Serum Carbohydrate Deficient Transferrin as A Sensitive Marker in Diagnosing Alcohol Abuse: A Case – Control Study

Madhubala, V; Subhashree, A R; Shanthi, B.

doi:10.7860/jcdr/2013/5137.2726

Cited by 16 publications

(9 citation statements)

References 17 publications

(15 reference statements)

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“…Other common hematologic findings include anemia, macrocytosis, leucopenia, lymphocytopenia, and thrombocytopenia (Bell et al, 1994;Mundle et al, 2000;Mathurin et al, 2002;Nguyen-Khac et al, 2011). Recently described biomarkers for chronic alcohol use can aid the diagnosis of AH (Anton and Moak, 1994;Berlakovich et al, 2004;Hock et al, 2005;Hietala et al, 2006;Niemela, 2007;Madhubala et al, 2013).…”

Section: Laboratory Findingsmentioning

confidence: 99%

Alcoholic Hepatitis: A Review

Hosseini

Shor

Szabó

2019

Alcohol and Alcoholism

132

117

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Alcoholic liver disease (ALD) represents a spectrum of injury, ranging from simple steatosis to alcoholic hepatitis to cirrhosis. Regular alcohol use results in fatty changes in the liver which can develop into inflammation, fibrosis and ultimately cirrhosis with continued, excessive drinking. Alcoholic hepatitis (AH) is an acute hepatic inflammation associated with significant morbidity and mortality that can occur in patients with steatosis or underlying cirrhosis. The pathogenesis of ALD is multifactorial and in addition to genetic factors, alcohol-induced hepatocyte damage, reactive oxygen species, gut-derived microbial components result in steatosis and inflammatory cell (macrophage and neutrophil leukocyte) recruitment and activation in the liver. Continued alcohol and pro-inflammatory cytokines induce stellate cell activation and result in progressive fibrosis. Other than cessation of alcohol use, medical therapy of AH is limited to prednisolone in a subset of patients. Given the high mortality of AH and the progressive nature of ALD, there is a major need for new therapeutic intervention for this underserved patient population.

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Section: Laboratory Findingsmentioning

confidence: 99%

Alcoholic Hepatitis: A Review

Hosseini

Shor

Szabó

2019

Alcohol and Alcoholism

132

117

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“…Furthermore, there were no significant differences between subjects or between groups over time in small samples of healthy male social drinker volunteers receiving 20, 40, 60 or 80 g alcohol/day over a 21 day period, suggesting that CDT is not a good marker for short-term alcohol consumption, even at 80 g/day [ 203 ]. Results of recent studies correlating CDT with alcohol consumption patterns are shown in Table 4 [ 77 , 90 , 93 , 102 , 105 , 147 , 157 , 158 , 166 , 191 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 ].…”

Section: Carbohydrate-deficient Transferrinmentioning

confidence: 99%

Biomolecules and Biomarkers Used in Diagnosis of Alcohol Drinking and in Monitoring Therapeutic Interventions

Nanau

Neuman

2015

Biomolecules

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Background: The quantitative, measurable detection of drinking is important for the successful treatment of alcohol misuse in transplantation of patients with alcohol disorders, people living with human immunodeficiency virus that need to adhere to medication, and special occupational hazard offenders, many of whom continually deny drinking. Their initial misconduct usually leads to medical problems associated with drinking, impulsive social behavior, and drunk driving. The accurate identification of alcohol consumption via biochemical tests contributes significantly to the monitoring of drinking behavior. Methods: A systematic review of the current methods used to measure biomarkers of alcohol consumption was conducted using PubMed and Google Scholar databases (2010–2015). The names of the tests have been identified. The methods and publications that correlate between the social instruments and the biochemical tests were further investigated. There is a clear need for assays standardization to ensure the use of these biochemical tests as routine biomarkers. Findings: Alcohol ingestion can be measured using a breath test. Because alcohol is rapidly eliminated from the circulation, the time for detection by this analysis is in the range of hours. Alcohol consumption can alternatively be detected by direct measurement of ethanol concentration in blood or urine. Several markers have been proposed to extend the interval and sensitivities of detection, including ethyl glucuronide and ethyl sulfate in urine, phosphatidylethanol in blood, and ethyl glucuronide and fatty acid ethyl esters in hair, among others. Moreover, there is a need to correlate the indirect biomarker carbohydrate deficient transferrin, which reflects longer lasting consumption of higher amounts of alcohol, with serum γ-glutamyl transpeptidase, another long term indirect biomarker that is routinely used and standardized in laboratory medicine.

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“…Raman spectra of Zinc sulphate doped LTDP crystal recorded at room temperature using a Nicolet 5700 spectrometer with NXP FT-Raman module was used ( number of scans ; 256, laser power at sample: 0.44w, resolution: 4 cm -1 spectral range : 4000-150 cm -1 ). The wave number ranges from 0 to 3500 cm -1 and assignment for the modes is made on the basis of Raman vibrations in some similar complex molecules [7,8] . The peak at 2047 cm -1 shows N=C= S stretching vibrations.…”

Section: Ft-ir Raman Studymentioning

confidence: 99%