Serum CA 125 and first trimester abortion

Scarpellini, F.; Mastrone, M; Sbracia, Marco; Scarpellini, L

doi:10.1016/0020-7292(95)02371-i

Cited by 19 publications

(11 citation statements)

References 16 publications

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“…The sensitivity and specificity attained using a single cutoff level of serum progesterone level above 45 nmol/l was 88%, which may represent improvement over other single tests; however, it does not remove the need for ultrasound or other follow up tests. Another study has looked at the prognostic value for fetal outcome when CA125 and beta hCG levels are used together 18 . At present, however, the role of hormone measurement in the clinical management of early pregnancy failure and prognosis of fetal viability is extremely limited.…”

Section: Discussionmentioning

confidence: 99%

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

Qureshi

Edi-Osagie

Ogbo³

et al. 2005

BJOG

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Objective To determine whether administration of exogenous human chorionic gonadotrophin (hCG) treatment improve the pregnancy outcome in first trimester threatened miscarriages. Design A prospective, double blind, randomised, placebo-controlled trial.Setting The Early Pregnancy Assessment Unit, Royal Bolton Hospital, Bolton, United Kingdom.Population One hundred and eighty-three women with vaginal bleeding and a viable fetus seen on ultrasound scan (USS) in the first 12 weeks of pregnancy. Methods The patients were randomised to receive either hCG or placebo treatment until 14 weeks of gestation.Main outcome measures The primary objective of the trial was to determine the miscarriage rate in the hCG arm compared from the placebo arm. Results Of the 183 cases, 87 were randomised to treatment with hCG while 96 were randomised to receive a placebo. Forty-seven (25%) did not comply with the study protocol. 5] in the study. The number of patients actively bleeding per vaginum at presentation was 85 (93%) in placebo group and 79 (96%) in the hCG group. The median number of hCG or placebo injections for both groups was 7. Ten women (11%) in the placebo group proceeded to have a complete miscarriage, as did 10 women (12%) in the hCG group, relative risk (RR) [95% confidence interval (CI)] of 1.1 (0.63 -1.6). Conclusion Our study showed no evidence of a difference in the outcome of threatened miscarriages when treated with hCG in the first trimester, this may be because our study sample size was small and follow up was suboptimal. A large, randomised, multicentre trial is still needed to establish the usefulness of hCG treatment in cases of threatened miscarriage.

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Section: Discussionmentioning

confidence: 99%

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

Qureshi

Edi-Osagie

Ogbo³

et al. 2005

BJOG

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“…However, it is a subjective ® nding especially during early pregnancy and, in our experience, unreliable. Scarpellini et al (1995) em phasised the high serum levels of CA125 in patients with threatened abortion. There is similar interest in the evaluation of serum CA125 in current research studies.…”

Section: Discussionmentioning

confidence: 98%

“…Integrity of the gestational sac can be detected at 33± 35 days while the cardiac activity can be demonstrated as early as 40 days from last period using transvaginal scanning. Serum CA125, which is a monoclonal antibody ® rst developed by Bast and his colleagues (1983) against epithelial ovarian cancers, was reported by Scarpellini et al (1995) to be at higher levels in the sera of women with threatened abortion especially when associated with negative outcomes. They suggested that the value o f C A 125 c ould b e a progn ostic factor for the pregnancy outcome in patients with threatened abortion.…”

Section: Introductionmentioning

confidence: 99%

Can a single serum CA125 assay predict the outcome of threatened abortion?

Ag²,

Shalan³

et al. 2000

Journal of Obstetrics and Gynaecology

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Earlier work suggested that high levels of CA125 could be detected in the sera of women with threatened abortion. In this study, we used CA125 as a method of anticipating outcome in cases of threatened abortion and compared the results with ultrasonic findings. Three groups of patients were studied.(1) 57 women who threatened to abort, but whose pregnancy continued.(2) 43 women with a threatened abortion, who subsequently aborted, and (3) 50 normal women who had no bleeding in early pregnancy. There was a highly significant increase in serum CA125 in women who aborted compared with the other two groups (P<0.001). The results compared well with conventional ultrasound and serum CA125 may be developed as a cheap, sensitive and specific predictor of outcome in cases of threatened abortion.

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“…This high level is likely due to tropho-decidual origin of this marker and invasion of deciduas by chorionic villi. This decidual disruption is associated with vaginal bleeding (16)(17).…”

Section: Discussionmentioning

confidence: 99%

Dermatlas:An Online Collaborative Education Tool

2002

IJD

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Serum CA 125 and first trimester abortion

Abstract: Our findings are in accordance with the hypothesis of a tropho-decidual origin of this marker, suggesting its possible usefulness in the prognostic evaluation of first trimester threatened abortion.

Cited by 19 publications

References 16 publications

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

Can a single serum CA125 assay predict the outcome of threatened abortion?

Dermatlas:An Online Collaborative Education Tool

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