c-reactive protein (5.50 ± 0.98, 5.08 ± 0.84, 5.0 4± 0.83mg/l );significant increase (P =0.001) in haptoglobin (149.40 ± 7.78, 155.96 ± 7.93, 157.84 ± 6.12mg/dl) and ceruloplasmin (45.54 ± 6.84, 46.92 ± 5.79, 51.44 ± 6.12mg/dl).The mean value alpha1-acid glycoprotein in female type 2 diabetics was statistically significantly higher (P=0.001) when compared to male (10.912± 17.29 v 89.55± 0.19mg/dl) .

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Serum C reactive protein level in type 2 diabetes mellitus patients attending diabetic clinic in Benin City, Nigeria

Cited by 5 publications

References 14 publications

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Some physiochemical changes associated with type 2 diabetes mellitus in Benin City, Nigeria

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

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